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Herpes simplex virus type 1 (HSV-1) delivers its genome into the host nucleus via docking of the viral capsid at the nuclear pore complex (NPC), a process mediated by the capsid vertex-specific complex (CVSC), composed of UL17, UL25, and UL36. While prior in vivo studies have implicated UL25 and UL36 in NPC interactions, their interpretation is complicated by indirect effects from viral traffickin

Hypoplastic left heart syndrome (HLHS) represents a severe spectrum of congenital cardiac malformations, which lead to systemic blood supply being dependent on patency of the arterial duct after birth. Antenatal diagnosis, advances in postnatal care and modifications of surgical palliation strategies have led to improved outcomes with the majority of patients born in the current era being expected

Objective: Emergency department (ED) staff need to rapidly establish accurate diagnosis and management for children with arrhythmias. Limited data are available on the presenting features, epidemiology and management of arrhythmias encountered in the ED. The aim of this study was to characterise the incidence, presenting features, management and outcomes of arrhythmias at a large tertiary children

The provision of safe care is complex and difficult to achieve. Awareness of what happens in real time is one of the ways to develop a safe system within a culture of safety. At Great Ormond Street Hospital, we developed and tested a tool specifically designed for patients and families to report harm, with the aim of raising awareness and opportunities for staff to continually improve and provide

Background: Congenital heart disease (CHD) is the most common organ anomaly in humans affecting approximately 1:125 newborns worldwide. Early diagnosis enables postnatal stabilisation and may improve outcomes, especially in critical CHD, in which the circulation is dependent on patency of the arterial duct. Detection of CHD in newborns remains incomplete and current screening programs do not aim t

IntroductionUse of long-term oxygen therapy (LTOT) for more than 15 h per day does not reduce mortality or hospitalizations, but may increase the risk of adverse events. We evaluated the relationship between daily oxygen use duration and adverse events, symptoms, and health status in patients on LTOT.MethodsThis was a cross-sectional survey study of a random sample (N = 650) of adults with ongoing

This book contributes to the emerging global discourse on sustainable entrepreneurship by highlighting its transformative potential to harmonise economic growth with environmental sustainability. It emphasises the role of innovative, sustainability‑driven entrepreneurs in reshaping production and consumption practices to achieve just and equitable economic, social, and environmental outcomes. By e

Ayatollah Ali Khamenei, who has served as Supreme Leader of the Islamic Republic of Iran since 1989, remains unchallenged as the most powerful figure within the country’s theocratic dictatorship. Now 85 years old, renewed attention is being drawn to persistent speculation about his declining health. As Iran prepares for an era without its leading figure, the opaque process of succession once again

Antibiotics are used to treat both humans and animals for both preventive and therapeutic purposes. The overreliance on and misuse of antibiotics has given rise to a stealth pandemic, known as antimicrobial resistance (AMR). Globally, they pose a significant threat to human, animal, and environmental health. Surveillance of antibiotic residues in the environment, especially in wastewater, for tack

This article compares India’s recently adopted child protection policy, Mission Vatsalya (2022), with its predecessor, the Integrated Child Protection Scheme (2009, 2014). The comparative analysis finds that many parts of Mission Vatsalya are ‘old wine in new bottles’, suggesting that adopting a new scheme was in large part a rebranding exercise. Some concerning changes, however, are visible: a di

BackgroundDietary shift is necessary for improving public health, mitigating climate change, and achieving the Sustainable Development Goals. Adaption of climate-friendly diets might prevent chronic diseases and reduce mortality; however, consuming diets with a low climate impact have been suggested to increase risk of some micronutrient deficiencies.ObjectivesThis study aimed to examine whether s

INTRODUCTION: Gambling harm is a widespread phenomenon affecting an increasing number of individuals. Understanding the concept of self-control is central to comprehending the nature of gambling problems.METHODS: Semi-structured in-depth interviews were conducted with ten individuals recruited through peer support associations in Sweden. The data was analysed using Interpretative Phenomenological

This study explores narratives about gambling problems and experiences of "rock bottom" through interviews with ten participants. The analysis generated three main themes. In A bumpy road-Plunging toward "rock bottom," participants described hitting "rock bottom" as something to avoid or being dragged there by self-hatred or dedication. In A split existence-Being at the "rock bottom," the experi

Background: Developmental exposures to neurotoxic insecticides, as pyrethroids and chlorpyrifos are of growing concern. Objective: To study associations between low prenatal and childhood exposure to pyrethroids and chlorpyrifos and motor skills at age 7. Materials and methods: Data consisted of sub-samples of women and children from the Odense Child Cohort; 883 mother-child pairs with maternal ur

Background: Tattoo inks are mixtures of organic and inorganic color pigments and having a tattoo may be adversely associated with biomarkers of male fecundity. Objective: To examine the association between tattoo exposure and biomarkers of male fecundity. Methods: Participants were young adult Danish males (aged 18–21 years) sampled from the Danish National Birth Cohort. Upon recruitment in 2017–2

Den 14 februari 2025 hölls vid Juridiska fakulteten vid Lunds universitet en konferens på temat kompetensfördelningen mellan allmän domstol och allmän förvaltningsdomstol. Konferensen arrangerades av Nätverket för förvaltningsprocessrätt och Lunds universitet. Som talare medverkare domare verksamma inom rättskipningen i Sverige och Finland samt forskare. Bland åhörarna fanns företrädare för rättsk

Episodic memories are not static - they shift and reshape as our surroundings evolve. One powerful mechanism for change are prediction errors, which arise when predictions about what is going to happen next do not match the actual input. This study investigated how the size of prediction errors - arising from predictions based on episodic memories - affects recognition memory and neural memory rep