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After common belief the impairment of nerve conduction seen with multiple sclerosis has to do with uncovering of internodal potassium channels. Therefore, suitable potassium channel blockers like 5-methoxypsoralen can alleviate functional deficits due to multiple sclerosis. This has been demonstrated by single tests under well-defined laboratory conditions and by further clinical single trials. Wi

The effects of the medicinal plant rue (Ruta graveolens L.) on MS-related visual-field defects was tested. In five of nine patients the scotomata were reduced by a single dose of an aqueous extract of 3 g of the drug; the effect was reversible, appearing after only about two hours and lasting for one to two days. There was no detectable action in four patients. In no case were undesirable side eff

The effects of myoglobin on renal microcirculation were studied in anesthetized rats subjected to hemorrhagic hypotension. Capillary flow distribution was determined by allowing two dyes to circulate for 3 and 1 min, respectively, freezing the left kidney and quantifying the dye distribution in histological sections by analyzing the distances of regularly spaced test points to the next dye-labeled

Background. The debate about increased welfare and health service costs is well-known in relation to the growing ageing population. Over the past thirty years, ageing in place has been the guiding principle for policies concerning older people and housing in Sweden and other Western countries. Sweden is among the countries in the European Union and internationally whose populations have the longes

The primary aim of this study is to assess the significance of top management commitment in the context of Lean 4.0 implementation within the pharmaceutical manufacturing industry in Ghana. The study seeks to understand and evaluate the overall effectiveness and achievements associated with adopting Lean 4.0. Employing a positivist mindset, the research utilizes an explanatory quantitative researc

Governments encourage cultural entrepreneurship in various ways, including by so-called tax incentives. Tax incentives are tax benefits for certain persons or activities. Most well known in relation to cultural policy are tax incentives for donations. The design of these tax incentives varies between countries. Not only may domestic tax incentives for donations be important for cultural organizati

Disadvantaged areas may prompt or force older people to relocate due to a lack of services, the presence of crime, and area unattractiveness, but knowledge in this area is insufficient. The aim was to investigate whether older adults living in different types of disadvantaged areas in Sweden were considering moving away from the area, and to explore similarities and differences in underlying resid

I civilprocessrätten är taleformerna, möjligheten att göra taleändringar och reglerna om rättskraft centrala, men de anses ofta svåröverskådliga. Här ges en översikt över rättsläget med fokus på de viktigaste frågorna. Bland annat behandlas när en prestation måste vara förfallen till fullgörelse för att en fullgörelsetalan ska kunna väckas, hur förutsättningarna för att väcka en fastställelsetalan

The efficiency of translation termination is determined by the nature of the stop codon as well as its context. In eukaryotes, recognition of the A-site stop codon and release of the polypeptide are mediated by release factors eRF1 and eRF3, respectively. Translation termination is modulated by other factors which either directly interact with release factors or bind to the E-site and modulate the

BACKGROUND: Allergic contact dermatitis (ACD) from protective gloves is often caused by rubber additives, such as accelerators. However, while accelerator-free rubber gloves are available, they still cause ACD in some individuals.OBJECTIVES: A new allergen, 2-cyаnоethyl dimethyldithiocarbamate, (CEDMC), has recently been identified in accelerator-free gloves, and we here provide a first in vitro c

The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. How HUSH and MORC2 operate alongside DNA methylation, a central epigenetic regulator of repeat transcription, remains largely unknown. Here we interrogate this relationship in human neural progenitor cells (hNPCs), a soma

You want to run an experiment where you anticipate finding a treatment effect.How large should your sample size be to have a reasonable chance of detectingsignificant results? In this manuscript, I present and explain the Stata code I use toaddress this question. The code uses simulations to conduct power analyses,offering a flexible alternative to the commonly used analytical tools. Unliketraditi

Variations in solar activity have been proposed to play an important role in recent and past climate change. To study this link on longer timescales, it is essential to know how the Sun has varied over the past millennia. Direct observations of solar variability based on sunspot numbers are limited to the past 400 years, and beyond this we rely on records of cosmogenic radionuclides, such as 14C a