Background: Patients with irritable bowel syndrome (IBS) are often interested in dietary interventions as a means of managing their symptoms. However, the relative efficacy of available diets for the management of IBS is unclear. We aimed to examine the relative efficacy of various dietary interventions in IBS. Methods: For this systematic review and network meta-analysis we searched MEDLINE, EMBA

Glycopolymers are versatile materials for biomedical and healthcare applications, e.g., as carrier and polymeric therapeutics. Especially, the topology and surface composition of such materials play a key role in being promising materials in the anti-amyloidogenic interventions. Herein, 2nd and 3rd generation of pseudo-glycodendrimers (PGDs), based on hyperbranched polyester core with different su

Major Depression (MD) and General Anxiety Disorder (GAD) are the most common mental health disorders, which typically are assessed quantitatively by rating scales such as PHQ-9 and GAD-7. However, recent advances in natural language processing (NLP) and machine learning (ML) have opened up the possibility of question-based computational language assessment (QCLA). Here we investigate how accurate

Double cones have been described in the retinae of both fishes and tetrapods. While fish double cones are two closely attached single cones, the two members of tetrapod double cones each evolved to be distinctly different from all single cones.

Semiconductors use on-chip components, referred to as instruments, for test, debugging, firmware programming, configuration and other important functions. The instruments are needed to ensure proper device operation, however, they may be exploited by an adversary in an attack. With many different actors involved in semiconductor development and manufacturing, it becomes important to restrict acces

The evolution of reproductive isolation is a key evolutionary process, but the factors that shape its development in the early stages of speciation require clarification. Here, using a meta-analysis of 34 experimental speciation studies on arthropods, yeast and vertebrates, we show that populations subject to divergent selection evolved stronger reproductive isolation compared with populations tha

This paper proposes a D-band patch antenna featuring four parasitic elements and a loaded superstrate layer. Inspired by a previous parasitic patch antenna design, the new structure is synthesized from scratch using characteristic mode analysis. The new design features different operating principles that enable low-cost single-layer fabrication on PCB HDI technology, while retaining wideband opera

Chaperones may retard the aggregation of other proteins and increase their solubility. An important goal is a thermodynamic understanding of such an action. Here, the chaperone DNAJB6b (JB6) is found to suppress amyloid formation of the protein α-synuclein (α-syn) leading to a reduced rate of fibril formation and an increase in apparent solubility of α-syn. These findings were reached at mildly ac

Background and Aims: No-touch saphenous vein harvesting may enhance graft patency and improve clinical outcomes after coronary artery bypass grafting (CABG). Methods: In this registry-based, randomized trial, patients undergoing CABG were randomly assigned to no-touch or conventional harvesting. The primary composite outcome was the proportion of patients with occluded/stenosed >50% vein graft on

The live microbiota of tea has not been extensively investigated. This study aimed to identify the live, culturable microbiota from four types of tea with varying oxidation levels, before and after brewing. Tea leaves and brews from oolong and fermented teas were analyzed for total viable counts of aerobic bacteria, lactobacilli, fungi, and Enterobacteriaceae. Cultivation was performed and isolate

Background: Serum 1,3-β-d-glucan (BDG) tests are frequently used for diagnosing invasive candidiasis. However, BDG tests remain negative in many patients with candidemia, and factors influencing the probability for positive test results are poorly understood. Objectives: To study clinical and microbiological factors predictive of a positive BDG test, as well as the association of a positive BDG te

This longitudinal observational study aimed to determine if ventricular dimensions of the athlete's heart remain balanced and proportional to peak oxygen uptake (VO2peak) following long-term deconditioning in elite athletes. Fourteen mixed-type male athletes (7 soccer, 7 handball players) were prospectively evaluated with cardiac magnetic resonance imaging and cardiopulmonary exercise testing whil

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of pain and sedation management for screening or treatment of retinopathy of prematurity in preterm infants compared to placebo, no intervention, or other interventions.

The Schöningen 13II-4 archaeological site in Germany holds title to the most complete Paleolithic wooden hunting spears ever discovered, yet its age has never been properly settled. Initial estimates placed the site at around 400,000 years; this age was later revised to roughly 300,000 years. Here, we report age estimates for the “Spear Horizon” based on amino acid geochronology of fossils obtaine