In this paper we develop two models; the without shortages and the completely backlogging shortages with the price dependant demand rate under time value of money and inflation, finite time horizon and exponentially deterioration rate with the objective of maximizing the present worth of the total system profit. Using the dynamic programming method for each model, we are able to obtain different s

There has been a growing interest in research regarding monitoring a process through a regression model (called a profile) rather than a simple quality characteristic. This paper proposes a new monitoring scheme to simultaneously monitor the multivariate multiple linear profiles’ parameters. This scheme is based on the Shewhart control chart concept and only has one single (max-type) control chart

Conventional image-based process control schemes require distinct, detectable features (e.g., edges or textures). In the absence of such features, current methods fail or require additional preprocessing. They are also prone to false detections from random noise, dirt, or scratches on the surface. In addition, they often focus on pixel intensity differences, making them less effective for subtle s

This paper explores how pro-active government policies could promote artificial intelligence (AI) in healthcare for the public good. Building on insights from the literature on industrial policy, we argue that without clear conditions and guardrails to ensure future public benefit, state assistance and subsidies will be nothing more than corporate welfare with unpredictable, if any, societal benef

X-ray fluorescence emission spectroscopy is a powerful tool to gain chemical information on a wide variety of samples. Its combination with focused X-ray beams and translation stages enables X-ray fluorescence microscopy, generating quantitative distribution maps for sets of chemical elements, depending on incident photon energy and detector specifications. The use of synchrotron radiation for X-r

Background: The primary aim was to assess psychological distress in patients with longstanding hip and groin pain (LHGP) and compare them with healthy controls. The secondary aim was to explore the association between psychological distress and symptom duration, self-reported pain and symptoms in patients with LHGP. Methods: Seventy-two patients with LHGP and sixty-three controls were included. Th

We calculate the low-temperature spectral function of the symmetric single impurity Anderson model using a recently proposed dynamical exchange-correlation (xc) field formalism. The xc field, coupled to the one-particle Green’s function, is obtained through analytic analysis and numerical extrapolation based on finite clusters. In the Kondo regime, the xc field is modeled by an Ansatz that takes i

This study explored serious mental illness (SMI) in young adult offenders imprisoned for violent or sexual crimes, estimating the effects of neurodevelopmental disorders and early-life risk factors on the development of SMI, and its prospective long-term adverse outcomes. An all-male cohort of 266 violent offenders, assessed during imprisonment when aged 18–25 years (M = 21.8, SD = 1.9), was follo

This study leverages synchrotron radiation-based X-ray absorption photoemission electron microscopy (X-PEEM) to investigate non-metallic inclusions (NMIs) in ultra-high-strength steels. By acquiring Ca-L2,3-edge X-ray absorption spectra from six NMIs at both room temperature and 400 °C, we analyze their structural changes, chemical compositions, and phase transformations. To extract meaningful ins

Background: Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear. Results: This study showed that mPGES1 was highly expressed in the mouse uterus’s subluminal stromal cells at the implantation site. COX2-specific inhibitor Valdecoxib and mPGES1 selective inhibitor MK886 were u

Groundwater drought, as a form of hydrological drought, embodies the distinctive characteristics of the aquifer and human-induced disruptions within the hydrological system. The intricate nature of groundwater flow systems, coupled with challenges in acquiring field observations related to aquifers, poses significant challenges in quantitatively characterizing groundwater drought. The present pape

BACKGROUND: Assessing perceptions of occupational balance is essential in both clinical occupational therapy and research. Attempts to characterise occupational balance often arrive at multi-faceted explanations, including a variety of occupations, personal satisfaction, and time allocation.AIM: This study aimed to deepen the understanding of occupational balance as a phenomenon and investigate th

Deposition of basement membrane components, such as collagen IVα5, is associated with altered endothelial cell function in pulmonary hypertension. Collagen IVα5 harbors a functionally active fragment within its C-terminal noncollageneous (NC1) domain, called pentastatin, whose role in pulmonary endothelial cell behavior remains unknown. Here, we demonstrate that pentastatin serves as a mediator of

Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling. Extracellular matrix (ECM) deposition in pulmonary arteries (PA) is one of the key features of vascular remodeling. Emerging evidence indicates that the basement membrane (BM), a specialized cluster of ECM proteins underlying the en

Integrated conodont and carbon isotope data is presented from the Telychian (upper Llandovery, lower Silurian) from the Baicaoping section, Yunnan Province, southwestern China. Three conodont zonal units, in stratigraphically ascending order, the Pterospathodus eopennatus Superzone, Pterospathodus celloni Superzone, and the Pterospathodus amorphognathoides amorphognathoides Zone, are recognized in

The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessiv

The extracellular matrix (ECM) increasingly emerges as an active driver in several diseases, including idiopathic pulmonary arterial hypertension (IPAH). The basement membrane (BM) is a specialized class of ECM proteins. In pulmonary arteries, the BM is in close contact and direct proximity to vascular cells, including endothelial cells. So far, the role of the BM has remained underinvestigated in

Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive vascular fibrosis and inflammation are often present in PH, but the underlying mechanisms are still not well understood. Objectives: To identify a novel functional link between natural killer T (NKT) cell activation an

Copepods may contribute to harmful algal bloom formation by selectively rejecting harmful cells. Additionally, copepods and the chemical cues they exude, copepodamides, have been shown to induce increased toxin production in paralytic and amnesic toxin producing microalgae. However, it is unknown if diarrhetic shellfish toxin (DST) producers such as Dinophysis respond to copepods or copepodamides

Metal matrix composites (MMCs) possess excellent material properties due to the combination of metals and reinforcing phases, yet this reduces their machinability. Numerous studies have shown that, due to the ploughing effect of the cutting tool, the edge effect can directly impact the material removal mechanism and the generation of surface integrity. However, the influence of different cutting-e