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Breaking promises might be easier if one faces unexpectedly high costs for keeping them. Inspired by the ‘pledge and review’ mechanisms of the Paris Agreement, we investigate the role of cost uncertainty for both initial non-binding pledges and the subsequent voluntary provision of public goods. Without a pledge review process, we find that cost uncertainty not only leads to rather conservative pl
Astrocytes play a crucial role in the onset and progression of amyotrophic lateral sclerosis (ALS), a fatal disorder marked by the degeneration of motor neurons (MNs) in the central nervous system. Although astrocytes in ALS are known to be toxic to MNs, the pathological changes leading to their neurotoxic phenotype remain poorly understood. In this study, we generated human astrocytes from induce
The ALICE Collaboration at the CERN LHC has measured the inclusive production cross section of isolated photons at midrapidity as a function of the photon transverse momentum (pTγ), in Pb–Pb collisions in different centrality intervals, and in pp collisions, at centre-of-momentum energy per nucleon pair of sNN=5.02 TeV. The photon transverse momentum range is between 10–14 and 40–140 GeV/c, depend
This paper presents a new τ-lepton reconstruction and identification procedure at the ATLAS detector at the Large Hadron Collider, which leads to significantly improved performance in the case of physics processes where a highly boosted pair of τ-leptons is produced and one τ-lepton decays into a muon and two neutrinos (τμ), and the other decays into hadrons and one neutrino (τhad). By removing th
The pT-differential cross section of ω meson production in pp collisions at s = 13 TeV at midrapidity (|y| < 0.5) was measured with the ALICE detector at the LHC, covering an unprecedented transverse-momentum range of 1.6 < pT< 50 GeV/c. The meson is reconstructed via the ω → π+π−π0 decay channel. The results are compared with various theoretical calculations: PYTHIA8.2 with the Monash 2013 tune o
This study is part of a North West Europe (NWE) Interreg project called NWE-REGENERATIS that aims at the regeneration of past metallurgic sites and deposits through innovative circularity for raw materials. A novel geophysical methodology is developed to allow a 2D or 3D characterization of the recoverable metallic particles in terms of volume, type and grain sizes. We propose to integrate multi-m
Transplantation of human fetal ventral mesencephalic tissue in individuals with Parkinson's disease has yielded clinical benefits but also side effects, such as graft-induced dyskinesias. The open-label TransEuro trial ( NCT01898390 ) was designed to determine whether this approach could be further developed into a clinically useful treatment. Owing to poor availability of human fetal ventral mese
The Lund jet plane (LJP) is measured for the first time in tt¯ events, using 140 fb-1 of s=13 TeV pp collision data collected with the ATLAS detector at the LHC. The LJP is a two-dimensional observable of the sub-structure of hadronic jets that acts as a proxy for the kinematics of parton showers and hadron formation. The observable is constructed from charged particles and is measured for R=1.0 a
The production of neuroepithelial stem (NES) cells, a promising therapeutic candidate for neurological conditions such as stroke and spinal cord injuries, faces significant manufacturing challenges, particularly in quality control (QC). Specifically, current QC methods rely on labor-intensive manual assessments that are costly, time-consuming, and subject to operator bias, limiting scalability and
Prostaglandin E2 (PGE2) is synthesized by cyclooxygenase 2 (COX-2) in the arachidonic acid pathway. PGE2 promotes cancer initiation and progression while facilitating chronic inflammation and immunosuppression, partly through regulation of programmed death ligand 1 (PD-L1) in tumor cells and tumor-associated macrophages. PGE2 also modulates Hippo signaling, enhancing nuclear Yes-associated protein
A search for the production of top-quark pairs with the same electric charge (tt or tt¯) is presented. The analysis uses proton-proton collision data at s = 13 TeV, recorded by the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 140 fb−1. Events with two same-charge leptons and at least two b-tagged jets are selected. Neural networks are employed to define
Collective action problems emerge when individual incentives and group interests are misaligned, as in the case of climate change. Individuals involved in these problems are generally considered to have two options: contribute toward public solutions such as global warming mitigation or free ride. However, many collective action problems today involve a third option of investing in a “private solu
The paper reviews current trends and future directions for diagnostics and therapy with ionizing radiation. Recent advances in medical physics applied to radiation therapy, diagnostic radiology, nuclear medicine, MRI, and radiation safety are summarized. Today, much of the development is concentrated on providing conditions for individualized diagnostics and therapy for the patient, which requires
Spectrum arguments are purported to show that the betterness relation is not a transitive relation. This is a drastic conclusion since much normative theorizing and everyday reasoning assume that betterness is transitive. In order to avoid this conclusion, many reject a plausible view on trade-offs between quality and quantity. The rejection can take the form of a radical or a conservative rejecti
Ett radioaktivt nedfall efter ett kärnkraftshaveri kan resultera i kontamination av stora landområden. I syfte att skydda människors hälsa mot joniserande strålning kan storskalig sanering vara nödvändig. Sverige saknar nationell erfarenhet av denna typ av storskalig sanering. Det finns därmed stora osäkerheter i verkan av en sådan sanering som bl.a. är beroende av de enskilda saneringsåtgärdernas
Gaining insight into structural and compositional transformations occurring at the electrode/electrolyte interface during the operation of electrochemical systems is fundamental to understanding and, thus, optimizing their performance. Such an analysis must be performed in operando conditions, owing to the potential, electrolyte and time dependence of these transformations. Here, the use of X-ray
