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Despite advances in understanding the mechanisms, risk factors and treatment strategies for Alzheimer’s disease (AD), no approved therapies exist to prevent or delay onset in at-risk individuals or those with elevated biomarkers who do not yet show symptoms. Multiple candidate interventions are now being evaluated in clinical trials in these settings, raising key questions around which populations
Purpose: Ocular coherence tomography (OCT) biomarkers have previously been able to predict low visual acuity (VA). The purpose of this study was to identify other OCT predictors for a final VA ≤35 and risk factors for macular atrophy (MA) in eyes with neovascular age-related macular degeneration (nAMD). Methods: This retrospective observational study included 107 treatment naïve nAMD eyes who init
Effective disaster risk management in today's evolving risk landscape necessitates functional collaboration between land use planners and preparedness actors, such as fire and rescue services and crisis management organisations. This study investigates barriers and enablers to such collaboration through a combined exploratory scoping study and empirical survey conducted in Sweden, revealing both c
Although there has been a considerable increase in the understanding of glioblastoma and investigations into the therapeutic utility of several novel putative active compounds, the prognosis of glioblastoma patients remains dismal. This paradox makes glioblastoma a unique disease, in which the availability of key molecular and biological insight does not translate into therapeutic discovery or imp
Background: Mistletoe extract is a widespread complementary therapy mainly used for quality-of-life improvement in cancer patients. Advanced pancreatic cancer is associated with poor quality of life and better therapies for symptomatic relief are highly needed. Aim: MISTRAL aimed to assess the impact of mistletoe extract on quality of life, body weight, observed costs and blood biomarkers in patie
Background: Repetitive elements, particularly satellite DNA (satDNA), play a significant role in genome evolution and organisation. However, their diversity and evolutionary dynamics remain poorly understood in non-model organisms. Freshwater crayfish (Decapoda, Astacidea) have large genomes with a high chromosome number and are rich in satDNAs. This makes them attractive for studying the impact o
Eutrophication and global warming are key drivers of oxygen loss, also termed deoxygenation, in coastal ecosystems worldwide. Artificial reoxygenation has been suggested as a local or regional solution to increase oxygen concentrations and improve water quality by various parties, including water managers and industry. Three main approaches have been proposed: (1) bubbling with air with the aim to
Background: Primary tumor volume (GTVp) is a key prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC) treated with radiotherapy. We aimed to externally validate this association and assess its relevance in other head and neck sites. Methods: Patients from the RADCURE dataset were analyzed using Cox regression for local failure, progression-free survival (PFS), and overall survival (O
This paper presents a pipeline which uses a multiatlas approach for multiorgan segmentation in whole-body CT images. In order to obtain accurate registrations between the target and the atlas images, we develop an adapted feature-based method which uses organ-specific features. These features are learnt during an offline preprocessing step, and thus, the algorithm still benefits from the speed of
Summary: Existing approaches to modelling antibody concentration data are mostly based on finite mixture models that rely on the assumption that individuals can be divided into 2 distinct groups: seronegative and seropositive. Here, we challenge this dichotomous modelling assumption and propose a latent variable modelling framework in which the immune status of each individual is represented along
Virtual Imaging Trials (VITs) provide a reproducible, cost-effective, and ethical approach for testing medical imaging technologies. In breast imaging, realistic phantoms across density levels are crucial, as density affects cancer risk assessment and imaging performance. We have previously demonstrated the use of Perlin noise to simulate breast parenchyma. This study establishes a systematic mapp
Bismuth-based compounds, such as Bi1-xSbx or Bi2Te3, have outstanding electronic properties especially for advanced quantum devices. However, the potential of low-dimensional group V-Bi materials is largely undetermined. Here, we report the experimental realization of a two-dimensional (2D) BiAs layer with giant Rashba spin splitting, grown on an InAs(111)B substrate via molecular beam epitaxy. AR
Den här uppsatsen undersöker hur värdeladdade ord som relaterar till sexuell läggning, etnicitet och social klass har översatts från engelska till svenska respektive danske genom tiderna och om det finns skillnader mellan språken. Texterna som ligger till grund för undersökningen är Jack Kerouacs On the Road (1957) och On the Road – The Original Scroll (2007) samt deras svenska och danska översätt
I denna magisteruppsats undersöks hur de intertextuella elementen i romanen Shadow of night av Deborah Harkness kan översättas till svenska på ett sätt som bevarar den funktion som intertextualiteten har i originaltexten. Inom ramen för magisterarbetet har romanens första kapitel översatts, och i uppsatsen analyseras denna översättning kvalitativt med hjälp av tre utvalda textpassager som belyser
This study examines how gender is performed and how the norm of the “ideal nurse” is constructed within psychiatric care in Sweden. Operating at the intersection of historical care ideals and New Public Management (NPM), the nursing profession faces structural tensions between professional autonomy and organizational subjection. Drawing on feminist organizational sociology, Joan Acker’s theory of
Urban water systems in southern Sweden face increasing pressure from both short- duration intense rainfall, which can cause pluvial flooding and pollutant discharges, and more frequent dry periods, which motivate water reuse (IPCC 2023; Schimanke et al. 2022; Canedo Rosso et al. 2025). Rainwater harvesting (RWH) tanks can contribute to both goals (Campisano et al. 2017), but their detention benefi
This Development Dissertation Brief summarises a study of Sweden’s long-term media aid engagement in Vietnam from 1993 to 2007, examining howjournalistic skills, norms and practices were introduced, translated and reshapedwithin an authoritarian media system. Drawing on project documentation andinterviews with Swedish journalism trainers and radio technicians, the disserta-tion analyses how techno
Public Law in a Hybrid State presents a broad sociological analysis of legal developments in contemporary Uzbekistan, using this example to assess why states with some authoritarian features may promote legal reforms and why the modernization of legal institutions may generate benefits for governments. It examines how, alongside constitutional changes, reforms in administrative law play an importa
Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may cause stress-induced transient acute cardiac dysfunction through myocardial stunning, in the form of exacerbation-triggered Takotsubo syndrome (referred to as Takotsubo stunning). Although prior studies suggest an association between AECOPD and transient cardiac dysfunction, existing evidence is limited to retro
