Filtyp
Aim: To explore the lived experience of the trusting nurse–patient relationship among patients admitted to internal medicine wards. Design: A qualitative study guided by van Manen's hermeneutic phenomenological approach. Methods: Semi-structured interviews were conducted with fourteen hospitalised patients in a Danish University hospital in 2024. Data were analysed through thematic reflection. Res
Background: Age-related immunosenescence, also known as ‘inflammageing’, may impact the elderly’s ability to mount immune responses against cancers and compromise the effectiveness of immune checkpoint inhibition (ICI). In this context, data on tonsillar cancer (TC), a subset of head and neck squamous cell cancer (HNSCC), are lacking. Aims/objectives: To compare the presence/distribution and featu
COVID-19 convalescent plasma (CCP) obtained from recently recovered people is safe and effective against SARS-CoV-2. Currently available CCP is a “hybrid” product with antibodies from individuals who had both infection and vaccination (vaccine-boosted CCP). B-cell depleted patients are at risk of not producing antibodies after either infection or vaccination, hence conceivably among those who woul
This contribution deals with a specific ritual expression among the Sámi, the bear grave.Brown bears were sacred in the Sámi society. They were hunted, killed, and then consumed duringa feast. All bones of the killed bear were afterwards collected and carefully buried. At present, in theSwedish part of Sápmi, we have evidence of definite Sámi bear graves going back in time for onethousand years. TThis contribution deals with a specific ritual expression among the Sámi, the bear grave. Brown bears were sacred in the Sámi society. They were hunted, killed, and then consumed during a feast. All bones of the killed bear were afterwards collected and carefully buried. At present, in the Swedish part of Sápmi, we have evidence of definite Sámi bear graves going back in time for one thousand year
We study Frege proofs using depth-d Boolean formulas for the Tseitin contradiction on n \times n grids. We prove that if each line in the proof is of size M, then the number of lines is exponential in n/(log M)O(d). This strengthens a recent result of Pitassi, Ramakrishman, and Tan [2022 IEEE 62nd Annual Symposium on Foundations of Computer Science, 2022, pp. 445-456]. The key technical step is a
Purpose: To explore the association of frailty with mortality, functional outcome, and health status after out-of-hospital cardiac arrest.Methods: This is a cohort-based secondary analysis of the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial, an international, prospective, multicentre study. Frailty was assessed using the Clinical Frailty ScalePurpose: To explore the association of frailty with mortality, functional outcome, and health status after out-of-hospital cardiac arrest.Methods: This is a cohort-based secondary analysis of the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial, an international, prospective, multicentre study. Frailty was assessed using the Clinical Frailty Scale
Recent advances are transforming our understanding of brain fluid dynamics, highlighting cerebrospinal fluid (CSF) flow as a key process in brain waste clearance. While debates persist regarding its anatomical pathways and regulatory mechanisms, certain core principles have become widely accepted. CSF influx occurs primarily along periarterial spaces, solute clearance follows multiple routes, and
Background Postoperative pancreatic fistula (POPF) is a major complication after left pancreatectomy. The current International Study Group of Pancreatic Surgery classification has limitations, including heterogeneity in morbidity and high interobserver variability. This study aimed to assess POPF-related morbidity after left pancreatectomy and propose a refined classification system. Methods Pati
We give a general overview of what the scientific community refers to as “exocomets”. The general definition of exocomets, as presented in this work, is discussed and compared with Solar System comets and interstellar objects, addressing their detection around main-sequence stars as well as orbiting white dwarfs. We introduce the different types of exocomet observations, highlighting the differenc
Individuals born with low birth weight are at increased risk of type 2 diabetes, which potentially may be attributed to immature adipose tissue development and reduced levels of the insulin-sensitizing adipokine, adiponectin. This systematic review and meta-analysis synthesize data from 67 studies, comprising over 8000 individuals across various age groups, to examine the relationship between circ
This study investigates whether metaphors and similes are processed the same way or not. Comparison accounts of metaphor claim that metaphors and similes use the same cognitive mechanisms because metaphors are implicit similes, while Categorization accounts claim that the two figures of speech require different cognitive mechanisms. It is unclear which position has the most support. We address thi
Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2) translocation, which produces the fusion oncogene named SS18::SSX. Despite recent advancements in our understanding of synovial sarcoma biology, the cell-of-origin remains undefined. A mesenchymal stromal cell (MSC) specific CreERT2 line was employed to express SS18::SSX in
The present report from the ESE Educational Program on Parathyroid Disorders (PARAT Program) presents recent developments and novelties in the clinical care of parathyroid disorders in a question-and-answer format, based on a satellite workshop held in relation to the European Congress of Endocrinology in Stockholm, May 2024. The workshop focused on clinical aspects of 3 main themes: primary hyper
Introduction: Advanced endometriosis (stage III–IV, per the revised American Society for Reproductive Medicine (rARSM) classification of endometriosis) is associated with a range of pregnancy-related complications. Despite growing evidence, awareness of these risks remains limited among healthcare providers. Furthermore, the impact of endometriosis surgery prior to conception on pregnancy outcomes
Background: The clinical management of ER-positive/HER2-negative (ERpHER2n) breast cancer is complicated by a heterogeneous patient population, with some patients exhibiting endocrine resistance and an increased risk of recurrence. Among these high-risk subgroups, ERpHER2n Basal-like (ERpHER2n-Basal) breast cancer, as defined by PAM50 gene expression subtyping, remains poorly characterized due to
Background: Emerging evidence indicates that estrogen receptor-low (ER-low)/human epidermal growth factor receptor 2 negative (HER2-) breast cancer (BC) may more closely resemble ER-negative (ER-zero, < 1%) rather than ER-positive disease in terms of biological and clinicopathological characteristics. In Sweden, ER-low (ER 1–9%) BC is managed as triple-negative breast cancer (TNBC) and is thus eli
In 2015, the United Nations General Assembly unanimously adopted the 2030 Agenda for Sustainable Development with 17 Sustainable Development Goals and 169 targets. This agreement sets a 15-year plan to steer the world towards a more sustainable and equitable trajectory. However, as we have passed halfway through this agenda, the world is far from achieving most goals within this timeframe. Such la
In this paper I evaluate the feasibility of reconstructing Viking Age sailing routes through experimental and ethnographic fieldwork onboard traditional Norwegian boats, focusing on aspects of Viking Age route choice, risk judgement, and the location of possible anchorages and harbours. The goal with this approach is to reconstruct the ‘scapes’ of Viking Age seafaring: the seafaring routes and env
Background: Acute aortic syndrome (AAS) is a life-threatening condition reported as often misdiagnosed. Advancements in CT availability and diagnostic algorithms, including high-sensitivity troponin and D-dimer for acute coronary syndrome (ACS) and pulmonary embolism (PE), may reduce AAS misdiagnosis, but the impact remains unclear. This study evaluated the incidence, characteristics, and clinical
Background: Detecting and monitoring monoclonal free light immunoglobulin chains in serum is important for managing patients with B-cell neoplasms. Established methods have relied on immunochemistry, with monoclonality determined through an abnormal ratio of free kappa and lambda chains and an increased concentration of the involved chain. This indirect approach has limitations. Mass spectrometric
