BACKGROUND: Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this study was to assess the effect of HAART on patient mortality and tuberculosis inci

CONTEXT: The natural course of HIV disease progression among resource-poor patient populations has not been clearly defined.OBJECTIVE: To describe predictors of HIV disease progression as seen at an outpatient clinic in a resource-limited setting in rural Ethiopia.DESIGN: This prospective cohort study included all adult HIV patients who visited an outpatient clinic at Arba Minch hospital in South

Kronik/op-ed essay on developments among the 9/11 conspiracy theorists, '011 truth movement or 'truthers', and why they should be taken seriously even if they are totally wrong.

Results from the radiological environmental monitoring of the European Spallation Source (ESS) are presented for year 2020.Among the 63 environmental samples analysed for gamma emitting radionuclides, no elevated levels of anthropogenic radioactivity were observed. All samples (except two samples of lichen) had activity concentrations below the MDA for the natural radionuclides as well as 137Cs, a

Background: The same dosing schedule, 1000 SQ-U times three, with one-month intervals, have been evaluated in most trials of intralymphatic immunotherapy (ILIT) for the treatment of allergic rhinitis (AR). The present studies evaluated if a dose escalation in ILIT can enhance the clinical and immunological effects, without compromising safety. Methods: Two randomized double-blind placebo-controlle

Forest composition characteristic of the Mid-Holocene has survived on Hallands Väderö, an island nature reserve off the south west coast of Sweden. Current veteran Tilia and Quercus trees contribute to a remarkably rich biodiversity of fungi, bryophytes, lichens and insects. Understanding which potential factors influence Holocene vegetation dynamics can support efforts to protect biodiversity, bu

Molecularly imprinted polymers have been studied for a long time and have found useful applications in many fields. In most cases, small organic molecules are used as templates to synthesize imprinted polymers. In contrast to low molecular weight targets, large biological molecules and cells are more challenging to use as templates to synthesize cell-recognizing materials. This chapter presents an

The accurate processing of complex liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) data from biological samples is a major challenge for metabolomics, proteomics, and related approaches. Here, we present the pipelines and systems for threshold-avoiding quantification (PASTAQ) LC-MS/MS preprocessing toolset, which allows highly accurate quantification of data-dependent acquisit

Objective: Invasive treatment of intermittent claudication (IC) is commonly performed, despite limited evidence of its cost effectiveness. IC symptoms are mainly caused by atherosclerotic lesions in the superficial femoral artery (SFA), and endovascular treatment is performed frequently. The aim of this study was to investigate its cost effectiveness vs. non-invasive treatment. Methods: One hundre

The study describes findings from a community-based participatory and challenge-driven research programme, that aimed to improve health equity through a health promotion platform in an ethnically diverse low-income neighbourhood of Malmo, Sweden. Local residents, together with lay health promoters living in the area, were actively involved in the planning phase and decided on the structure and con

Predicting the impact of climate change on biodiversity requires understanding the adaptation potential of wild organisms. Evolutionary responses depend on the additive genetic variation associated with the phenotypic traits targeted by selection. We combine 5 years of cross-fostering experiments, measurements of resting metabolic rate (RMR) on nearly 200 wild collared flycatcher (Ficedula albicol

Purpose: This study aimed to describe extended collaboration in situations when an ambulance was called, as experienced by older patients, a significant other, and ambulance- and primary healthcare (PHC) centre personnel. Methods: The study used a phenomenological reflective lifeworld research (RLR) approach. Participants included in three specific situations with extended collaboration were inter

On 19 August 2015 the European Spallation Source (ESS) was approved by the European Commission as a European Research Infrastructure Consortium (ERIC). The purpose of the contribution is to answer the question about actual VAT treatment of transactions in which ESS is engaged and to make a conclusion whether the current rules contribute to the free movement of knowledge in Europe, also called a "f

BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) exposure has been linked to metabolic health outcomes such as obesity, and changes in adipokine hormones may be one of the underlying biological mechanisms. We prospectively evaluated the associations between prenatal and early childhood exposures to PFASs and adipokines in children.MATERIAL AND METHODS: PFAS concentrations were measured in se

Per- and polyfluoroalkyl substances (PFASs) are highly persistent in the environment and may cause depressed immune function. Previous studies have linked PFAS exposure to lower vaccine responses in children, but research in adults is limited. Therefore, the present study evaluated the associations between exposure to PFASs and serum antibody concentrations in adults vaccinated at age 28 years in