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This chapter challenges the widely held belief that more consumer choices lead to better outcomes. This chapter explores how the proliferation of options, while seemingly empowering, can actually lead to decision paralysis, dissatisfaction and unsustainable consumption patterns. The myth is rooted in classical economic theories that equate more choice with freedom and personal satisfaction, but ps
High-risk neuroblastoma is characterized by MYCN amplification and high MYCN or MYC gene expression. These patients have a poor prognosis and there is an urgent need for more effective drugs. While strategies to develop inhibitors that directly target the MYC proteins have remained largely unsuccessful, recent preclinical studies have identified ATR, a key protein of the DNA damage response, as a
This chapter challenges the widespread belief that shopping provides lasting happiness and stress relief. This myth, often referred to as ‘retail therapy’, suggests that consumption serves as an effective coping mechanism for emotional distress. Rooted in post-war consumer culture and reinforced by advertising, this idea has normalised the use of material goods to manage emotions, fostering a depe
In this paper we review the physics opportunities at linear e+e− colliders with a special focus on high centre-of-mass energies and beam polarisation, take a fresh look at the various accelerator technologies available or under development and, for the first time, discuss how a facility first equipped with a technology that is mature today could be upgraded with technologies of tomorrow to reach m
BACKGROUND: HYPO-RT-PC is a phase 3 trial comparing ultra-hypofractionated and conventionally fractionated radiotherapy in intermediate-to-high-risk localised prostate cancer. This 10-year update reports long-term efficacy and toxicity outcomes.METHODS: In this open-label, randomised, phase 3, non-inferiority trial done in ten centres in Sweden and two in Denmark, we recruited men aged 75 years or
We present the characterisation of the TOI-6041 system, a bright (V = 9.84 ± 0.03) G7-type star hosting at least two planets. The inner planet, TOI-6041 b, is a warm Neptune with a radius of 4.55-0.17+0.18 R⊕, initially identified as a single-transit event in TESS photometry. Subsequent observations with TESS and CHEOPS revealed additional transits, enabling the determination of its 26.04945-0.000
Background: Globally, undernutrition is responsible for over 3.5 million deaths among children under the age of 5. In Mozambique, it remains a major contributing factor to the high rates of child mortality and illness. Essential micronutrients like zinc, iron, and calcium play a vital role in healthy growth and development. However, their absorption is hindered by anti-nutrients such as phytates,
Studies of the surface chemistry of the first few cycles of atomic layer deposition (ALD) using in situ and time-resolved operando techniques are attractive for realizing, understanding, and obtaining true mechanistic information during the deposition. However, the latter techniques are yet to be applied to ALD of metal nitrides. Here, we present a surface-chemistry investigation through a time-re
Summary: In this meta-analysis of international cohorts, current smoking is confirmed as a significant BMD-independent predictor of future fracture with a stronger relationship in men than in women. A causative and reversible effect of smoking on fracture risk is suggested by past smoking having a significantly lower risk than current smoking. Purpose: In this meta-analysis of international cohort
Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging shows myocardial fibrosis and is associated with outcome in repaired Tetralogy of Fallot (rToF). However, patients with rToF have surgical material implanted, also appearing bright in LGE images. Therefore, right ventricular myocardial fibrosis could be overestimated or falsely diagnosed, which may affect prognostic va
Heat pumps are a key technology for decarbonizing residential heating, yet their diffusion remains limited in many countries, partly due to challenges of public acceptance and legitimacy. This study tracks how heat pumps are portrayed in German public discourse by analyzing sentiment in online news coverage. We compile a corpus of 33,131 German heat pump–related news articles published between 201
Several factors contribute to the use, non-use, or inadequate use of personal protective equipment (PPE) in construction work. This study aimed to analyse correct usage of various PPE, such as helmet, ear protectors, goggles, respiratory mask, gloves, protective clothing, and a safety harness. Correct usage was assessed as guessability, which refers to human perceptions of how to don, adjust, use,
BACKGROUND: Rapeseed is the second most cultivated oilseed globally after soybean and a protein-rich press cake is generated after liberation of the oil. However, its use in food applications is limited by high levels of anti-nutrients such as glucosinolates and phytic acid. Although differences between botanical varieties are known, controlled comparisons of modern spring varieties for protein fu
Background: Repetitive and monotonous work is often associated with neck pain, potentially resulting in sick leave and reduced productivity. Establishing appropriate muscle activity patterns, including duration and frequency of breaks that can prevent neck pain development, is important for providing workplace guidance. While several smaller studies addressing monotonous neck-loading work have ind
α-Synuclein (αSyn) is a neuronal protein predominantly found at the synapse, involved in vesicle trafficking. αSynaggregates are also the main component of Lewy bodies, the hallmarks of Parkinson’s disease. Interactions between the N- and Cterminiof αSyn play crucial roles in its behavior in solution, membrane binding, and aggregation. Studying these interactionsprovides valuable insights into theα-Synuclein (αSyn) is a neuronal protein predominantly found at the synapse, involved in vesicle trafficking. αSyn aggregates are also the main component of Lewy bodies, the hallmarks of Parkinson’s disease. Interactions between the N- and C-termini of αSyn play crucial roles in its behavior in solution, membrane binding, and aggregation. Studying these interactions provides valuable insights
The first results of K*(892) ± production at midrapidity (| y | ' 0.5) in pp collisions at s=13 TeV as a function of the event multiplicity are presented. The K*(892) ± has been reconstructed via its hadronic decay channel K*(892)±→π±+KS0 using the ALICE detector at the LHC. For each multiplicity class, the differential transverse momentum (p T) spectrum, the mean transverse momentum ⟨ p T⟩, the
