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The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. Here we leveraged aptamer-based proteomics (>4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations (C9orf72, GRN and MAPT) compared with 3
The cerebellum is a large brain structure. Most of the mass and volume of the cerebellum is made up by the cerebellar cortex. The outer layer of the cerebellar cortex is divided functionally into long, thin strips called microzones. We argue that the cerebellar microzone computation is the aggregate of simple unit computations and a passive effect of anatomy, unaided and unlearned, which we recrea
The Paris Agreement of the United Nations Framework Convention on Climate Change is a binding international treaty signed by 196 nations to limit their greenhouse gas emissions through ever-reducing Nationally Determined Contributions and a system of 5-yearly Global Stocktakes in an Enhanced Transparency Framework. To support this process, the European Commission initiated the design and developme
Advances in Earth observation capabilities mean that there is now a multitude of spatially resolved data sets available that can support the quantification of water and carbon pools and fluxes at the land surface. However, such quantification ideally requires efficient synergistic exploitation of those data, which in turn requires carbon and water land-surface models with the capability to simulta
Current models for understanding the spatial diffusion of innovation exhibit significant limitations when it comes to explaining how transformative innovations in sectors of the foundational economy travel between cities and countries. Transformative innovations in infrastructure sectors like water, energy, or waste management are typically not reducible to single products or technologies but rely
Surface-subsurface flow models for hydrological applications solve a coupled multiphysics problem. This usually consists of some form of the Richards and shallow water equations. A typical setup couples these two nonlinear partial differential equations in a partitioned approach via boundary conditions. Full interaction between the subsolvers is ensured by an iterative coupling procedure. This can
The atmosphere, ocean, and sea ice components in Earth system models are coupled via boundary conditions at the sea surface. Standard coupling algorithms correspond to the first step of an iteration, so-called Schwarz waveform relaxation. Not iterating is computationally cheap but introduces a numerical coupling error, which we aim to quantify for the case of a coupled single column model: the EC-
Det finns ett växande intresse för den roll som lokala aktörer spelar i utformningen av regionala utvecklingsbanor i mindre, perifera regioner. Men, när de strukturella förutsättningarna är begränsade eller ogynnsamma begränsas dock möjligheterna för lokala aktörer. I denna artikel kombinerar vi begreppen agens och möjlighetsutrymme med en processmodell för adaptiva cykler för att identifiera när,There is a growing interest in the role of agency in shaping regional development paths in smaller, peripheral regions. However, when structural pre-conditions are limited or unfavourable, opportunities for local actors are constrained. In this paper, we combine the concepts of agency and opportunity space with a process-model of adaptive cycles in order to identify when, how, and why local actors
Before curation, there is collection. Before visitors engage with objects in an exhibition, collection managers engage with the objects and, in some cases, also the donors. It makes sense that especially when difficult pasts are involved, collection managers have affective encounters with the materiality before visitors do. So why has the affective turn focused mainly on engaging visitors’ emotion
Hybrid zones present a unique framework to study the genetic basis of reproductive isolation and speciation. The European fire-bellied toad (Bombina bombina) and yellow-bellied toad (B. variegata) hybridize in a zone across several thousand kilometres in Central Europe. The Bombina system has been examined for more than a century and its scientific legacy comprises the development of the ultilocus
Disenchantment, reenchantment: Changing interpretations of visions and visionaries in early modern SwedenI analyse the changing interpretations of visions and visionaries in Sweden between the sixteenth and early nineteenth centuries, arguing that before 1700 they were primarily viewed in terms of a demonological discourse, although a more positive interest was also evident among the peasantry and
BackgroundThe lack of effective screening methods for the detection of ovarian cancer leads to late diagnosis and poor outcomes. High-grade serous ovarian carcinoma (HGSC) is strongly dominated by copy number alterations (CNAs), resulting from underlying mutational processes. Several studies have reported the detection of ovarian carcinoma-derived somatic mutations in cervical samples, uterine lav
An outpouring of scholarly editions: Media history perspectives on the editing of historical sources in Sweden, 1834–1847This article examines the scholarly editing of historical sources for publication in nineteenth-century Sweden. The analysis focuses on the approximately 500 letters exchanged between Hans Järta, the Director General of the National Archives of Sweden, and Bror Emil Hildebrand,
Songbird migration involves frequent migratory flights interrupted by several days of stopover to refuel. For first-year migratory birds, this entails stopping in unfamiliar locations to exploit local resources and maximise fuelling rates. However, stopovers also pose mortality risks due to predator presence. We aimed to determine whether auditory cues from avian predators with differing hunting s
Quantum information science has leaped forward with the exploration of high-dimensional quantum systems, offering greater potential than traditional qubits in quantum communication and quantum computing. To advance the field of high-dimensional quantum technology, a significant effort is underway to progressively enhance the entanglement dimension between two particles. An alternative effective st
