Isolation and characterization of circulating tumor cells (CTCs) present a noninvasive alternative to monitor disease progression in individual patients. However, the heterogeneous lineage specificity of CTCs makes it difficult to isolate and identify possible CTCs by a liquid biopsy. Better label-free methods for the isolation of viable CTCs are needed. Our solution is a combined approach that is

Purpose: Small-bites suturing technique for laparotomy closure is now recommended as the standard of care. However, uptake of the practice remains slow. A medical technology called the SutureTOOL has been developed which can facilitate implementation of small-bites. The aim of the study was to compare the economic and clinical outcomes of laparotomy closure for patients using manual needle-driver

Galaxies are complex objects, yet the number of independent parameters to describe them remains unknown. We present here a non-parametric method to estimate the intrinsic dimensionality of large data sets. We apply it to wide-band photometric data drawn from the COSMOS2020 catalogue and a comparable mock catalogue from the HORIZON-AGN simulation. Our galaxy catalogues are limited in signal-to-nois

Soil aggregate stability has been asserted as an indicator of soil quality. Earthworms are essential for the stability of soil aggregates due to their activities, including burrowing and organic matter decomposition. In this study, we focused on how differences in plant litter quality influences earthworm abundance and composition and, subsequently, macroaggregate stability in an agroforestry ecos

Nitrous oxide (N2O) is the most important stratospheric ozone-depleting agent based on current emissions and the third largest contributor to increased net radiative forcing. Increases in atmospheric N2O have been attributed primarily to enhanced soil N2O emissions. Critically, contributions from soils in the Northern High Latitudes (NHL, >50°N) remain poorly quantified despite their exposure to r

DOPA Decarboxylase (DDC) has been proposed as a cerebrospinal fluid (CSF) biomarker with increased concentrations in Lewy body disorders (LBDs) and highest levels in patients receiving dopaminergic treatment. Here we evaluate plasma DDC, measured by proximity extension assay, and the effect of dopaminergic treatment in three independent LBD (with a focus on dementia with Lewy bodies (DLB) and Park

The intersection of Tolkien’s writing and his environmental agenda have long been studied and the Ents are easily identified as one of the envoys of environmental messages in The Lord of the Rings. The Ents are anthropomorphic Hybrids in their function within the narrative, which can lead to a paradox when considering that ecocritical theories rather disapprove of humanising tools to convey ecolog

Phthalates are widespread contaminants with differing chemical characteristics, which largely determine their product applications, and they can leach into the environment. Due to their endocrine disruptive properties at long-term low-level exposure, they propose a health threat to people that has been associated with several adverse health effects such as: decreased male fertility and impacts on

Phthalates and 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), bisphenols (BPs), parabens (PBs), and triclosan (TCS) are high-production-volume chemicals of pseudo-persistence that are concerning for the environment and human health. This study aims to assess the exposure to 10 phthalates, DINCH, and environmental phenols (3 BPs, 7 PBs, and TCS) of Slovenian men (n = 548) and lactating

ER-positive/HER2-negative (ERpHER2n) breast cancer classified as PAM50 HER2-enriched (ERpHER2n-HER2E) represents a small high-risk patient subgroup. In this study, we investigate genomic, transcriptomic, and clinical features of ERpHER2n-HER2E breast tumors using two primary ERpHER2n cohorts comprising a total of 5640 patients. We show that ERpHER2n-HER2E tumors exhibit aggressive clinical feature

Objective: To investigate whether tangential versus segmental portomesenteric venous resection (PVR) impacts surgical and oncological outcome in patients undergoing pancreatoduodenectomy for pancreatic cancer with portomesenteric vein (PMV) involvement. Summary Background Data: Current comparative studies on tangential versus segmental PVR as part of pancreatoduodenectomy for pancreatic cancer inc

Triple-negative breast cancer (TNBC) is a clinically challenging and molecularly heterogenous breast cancer subgroup. Here, we investigate the DNA methylation landscape of TNBC. By analyzing tumor methylome profiles and accounting for the genomic context of CpG methylation, we divide TNBC into two epigenetic subtypes corresponding to a Basal and a non-Basal group, in which characteristic transcrip

Arkitektur ses ofta som konsten att skapa permanenta byggnadsstrukturer. Men vad händer när detta bryts – när byggnader förfaller eller demonteras? Detta examensarbete utforskar samspelet mellan förfall och återbruk och utmanar konventionell bevarandepraxis genom att omfamna temporära och okonventionella lösningar. Studien utgår från Oltrepò Pavese i södra Lombardiet och fokuserar på två närligganArchitecture is often seen as the art of permanence, of creating structures meant to endure. But what happens when permanence is disrupted – when buildings fall into ruin or are dismantled? This thesis explores decay, reuse, and reassembly, challenging conventional preservation by embracing impermanence and unconventional outcomes. Set in the hills of Oltrepò Pavese in southern Lombardy, it focuse

There have been many studies on the Hungarian political climate already, but the majority of these approach it by only focusing on the state. Although this is important, the system contains other actors as well, such as various leftist oppositional associations. However, the non-classical leftist associations are still an under-researched topic within Hungary. This thesis aims to find out how do n

Insoluble tau aggregates within neurofibrillary tangles are a defining neuropathological feature of Alzheimer's disease (AD) and closely correlate with clinical symptoms. Although tau pathology can be assessed using tau positron emission tomography, a more accessible biomarker is needed for diagnosis, prognosis and tracking treatment effects. Here we present a new plasma tau species, the endogenou