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Background: We aimed to determine corticosteroid (CS) use in paediatric inflammatory bowel disease (PIBD, < 18 years), which remains common despite recommendations for limited use and the emergence of steroid-sparing therapies. Methods: We conducted a study of all children in Sweden diagnosed with CD (n = 2460) or UC (n = 2470) in 2006–2022. Nationwide health registers provided annual individual-l
GOALS: To assess the incidence, type, and severity of infections in patients with IBD before and after starting thiopurine therapy.BACKGROUND: Thiopurines have been used for decades in the treatment of inflammatory bowel disease (IBD), yet real-world data regarding the extent and types of infections associated with their use are scarce.STUDY: We included all thiopurine-naive adults with IBD who in
ObjectivePediatric cancer patients are at increased risk for sleep disturbances; however, there are no clinical practice guidelines for treating sleep disturbances in pediatric oncology, resulting in variable approaches to sleep management across clinicians. The current study surveyed clinicians regarding their approaches to assessing and treating sleep.MethodsA total of 200 pediatric oncology cli
Several ice-dammed lakes formed between the Younger Dryas moraines and the Tana River valley during the retreat of the Fennoscandian Ice Sheet over northeast Norway. Drainage of these lakes left an indelible scar on the landscape; the Gaccetávži ravine, a feature over 10 km long and up to 120 m deep. Here, we use LiDAR-derived digital terrain models, alongside field investigations and novel remote
Influenced by climate warming and sea-level rise, seacoasts in many parts of the world are undergoing regime shifts, including increased coastal erosion in the southeastern Baltic Sea. The aim of this study is to reconstruct the depositional and erosional history of the Järve coastal scarp using sediment stratigraphy, new luminescence and radiocarbon dates, ground-penetrating radar, and LiDAR data
Nyborg, L. & Psouni, E. (2023). , 1
Color is the most obvious and easily determined soil property that can provide crucial information about soil composition. The NIX™ Pro color sensor (Nix) presents a user-friendly alternative to the traditional Munsell manual method, with reduced sensitivity to environmental and human factors. Therefore, a new method was developed to use Nix in combination with machine learning to quickly and affo
Water scarcity is a dynamic condition influenced by a variety of factors, including environmental variables but also political, economic, technological, and social variables. This research reflects the intersection of natural resources, governance, and human systems. Redefining water scarcity is a crucial factor for greater sustainable management in the face of increasing climate variability and g
OBJECTIVE: To examine temporal changes in late diagnosis of HIV (LD) among migrant and non-migrant people with HIV in Sweden 2003-2023 and to assess demographic and socioeconomic risk factors for LD in these two populations.METHODS: People with HIV diagnosed with HIV-1 in Sweden 2003-2023 were included (n = 6278). LD was defined as a first CD4+ T-cell count <350 cells/μL or an AIDS-defining event
Innate-like T cells (ILTCs) link innate immune responses with adaptive immune functions. This group includes invariant natural killer T (iNKT) cells, mucosa-associated invariant T (MAIT) cells, and γδ T cells. ILTCs detect transformed or stressed cells via non-classical antigen presentation pathways. For example, iNKT cells recognize CD1d-presented glycolipids, MAIT cells respond to MR1-presented
