Filtyp
BACKGROUND: Our aim was to examine the prevalence and characteristics of difficult-to-treat HIV in the current Swedish HIV cohort and to compare treatment outcomes between people with difficult and non-difficult-to-treat HIV.METHODS: In this cross-sectional analysis of the Swedish HIV cohort, we identified all people with HIV currently in active care in 2023 from the national register InfCareHIV.
When evaluating quantities of interest that depend on the solutions to differential equations, we inevitably face the trade-off between accuracy and efficiency. Especially for parametrized, time-dependent problems in engineering computations, it is often the case that acceptable computational budgets limit the availability of high-fidelity, accurate simulation data. Multi-fidelity surrogate modeli
Highly accurate numerical or physical experiments are often very time-consuming or expensive to obtain. When time or budget restrictions prohibit the generation of additional data, the amount of available samples may be too limited to provide satisfactory model results. Multi-fidelity methods deal with such problems by incorporating information from other sources, which are ideally well-correlated
This work proposes a Bayesian inference method for the reduced-order modeling of time-dependent systems. Informed by the structure of the governing equations, the task of learning a reduced-order model from data is posed as a Bayesian inverse problem with Gaussian prior and likelihood. The resulting posterior distribution characterizes the operators defining the reduced-order model, hence the pred
A non-intrusive reduced basis (RB) method is proposed for parametrized nonlinear structural analysis undergoing large deformations and with elasto-plastic constitutive relations. In this method, a reduced basis is constructed from a set of full-order snapshots by the proper orthogonal decomposition (POD), and the Gaussian process regression (GPR) is used to approximate the projection coefficients.
In solid mechanics, linear structures often exhibit (local) nonlinear behavior when close to failure. For instance, the elastic deformation of a structure becomes plastic after being deformed beyond recovery. To properly assess such problems in a real-life application, we need fast and multi-query evaluations of coupled linear and nonlinear structural systems, whose approximations are not straight
In this paper, goal-oriented error estimation for Timoshenko beams on Pasternak foundation, which involves double shear effect, is performed. The constitutive relation error (CRE) estimation is used in finite element analysis (FEA) to acquire strict bounds on quantities of interest. Due to the coupling of the displacement field and the internal force field in the equilibrium equations of the beam,
Purpose - The purpose of this paper is to acquire strict upper and lower bounds on quantities of slender beams on Winkler foundation in finite element analysis. Design/methodology/approach - It leans on the dual analysis wherein the constitutive relation error (CRE) is used to perform goal-oriented error estimation. Due to the coupling of the displacement field and the stress field in the equilibr
On the basis of the dual variational formulation of a class of elliptic variational inequalities, a constitutive relation error is defined for the variational inequalities as an a posteriori error estimator, which is shown to guarantee strict upper bounds of the global energy-norm errors of kinematically admissible solutions. A numerical example is presented to validate the strictly bounding prope
A method is proposed for the solution of boundary-value problems of linear and non-linear 2mth-order Fredholm integro-differential equations. A set of algebraic equations are obtained after introduction of Gauss–Lobatto quadrature and the generalized differential quadrature analog into the weak form description of a Fredholm integro-differential equation. Numerical examples are presented to demons
A procedure to identify the imperfection in thin plates is proposed in this paper. The modified potential energy principle, which serves as the theoretical basis of the identification procedure, is improved to allow for the experimental measurements in static tests. Several typical examples are studied to illustrate the effectiveness of the procedure.
In this paper, a goal-oriented error estimation technique for static response sensitivity analysis is proposed based on the constitutive relation error (CRE) estimation for finite element analysis (FEA). Strict upper and lower bounds of various quantities of interest (QoI) that are associated with the response sensitivity derivative fields are acquired. Numerical results are presented to assess th
For model verification which is mainly focused on the control of discretization errors of numerical results, a posteriori error estimation plays an important role in various numerical tools such as the finite element method. The outputs of interest are usually converted into integral functionals over the problem domain for a posteriori error analysis. Among the available techniques for goal-orient
De samhälleliga och mänskliga kostnaderna för långvarigt utanförskap är förödande.Exemplet med den somaliska integrationen i Minnesota i USA visar att det skulle kunna vara annorlunda – men det kräver att vi gör upp med vår misstänksamhet mot etniskt företagande, skriver Benny Carlsson och Andreas Johansson Heinö.
Two iron complexes featuring the bidentate, nonconjugated N-heterocyclic carbene (NHC) 1,1′-methylenebis(3-methylimidazol-2-ylidene) (mbmi) ligand, where the two NHC moieties are separated by a methylene bridge, have been synthesized to exploit the combined influence of geometric and electronic effects on the ground- and excited-state properties of homoleptic FeIII-hexa-NHC [Fe(mbmi)3](PF6)3 and h
The field of ultrafast science is dependent on either ultrashort laser pulse technology or ultrafast passive detection. While there exists a plethora of sub-picosecond laser pulse solutions, streak cameras are singular in providing sub-picosecond passive imaging capabilities. Therefore, their use in fields ranging from medicine to physics is prevalent. Streak cameras attain such temporal resolutio
Defining psychiatric and mental health nursing has been a challenge for decades, and it is still difficult to find a comprehensive definition. We have identified a possibility to clarify psychiatric and mental health nursing based on humanistic philosophy in a general psychiatric care context. The aim was therefore to identify and synthesize the theoretical frameworks from which psychiatric and me
Det finns ett ganska stort antal bestämmelser om att förvaltningsmyndigheter – ofta organiserade som domstolsliknande nämnder – ska ha medverkan av ordinarie domare. I detta bidrag ges en översikt över när lagstiftningen kräver sådandomarmedverkan. Dessutom diskuteras vad ordinarie domares uppdrag i sådana organ innebär praktiskt och principiellt, främst i statsrättsligt och förvaltningsrättsligt
The doctorate forms the basis for academic careers and the regeneration of academia, and has increasingly become important for other sectors of society. The latter is reflected in efforts on institutional, national as well as supranational levels to change and adapt the doctoral degree to new expectations. As doctoral education is embedded in research, changes in governance and funding of research
Aim: In neuroendocrine cells, large dense-core vesicles (LDCVs) undergo highly regulated pre-fusion processes before releasing hormones via membrane fusion. Significant heterogeneity has been found for LDCV population based on the dynamics of membrane fusion. However, how the pre-fusion status impacts the heterogeneity of LDCVs still remains unclear. Hence, we explored pre-fusion determinants of h
