Universal screening for defective mismatch repair (dMMR) in colorectal cancer utilizes immunohistochemical staining for MLH1, MSH2, MSH6 and PSM2. Additionally, BRAF V600E mutations status and MLH1 hypermethylation should be performed to distinguish germline and somatic dMMR alterations. A decade of Danish population-based registries has been analysed regarding screening uptake, detection rate and

Objectives The purpose of a parallel-hole collimator in a scintillation camera system is to transmit only those photons that have an emission angle close to the direction of the hole. This makes it possible to receive spatial information about the origin of the emission, that is, radioactivity decay. The dimension, shape, and intrahole thickness determine the spatial resolution and, by a tradeoff,

Objectives Collimators have a significant role in image quality and detectability in single-photon emission computed tomography (SPECT) imaging. Using an appropriate alloy that effectively absorbs scattered photons, without induced secondary x-rays, and with proper rigidity and weight may provide an effective approach to the image improvement that conventionally collimators made of lead (Pb). Mate

De senaste åren har den digitaliserade gigekonomin och de nya arbetsformerna plattformsarbete och egenanställd etablerats i Sverige och övriga EU-länder. Gemensamt är att själva arbetet fragmentiserats och består av korta uppdrag åt ett flertal uppdragsgivare som förmedlas via en digital delningsplattform eller app. Den som utför en arbetsprestation gör det antingen som anställd eller som företaga

The external ventricular drain (EVD) is an important instrument in the management of neuro-intensive care patients through its ability to meassure intracranial pressure and to treat increased intracranial pressure by drainage of cerebrospinal fluid (CSF). However, EVDs are associated with the risk of external ventricular drain related infection (EVDRI). EVDRI diagnosis is challenging as symtoms an

Under åren 1941–1943 steg dödstalen brant på Vipeholms sjukhus, ettstatligt sinnessjukhus för vård av så kallade ”svårskötta obildbara sinnesslöa”. Dehöga dödstalen har, framför allt i massmedia, tolkats som att Hugo Fröderberg,överläkare på Vipeholm, utsatte patienterna för medveten dödssvält eller eutanasi.Stöd för denna tolkning utgörs bland annat av de avlidna patienternas lågakroppsvikt samt

This chapter deals with the Swedish regulation of prenatal diagnosis and the various arguments posed for or against such regulation, including whether there should be any changes in the legislation of late-term abortions. Using the metaphor ‘moral landscape,’ it explores how actors such as physicians, disability organizations, and women’s organizations negotiated their position on an issue that waThis chapter deals with the Swedish regulation of prenatal diagnosis and the various arguments posed for or against such regulation, including whether there should be any changes in the legislation of late-term abortions. Using the metaphor ‘moral landscape,’ it explores how actors such as physicians, disability organizations, and women’s organizations negotiated their position on an issue that wa

There is an ever-increasing demand for structural metals with higher strength. Metals can be strengthened by reducing grain size in their microstructure, but ductility is also concomitantly reduced. High strength and ductility are a desirable combination of properties for most structural engineering materials. By arranging fine grains in a continuous network that surrounds islands of coarse grains

Diversification of plant chemical phenotypes is typically associated with spatially and temporally variable plant–insect interactions. Floral scent is often assumed to be the target of pollinator-mediated selection, whereas foliar compounds are considered targets of antagonist-mediated selection. However, floral and vegetative phytochemicals can be biosynthetically linked and may thus evolve as i

The extraordinary diversity of flowering plants has long captivated biologists andevolutionary ecologists. Plant-insect relationships are recognized as a major driverof this diversity, with pollinators playing a crucial role in angiosperm speciation andtrait diversification. Numerous observational and experimental studies have shownthat pollinators influence the evolution of floral traits—such as

Background: In recent years, a discourse on how to systematically consider and report threats to validity started to gain momentum within the empirical software engineering community. Aims: With this study, we aim to systematically underpin the current state of threats to validity practices in software engineering research. Method: We conduct a literature review comprising 91 papers awarded with t

PurposeThis paper aims to investigate the emergence of blockchain-enabled traceability in complex multi-tiered supply chains, focusing on the perspective of upstream suppliers. Blockchain technology receives attention for its potential to enable better traceability and thus sustainability risk management, yet there is limited empirical evidence on how actual implementation unfolds. We aim to under