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Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety

Background: Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxiety disorders. However, up to 50% of patients do not achieve sufficient symptom relief. Identifying patient characteristics predictive of higher post-treatment symptom severity is crucial for devising personalized interventions to avoid treatment fail

Characteristics of children with ataxic cerebral palsy

Background: To compare the characteristics, functional levels, and comorbidities of children with ataxic cerebral palsy (CP), with those of children with other CP subtypes. Methods: A cross-sectional study of children with CP born between 2000 and 2019 as reported in the Scandinavian national CP follow-up programmes and quality registries. Data for age, sex, levels of the Gross Motor Function Clas

The LEADING guideline : Reporting standards for expert panel, best-estimate diagnosis, and longitudinal expert all data (LEAD) methods

Accurate assessments of symptoms and illnesses are essential for health research and clinical practice but face many challenges. The absence of a single error-free measure is currently addressed by assessment methods involving experts reviewing several sources of information to achieve a best-estimate assessment. This assessment method is called the Expert Panel method in medicine, and the Best-Es

Unveiling uncertainties in soil organic carbon modeling : the critical role of climate response functions

Accurately simulating soil organic carbon (SOC) dynamics is essential for carbon-related assessments. Process-oriented SOC models employ temperature (f(T)) and soil moisture (f(W)) response functions derived from specific conditions to simulate SOC responses to climate change, yet are widely applied in regional and global-scale studies. How these functions affect regional SOC simulations remains u

Delivery of Ulva rigida extract by bicontinuous cubic lipid nanoplatforms for potential photodynamic therapy against pancreatic cancer

Ulva rigida is a widely available marine algae representing a valuable biomass from which natural photosensitizers (chlorophylls) can be obtained in an environmentally friendly manner using a green microwave-assisted extraction technique. If properly loaded in biocompatible nanoformulations, such highly hydrophobic chlorophylls with photosensitizing activity may constitute effective drugs useful i

Prophetic Political Theology : Daniel Bensaïd's Alternative Radicalism

This article probes the writings of the Jewish Trotskyist thinker Daniel Bensaïd (1946–2010) in light of recent debates on political theology. In contrast to what is sometimes explicitly referred to as ‘apocalyptic political theology’, it makes a case for what may be described as a ‘prophetic political theology’. Yet it is not obvious to claim Bensaïd as a proponent for such a project, since he ex

Exploring jets with respect to the reaction plane in heavy-ion collisions with XSCAPE

The aim of this thesis is to explore jets traversing the Quark-Gluon Plasma (QGP)created in Pb-Pb collisions. This is done in the simulation program XSCAPE with a center of mass energy of 2.76 TeV. By categorising the jets by their azimuthal angle with respect to the event plane angle, the path length dependence of the energy loss was studied. The path length classification was described with the

Medium-dose irradiation impairs long-term hematopoietic stem cell functionality and hematopoietic resilience to cytotoxic stress

Irradiation and 5-fluorouracil (5-FU) are widely utilized tools in hematopoietic research to generate myeloablation and assess blood recovery dynamics. A comprehensive understanding of their effects on the hematopoietic system is essential for optimizing therapeutic strategies, refining experimental models to modulate hematotoxicity, and interpreting research outcomes. Despite their widespread app

Fallbeskrivning : yngling överlevde direktträffar av kniv i hjärta och lunga

In Sweden, penetrating injuries to the lung and especially to the heart are fortunately rare. We hereby present a case-report on a young man who was stabbed in the right lung and heart. The paramedics arrived at the scene one minute after the alarm and instituted mechanical ventilation and fluid infusion. Ten minutes later the young man arrived at the emergency department. By then the patient was

Childhood exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiometabolic indicators in childhood and adolescence : findings from a cohort study in rural Bangladesh

Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiovascular diseases in adulthood, but studies examining childhood origins are scarce. Objective: To examine associations of childhood PAH exposure with cardiometabolic risk indicators in childhood and adolescence along with differences by sex. Methods: Urinary PAH metabolites [Σ1,2,3-hydroxyphenanthrene (Σ

Fetal exposure to a mixture of endocrine-disrupting chemicals and biomarkers of male fecundity : A population-based cohort study

Background: Fetal exposure to endocrine-disrupting chemicals (EDCs) has been associated with reduced male fecundity, but with few studies considering chemical mixtures. Objectives: We assessed the association between fetal exposure to a mixture of EDCs and biomarkers of male fecundity in young adulthood. Materials and methods: The study population comprised 841 young adult males enrolled in the Fe

pre-SUCCECS : Lessons learned from implementing resuscitation and stabilisation with an intact cord during caesarean sections – Focus group discussions with implementation teams

Objective: The primary aim of this study was to explore the lessons learned from implementing a procedure of resuscitation and stabilization with an intact umbilical cord for preterm and term infants requiring resuscitation or stabilization during emergency caesarean sections. Methods: Data were collected by two focus group discussions and one individual interview. Participants were members of imp

Moral distress among maternity and neonatal healthcare workers during the COVID-19 pandemic in Sweden : Results from the COPE staff longitudinal cohort study

Introduction: Moral distress arises when healthcare workers face difficult decisions without adequate information and/or when patient care is compromised due to limited resources, communication issues, or altered work routines in exceptional circumstances. While moral distress in maternity and neonatal healthcare workers (MNHCWs) has been noted, its prevalence, intensity, and impact on well-being

Reversal of Roux-en-Y Gastric Bypass to Normal Anatomy-Experience of 70 Patients

BACKGROUND: A limited subset of patients undergoing Roux-en-Y gastric bypass (RYGB) may develop intractable symptoms that ultimately require reversal to normal anatomy. Existing literature on this subject is characterized by small cohort sizes, substantial variation in surgical techniques, and limited follow-up durations. However, this study presents the largest single-center series to date, compr

A Reliabilism without Counterexamples and Reference Class Problems

In this article, I present a modified reliabilist theory of knowledge which purports to solve many of the problems currently facing standard reliabilism. With the help of a dispositionally construed reliabilist theory of knowledge and justification (DRK and DRJ), tentative responses to the following problems for reliabilism are offered: The New Evil Demon Problem, The Clairvoyance Problem, The Mr.

Ultrasound-assisted regeneration of ion exchange resins for efficient detoxification of lignocellulosic hydrolysate in biorefinery

Resin adsorption is an effective technology for the fermentable sugar slurry detoxification in lignocellulosic biorefinery, but with the great limitation of the loss of resin capacity from inhibitor contamination and the extensive use of acid and base solutions for their regeneration. In this study, we developed a green and practical method with ultrasound assisting the depletion of poisoned resin

Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) emerges from mutant KRAS-harboring but dormant low-grade pancreatic intraepithelial neoplasia (PanIN). To examine the role of oxidative stress, a putative PDAC risk factor, we established an organoid-based transformation system. Although the prototypic oxidant H2O2 induced organoid transformation, its effect was nonmutational and was mediated by the oxidant-

Circulating protein biomarkers and their association with vulnerable plaque characteristics – a PROSPECT II substudy

Background: In the PROSPECT-II study, near infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) was used to characterize atherosclerotic plaques in the coronary arteries. NIRS-derived lipid core burden index (LCBI) and IVUS-derived plaque burden (PB) were able to identify plaques strongly associated with adverse cardiovascular events. Aim: Our aim was to identify biomarkers associated

Statistical volume element generation for paperboard based on X-ray computer tomography images

The macroscopic response governed by a statistical volume element, generated from 3D X-ray computer tomography images of paperboard, is explored. The statistical volume element, which consists of fibres and void, is derived from X-ray computer tomography images. Two filters for computing intensity fields and intensity gradients have been implemented and compared. Using an intensity threshold, the