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In Parkinson’s disease, there is an accumulation of α-synuclein (SYN) aggregates in neurons, which is promoted by neuroinflammation. In neural cells, cytokine-induced SYN aggregation is modulated by heparan sulfate (HS) derived from glypican-1 (GPC1) by amyloid precursor protein (APP) and nitric oxide (NO)-dependent cleavage. We have explored possible interplay between APP, GPC1, and SYN in undiff
Background: Green environments have been shown to be important for health, although less is known about what, in the environment and the individual, leads to interaction and promotes engagement in activities. Aim: To explore some individuals’ perceptions of their green neighbourhood environment and how the interaction with it promotes engagement in activities. Material and methods: A qualitative a
INTRODUCTION: Plasma tau phosphorylated at threonine 217 (P-tau217) and neurofilament light (NfL) have emerged as markers of Alzheimer's disease (AD) pathology. Few studies have examined the role of sex in plasma biomarkers in sporadic AD, yielding mixed findings, and none in autosomal dominant AD. METHODS: We examined the effects of sex and age on plasma P-tau217 and NfL, and their association wi
The interatomic Auger effect following O 1s ionization in N2O has been experimentally investigated using multi-electron coincidence spectroscopy. The expected transition energies have been established by comparison to the measured N 1s−1v−1 core-valence double ionization energies. We describe a procedure to eliminate the background of two competing processes contributing spectroscopic signatures t
Given a disproportionate scholarly focus on a high-profile litigation on manual scavenging–the manual cleaning of human faeces–in India, this paper aims to explore the experiences of NGOs led by Dalits–formerly “untouchables”–in navigating the judiciary to eradicate manual scavenging. It does so by first exploring the frequency and characteristics of court cases on manual scavenging, and second by
STUDY QUESTION: Which substances and signal transduction pathways are potentially active downstream to the effect of FSH and LH in the regulation of human oocyte maturation in vivo? SUMMARY ANSWER: The regulation of human oocyte maturation appears to be a multifactorial process in which several different signal transduction pathways are active. WHAT IS KNOWN ALREADY: Many studies in animal species
On-demand droplet generation from a continuously flowing stream of aqueous phase has profound applications in dropletbased microfluidics for rare event encapsulation studies. Here, we present acoustic relocation-based droplet generation from co-flowing immiscible fluids in an on-demand manner using bulk acoustic wave (BAW). After on-demand droplet generation, droplets are isolated using the same a
Objectives: To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data. Methods: All people aged ≥18 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome
The United Nations Sustainable Development Goals (SDGs) include social and ecological goals for humanity. Navigating towards reaching the goals requires the systematic inclusion of perspectives from a diversity of voices. Yet, the development of global sustainability pathways often lacks perspectives from the Global South. To help fill this gap, this paper introduces a participatory approach for v
Reactive oxygen species (ROS) are implicated in epithelial cell-state transition and deposition of extracellular matrix upon airway injury. Of the many cellular targets of ROS, oxidative DNA modification is a major driving signal. However, the role of oxidative DNA damage in modulation profibrotic processes has not been fully delineated. Herein, we report that oxidative DNA base lesions, 8-oxoG, c
Cover crops (CCs) can improve soil nutrient retention and crop production while providing climate change mitigation co-benefits. However, quantifying these ecosystem services across global agricultural lands remains inadequate. Here, we assess how the use of herbaceous CCs with and without biological nitrogen (N) fixation affects agricultural soil carbon stocks, N leaching, and crop yields, using
This final report accounts for the framework and key results from the VINNOVA-funded research and development project, Building Innovation Capacity. The purpose of the BIC project was to explore two features of innovation capacity: 1. How do we explain and measure innovation capacity? 2. How do we develop innovation capacity? Overall, the BIC project shows that an organization's innovation ability
OBJECTIVE Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to T2D, insulin resistance (IR), and insulin secretion (IS) aggravate these associations. RESEARCH DESIGN AND METHODS We used data from two population-based Scandinavian studies with case subjects
In the middle of the COVID-19 pandemic, several development activities were undertaken in a Swedish and a Danish organization. The research project focused on how the organizations’ innovation ability was affected by a developed Nordic inspired learning model. It was found that the tested organizational learning model holds great promise for the improvement of organizations capability to innovate,
Background: Amplification of 1q (amp(1q); ≥4 1q copies) has repeatedly been reported to predict a worse outcome in multiple myeloma (MM), whereas the impact of gain of 1q (gain(1q); three 1q copies) is less clear. Methods: We investigated survival of MM in relation to amp(1q) and gain(1q) by retrospectively analysing 346 consecutively newly diagnosed MM (NDMM) patients. Of these, 62 (18%) had amp(
Renovations of the housing rental stock have become a political concern since they have been claimed to drive gentrification and affect tenants’ everyday lives as well as long-term housing conditions. Furthermore, new actors have entered the market, partly as a result of high supply on the international capital markets creating a flow of capital into market segments. This has led to a critique of
Bronchial and alveolar remodeling and impaired epithelial function are characteristics of chronic respiratory diseases. In these patients, an increased number of mast cells (MCs) positive for serine proteases, tryptase and chymase, infiltrate the epithelium and alveolar parenchyma. However, little is known regarding the implication of intraepithelial MCs on the local environment, such as epithelia
The formation and evolution of galaxies have proved sensitive to the inclusion of stellar feedback, which is therefore crucial to any successful galaxy model. We present INFERNO, a new model for hydrodynamic simulations of galaxies, which incorporates resolved stellar objects with star-by-star calculations of when and where the injection of enriched material, momentum, and energy takes place. INFE
The increasing use of timber structures worldwide has brought attention to the challenges posed by their lightweight nature, making them more prone to vibrations than more massive structures. Consequently, significant research efforts have been dedicated to understanding and mitigating vibrations in timber structures, while scientific committees strive to establish suitable design regulations. Thi
The novel wave-shaped bowl piston geometry design with protrusions has been proved in previous studies to enhance late-cycle mixing and therefore significantly reduce soot emissions and increase engine thermodynamic efficiency. The wave-shaped piston is characterized by the introduction of evenly spaced protrusions around the inner wall of the bowl, with a matching number with the number of inject
