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microRNA (miRNA) are small non-coding RNA, 21-23 nucleotides long. miRNA provide a new layer of regulatory control over gene expression programs. It is increasingly evident that miRNA are cell type and tissue specific. Many miRNAs have been identified to be highly abundant in certain regions of the brain. It has also been shown that alterations in levels of specific miRNAs have implications in var
MicroRNAs (miRNA) are small, non-coding RNAs mediating post-transcriptional regulation of gene expression. miRNAs have recently been implicated in hippocampus-dependent functions such as learning and memory, although the roles of individual miRNAs in these processes remain largely unknown. Here, we achieved stable inhibition using AAV-delivered miRNA sponges of individual, highly expressed and bra
Objective. To evaluate the association between the number of teeth and cognitive functions adjusted for age and education level in a cohort of older adults living in Sweden. Materials and methods. The study employed a cross-sectional design in which 1147 individuals between 60-96 years underwent a clinical oral examination. The cognitive functions were assessed using Mini-Mental State Examination
Soil extracts are routinely used to quantify dissolved organic nutrient concentrations in soil. Here we studied the loss and transformation of low molecular weight (LMW) components of DOC (C-14-glucose, 1 and 100 mu M) and DON (C-14-amino acid mixture, 1 and 100 mu M) during extraction of soil (0-6 h) with either distilled water or 0.5 M K2SO4. The extractions were performed at 20 degrees C, at 4
During the past few years, mobile phones and other handheld devices have gone from only handling dull text-based menu systems to, on an increasing number of models, being able to render high-quality three-dimensional graphics at high frame rates. This paper is a survey of the special considerations that must be taken when designing graphics processing units (GPUs) on such devices. Starting off by
For most neurodegenerative diseases the precise duration of an individual cell's death is unknown, which is an obstacle when counteractive measures are being considered. To address this, we used the rd1 mouse model for retinal neurodegeneration, characterized by phosphodiesterase-6 (PDE6) dysfunction and photoreceptor death triggered by high cyclic guanosinemono-phosphate (cGMP) levels. Using cell
The new generation of extremely large telescopes will have adaptive optics. Due to the complexity and cost of such systems, it is important to simulate their performance before construction. Most systems planned will have Shack-Hartmann wavefront sensors. Different mathematical models are available for simulation of such wavefront sensors. The choice of wavefront sensor model strongly influences c
When the Swedish construction code (in 1994) allowed wooden multi-storey buildings to be built, this type of lightweight construction became popular due to its low cost and ease of construction, and also because wood is a plentiful resource in Sweden. Drawbacks in such buildings are disturbing vibrations and noise propagating in the construction, especially through junctions. In lightweight constr
Background: During wound healing processes fibroblasts account for wound closure by adopting a contractile phenotype. One disease manifestation of COPD is emphysema which is characterized by destruction of alveolar walls and our hypothesis is that fibroblasts in the COPD lungs differentiate into a more contractile phenotype as a response to the deteriorating environment. Methods: Bronchial (centra
Drawing on Security, Territory, Population and The Birth of Biopolitics, this article aims, firstly, to consolidate our understanding of Foucault’s engagement with law by fleshing out his approach to law and by clarifying that he distinguishes between different kinds of law on the basis of the objectives that law serves and the regime of truth that it embodies. Secondly, using this understanding,
Background: Over time, methods for the development of clinical decision support (CDS) systems have evolved from interpretable and easy-to-use scoring systems to very complex and non-interpretable mathematical models. In order to accomplish effective decision support, CDS systems should provide information on how the model arrives at a certain decision. To address the issue of incompatibility betwe
We present a framework based on object orientation with novel principles for how to store, analyze and integrate electrophysiological data. These principles are: (I) Using a Decorator pattern for storing analysis data in an object model, (II) using a Core Classes data structure for integration through mediation in a service bus architecture, and (III) choosing the single unit as the finest structu
In the first part of this thesis discrete time hedging is considered. In paper A an adaptive hedging scheme where the hedge portfolio is re-balanced when the hedge ratios differ by some amount, here denoted eta, is investigated. An expression of the normalized expected mean squared hedging error as eta tends to zero is derived. The result is compared to an earlier result on discrete time hedging o
Zinc phthalocyanine (ZnPc) adsorbed on the InSb(0 0 1)-c(8 x 2) surface has been studied by scanning tunneling microscopy (STM) and X-ray photoelectron spectroscopy (XPS). Coverages from sub-monolayer to monolayer (ML) have been investigated. The molecules form ordered structures on the reconstructed rows of the surface with the molecular plane parallel to the surface. A change in the electronic s
Homogeneous alcoholic isotropic solutions (L-2 phases) of "complex salts'' of hexadecyltrimethylammonium neutralized by polyacrylate CTAPA(n) (n = 30 or 6000), in the presence of water were examined at 25 degrees C by means of small-angle X-ray scattering (SAXS), rheology and NMR self-diffusion measurements for different n-alcohols (octanol, hexanol and butanol) and at varying water contents. The
