Galectins are a family of carbohydrate-recognising proteins involved in regulation of cell adhesion and cell signaling, leading to roles in e.g. cancer progression, fibrosis, and ulcerative colitis. Glycomimetic galectin inhibitors based on different molecular scaffolds are known and have demonstrated effects from cell experiments to the clinic. Presented here is the synthesis and evaluation of 3-

Although financial stressors are implicated as risk factors for suicidal behavior, these associations might be confounded by other factors. Furthermore, a move toward high-risk subgroup definition is necessary. The authors used Swedish national registry data to examine the associations between receipt of social welfare, unemployment benefits, or early retirement (N = 627,745-2,260,753) with suicid

Avoiding severe global warming requires large-scale removals of atmospheric carbon dioxide. Forest regeneration offers cost-effective carbon removals, but annual rates vary substantially by location and forest age. Here we generate grid-level (~1-km2) growth curves for aboveground live carbon in naturally regrowing forests by combining 109,708 field estimates with 66 environmental covariates. Acro

In celebration of the excellence of articles published in the Journal of Comparative Physiology A, Editors’ and Readers’ Choice Awards are annually conferred to the top papers in the categories Original Research Paper and Review/Review-History Article. The recipients of the 2025 Editors’ Choice Awards were selected based on votes cast by the Editorial Board on articles published in 2024. In the ca

The way in which the large-scale cosmic environment affects galactic properties is not yet understood. Dark matter haloes, which embed galaxies, initially evolve following linear theory. Their subsequent evolution is driven by non-linear structure formation in the halo region and in its outer environment. In this work, we present the first study where we explicitly control the linear part of the e

Dynamic interference is an elusive strong-field effect where photoelectrons from intense laser pulses interfere in time, forming rich kinetic energy patterns. Here, we present the first experimental demonstration of isolated dynamic interference using a novel two-color scheme: chirped laser-assisted dynamic interference. Isolation was achieved with a crossed-polarization setup combining an extreme

Hydrodynamic cavitation take place in high-pressure homogenizer (HPH) valves. Cavitation wear, free radical formation and ultrasonic emissions are linked to the cavitation intensity. Cavitation intensity is also a key factor to understand any effect cavitation might have on particle breakup. Based on an approach used in previous studies on other devices, this contribution applies and tests a model

A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero)arenes is reported. This pragmatically focused study employs a unique Ag–Ni electrocatalytic platform to overcome numerous limitations that have plagued this strategically powerful transformation. In its optimized form, coupling partners can be combined i

This study aims to develop a comprehensive model that accurately represents the perceptual system of drivers and provides insights into their behavior. Existing models, namely the Skill-Rule-Knowledge model and the dynamic driving task model, were integrated. This integrated model successfully elucidates the sequential processes involved in sensation reception, recognition, judgment, and control.

Biodiversity Credits have received substantial attention as an innovative financial mechanism that can attract private financial capital towards biodiversity conservation and restoration. To explore this potential, the thesis examines how key market actors perceive the drivers and incentives (RQ1), as well as barriers and challenges (RQ2) of this emerging market. To answer these questions, a quali

This study examines vehicle interiors in terms of display configuration and seat orientation from a user experience viewpoint using a driving simulator. Sixteen volunteers were sat in the driver’s seat to evaluate visibility and mental comfort scores of three display configurations used in the vehicle (i.e., floating, flush, and large display). Another sixteen volunteers were sat in the passenger’

The driver of a conditionally automated vehicle equivalent to level 3 of the SAE is obligated to accept a takeover request (TOR) issued by the vehicle. Considerable research has been conducted on the TOR, especially in terms of the effectiveness of multimodal methods. Therefore, in this study, the effectiveness of various multimodalities was compared and analyzed. Thirty-six volunteers were recrui

In several circumstances, a level-three automated vehicle cannot continue driving in an automated driving mode and requests a human driver to take over. In this study, a series of experiments to examine how to provide a TOR was conducted. First, for forty-one persons, a HUD icon, earcon, seat vibration, and combinations were compared. The results indicated that the HUD icon-earcon and HUD icon-sea