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Ett nytt sätt att skapa modellhjärnor i labbet När man bedriver forskning på celler i ett labb, så är det viktigt att cellerna faktiskt beter sig som de gör i kroppen. Labbmiljön för celler, är däremot oftast ganska långt ifrån den miljön de normalt upplever i din kropp, vilket har gett upphov till idén om 3-dimenstionella cellodlingar. 3D-Odlingar är idag förhållandevis utbrett, med ett brett ar
The baker’s yeast, Saccharomyces cerevisiae (S. cerevisiae) was studied and genetically engineered. This was to enhance the transamination step of the biochemical reaction cascade towards the production of capsaicin. Inherent reductases were identified and twelve of them knocked out via homologous recombination. Using the CRISPR/Cas9 technology, the Green Fluorescence Protein (GFP) gene was introd
Jordbruksmarken i Sverige är en stor anledning till varför en stor mängd kväve och fosfor transporteras till vattendrag, sjöar och hav. Näringstransporten medför konsekvenser för miljön då växtorganismers förutsättningar förändras och övergödning sker. Våtmarker är ett naturligt inslag i miljön som har näringsrenande egenskaper gällande kväve och fosfor. Under det senaste seklet har uppemot en fjäThe agricultural land in Sweden is a major reason why a large amount of nitrogen and phosphorus is transported to rivers, lakes and the sea. Nutrient transport has consequences for the environment as the conditions for plant organisms change and eutrophication takes place. Wetlands are a natural part of the environment that have nutrient removing properties regarding nitrogen and phosphorus. Durin
Title: Critical Supply Chain Factors for Scaling a Startup -- A Case Study in the Industry of Semiconductors Author: Pontus Landgren Supervisors: Bertil Nilsson, Lund University, Faculty of Engineering & Lennart Moberg, Acconeer AB Background: A well implemented supply chain strategy aligned with the company's overall strategy is a prerequisite in order to successfully scale a startup.
Obtaining DNA sequences is a time-consuming task, which typically requires one or several days for completion. One way of reducing analysis times is to be satisfied with long-range sequence patterns on the order of thousands of base pairs. DNA barcoding is a DNA-characterising technique that works according to this principle. It does so by using fluorescence microscopy to visualise long-range sequ
To optimize the weights in an artificial neural network most methods rely gradients, which are not always obtainable or desirable. Evolutionary algorithms are instead based on Darwinian evolution where no derivative is needed. These algorithms have a set of strategy parameters that can be dynamically updated during the search to increase performance. Two ways of updating the parameters are the so
Purpose: The purpose of this essay is to examine the different relationships between the auditor and its clients and how this relationships affects the quality of the audit. Theoretical perspectives: The theoretical framework is based on a description of relationships based on Duff (2014) and a description of audit quality which is partly based on Tepalagul & Lin (2015) and Wright & Wrigh
Due to a warming climate, tundra ecosystems are subject to shrub and treeline expansions which could lead to increased above- but decreased belowground carbon (C) stocks. An observed low soil C stock in some subarctic forests and tall shrublands has been suggested to be induced by priming of organic matter decomposition, possibly mediated by ectomycorrhizal fungi. On the other hand, the higher bel
Androgen receptor (AR) is expressed in all stages of prostate cancer progression, including in castration-resistant tumors. Eliminating AR function continues to represent a focus of therapeutic investigation, but AR regulatory mechanisms remain poorly understood. To systematically characterize mechanisms involving microRNAs (miRNAs), we conducted a gain-of function screen of 1129 miRNA molecules i
Zöller B, Li X, Sundquist J, Sundquist K. (Center for Primary Health Care Research, Lund University, Malmö, Sweden; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA). Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden. J Intern Med 2010; doi: 10.1111/j.1365-2796.2010.02326.x. ABSTRACT.: Objective. This is
Over the past few years, information technology has changed the way we live, work, and communicate with each other. The two outstanding trends of Internet and cellular telephony growth will now enter a new phase when the two technologies converge into 2.5 and 3G networks. The success of cellular telephony is due to the mobility factor, and the success of the Internet is due to its architecture, wh
(2004:5) Löser immaterialrättskonsumtion och tvångslicenser aidsproblem i världens länder? Denna artikel är en direkt uppföljning av 2003 års föreläsning för Nordisk Immaterialrättsförening och granskar om dagens immaterialrättssystem förhindrar att u-ländernas hälsokris kan lösas. Den immaterialrättsliga konsumtionen kommer i förgrunden, men möjligheterna att använda andra immaterialrättsliga me
A Cochrane metaanalysis and a study performed on children have recently confirmed that therapeutic hypothermia does not improve outcome after severe traumatic brain injury (TBI). TBI is not comparable to a short episode of global ischemia, where therapeutic hypothermia has been shown to improve outcome. The difference may be explained by the fact that hypothermia-induced stress after a traumatic b
Abstract Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies w
The Middle Ages in archaeological perspective: Review of Øystein Ekrolls teaching book on medieval archaeology in Norway, "Ei anna historie - norsk mellomalder i arkeologisk lys" (Trondheim 2006).
