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A novel phylogenetic hypothesis for the subfamilies Dyopsinae and Thiacidinae is presented. For the first time, the type genus and species of Thiacidinae, Thiacidas postica Walker, is sequenced and analysed within an expanded dataset that includes a diverse array of representative Noctuidae. Utilizing a combination of phylogenomic data and traditional phylogenetic analyses based on legacy (Sanger)
To estimate prevalence and associated factors of comorbid fibromyalgia in axial spondyloarthritis (axSpA), and to explore discriminative capacity (for discerning fibromyalgia) of algometry-assessed pain sensitivity measures. AxSpA patients from the population-based SPARTAKUS cohort evaluated for fibromyalgia (1990 ACR criteria) were included (n = 243; r-axSpA/nr-axSpA = 165/78). Factors associated
In 2024–2025, the Cystic Fibrosis Foundation (US) and Cystic Fibrosis Trust (UK) hosted an International CFRD Consortium round-table webinar series for basic science, translational, and clinical researchers with the goal of sharpening mechanistic understanding of CFRD pathogenesis and prioritizing therapeutic development. This review summarizes the research priorities identified in the Internation
Snow flies ( Chionea ) are wingless crane flies uniquely adapted to extreme cold environments. Adults remain active throughout winter and move rapidly across the snow, even at temperatures below freezing. To investigate the molecular adaptations that make this possible, we sequenced and annotated the genome of Chionea alexandriana and compared it with related species and with the cold-adapted midg
Neurodegenerative diseases have traditionally been defined in vivo based on clinical symptoms. However, the development of biomarkers has enabled a shift towards in vivo biological definitions. There is now a need to characterize memory clinic populations using multi-dimensional biomarker information. Here, we employed a data-driven approach to develop a biological framework for categorizing indiv
This paper addresses the hybrid quantized signal detection problem in a distributed radar system, where widely separated antennas transmit low-bit quantized data with varying quantization levels depending on the different bandwidth constraint for each channel to a fusion center. To enable a high detection performance with such hybrid quantized data, we formulate the generalized likelihood ratio, R
Attosecond photoelectron spectroscopy has opened up for studying light–matter interaction on ultrafast time scales. It is often performed with interferometric experimental setups that require outstanding stability. We demonstrate and characterize in detail an actively stabilized, versatile, high spectral resolution attosecond beamline based on a Mach-Zehnder interferometer. The active stabilizatio
We present a high-repetition rate, atttosecond light source, emitting controlled short trains of attosecond pulses. We apply this source to the study of photoionization of atoms using a 3D photoelectron/ion coincidence spectrometer.
This Massive Open Online Course (MOOC), offered in partnership with online learning provider Coursera, is a free resource for university students who are currently involved in writing assignments or degree projects as well as for students who wish to learn about academic writing in order to prepare for future writing tasks at university. Although the course provides guidance to all student writers
Background: The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action. Methods: Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate-severe disease activity were random
Background and PurposeIn a previous study comparing the amount of visual field damage at presentation in patients having open-angle glaucoma (OAG) identified through screening and in patients diagnosed in routine clinical practice in the 1990s, the damage was considerably worse in the clinically diagnosed patients. In the present study we compare visual field damage at presentation in the same 402
In South Africa, the family Heliozelidae in the order Lepidoptera is restricted to four known species. The grapevine leaf miner, Holocacista capensis, feeds between the epidermal layers of a grapevine leaf, predominantly along the leaf margin. A final instar larva will descend from the blotch mine/gallery to attach its cocoon casing (constructed from the epidermal layers of the mined gallery) to a
Children with cancer experience fragmented school attendance during treatment. Telepresence robots that connect them with school during treatment periods were explored through an intervention involving participant observation followed by semi-structured interviews from 2020–22 with children with cancer, their class teachers, and classmates. We used an abductive approach, inspired by the Agential R
Background: Insulin resistance (IR) is associated with cardiovascular disease (CVD). However, insulin immunoassay variability and scarce research of the elderly have hindered the adoption of IR assessment for CVD prevention. We asked whether the probability of having IR [p(IR)]—derived from insulin and C-peptide mass-spectrometry assays—was associated with CVD in the elderly. Methods: A random coh
