Filtyp
FLT3 is a critical prognostic marker in acute myeloid leukemia (AML) due to its high frequency of mutation. Primary mutations in FLT3 include point mutations or deletions in the tyrosine kinase domain (TKD) and internal tandem duplications (ITD) in the juxtamembrane (JM) region. These mutations lead to ligand-independent activation, disrupting the JM region and kinase domain interaction, resulting
Homelessness has increased significantly in Sweden since the early 1990s. A national survey of homelessness in 2023 showed that 27,383 people were in one of the four homelessness situations that are used in Sweden, namely 1) Acute homelessness, 2) Institutional and supported housing, 3) Long-term housing organised by the municipality and 4) Short-term accommodation arranged on one’s own. These homHomelessness has increased significantly in Sweden since the early 1990s. A national surveyof homelessness in 2023 showed that 27,383 people were in one of the four homelessnesssituations that are recognised in Sweden, namely: (a) acute homelessness; (b) institutional orsupported housing; (c) long-term housing organised by a municipality; and (d) short-termaccommodation arranged by people themselv
FN:s oberoende kommission har slagit fast att ett folkmord pågår i Gaza. Trots det vägrar Lunds universitetsledning att ompröva sina samarbeten med israeliska universitet och företag med kopplingar till vapenindustrin.Lunds universitet måste nu ta ansvar och avbryta dessa samarbeten – eller erkänna att man väljer att blunda för brott mot mänskligheten. Det skriver 16 forskare från Lunds universite
Polyoxometalates (POMs) and their instrinsic discrete nature has enabled them to support a wide range of research spanning solution-speciation chemistry, biological/medical assays, catalytic processes and fundamental crystallography. The structure-property relationship of POMs are a consequence of their constiuent metal atoms, which inevitably are formed under specific regimes - for simplicity, ac
Circularity metrics simplify complex systems, and trade-offs between simplicity, scope, and usability introduce unavoidable limitations. We revisit the Ellen MacArthur Foundation’s Material Circularity Indicator (MCI) to identify opportunities for a more accurate, comprehensive, reliable measure of circularity. Although widely used and highly regarded, the MCI exhibits limitations and methodologic
INTRODUCTION: While the characteristics and medical management of patients treated with long-term oxygen therapy (LTOT) have transformed during the last decades, the evidence base for LTOT itself remains largely unchanged. This study aimed to compare the risk of hospitalization and death among hypoxemic patients discontinuing LTOT, with that of controls continuing therapy.METHODS: This was a retro
Glucuronidation is the major phase II biotransformation reaction that facilitates the clearance of exogenous compounds from the human body. Glucuronidated metabolites have been investigated in urine samples at a broad scale; however, their characterization in other human biospecimens is underexplored. Our study has now performed a comprehensive profiling of glucuronides in plasma, fecal, and cereb
Background: Peritoneal recurrence (PREC) following nephrectomy for localized renal cancer (RCC) is rare. Our objective was to report a multicenter analysis of PREC to analyze incidence, treatment, survival and risk factors. Methods: Between 1987 and 2023, patients with PREC following radical or partial nephrectomy (PN) for localized RCC across ten European institutions (UroCCR, NKI, IRCCS, Foch an
Speaking in poor acoustic conditions constitutes a risk factor for voice disorders. This study investigated how speaker’s comfort and vocal effort were affected during short speech tasks in four different room acoustic configurations. Voice recordings of the speech tasks and self-evaluations of the speaker’s comfort were collected from 15 participants in four room acoustic configurations as part o
Scope: Vascular graft or endograft infection (VGEI) is a severe complication requiring a multidisciplinary approach combining surgery and antimicrobial therapy. This study aimed to develop expert consensus on the management and follow-up of VGEI, with a focus on antimicrobial strategies. Methods: A modified Delphi method was conducted to reach consensus on key aspects of VGEI care, including antim
Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, human cell-type-specific transcriptomic aging clocks are developed using high-quality single-nucleus RNA sequencing data from post mortem human prefrontal cortex tissue of 31 donors aged 18–94 years, encompassing 73,941 high-quality nuclei. Di
Tuning the spectral and directional characteristics of thermal emission is critical for advancing technologies such as thermophotovoltaics (TPVs), passive thermal radiative cooling (PTRC), and solar thermophotovoltaics (STPVs), yet scalable fabrication methods remain limited. Here, femtosecond laser surface processing (FLSP), a top-down ablation and re-solidification approach is employed, to creat
This paper presents a single-layer filtering antenna (filtenna) based on a compact square substrate-integrated waveguide (SIW) cavity for millimeter-wave (mmWave) applications. The cavity operates in the fundamental TE110 mode to enable beam scanning, while a central shorting via introduces the TE210 mode, broadening the bandwidth. A radiating slot, placed at high-intensity regions of both modes,
BACKGROUND: Respiratory viruses, such as influenza viruses and SARS-CoV-2, cause severe infections of the respiratory system. Cohort studies and clinical observations indicate that patients with severe influenza A virus (IAV) infections are at an increased risk of developing an ischemic stroke event. However, the underlying mechanisms remain elusive. To this end, we investigated the consequences o
Abstract: The breast cancer long-term survival rate has improved; early detection of local recurrence and second primary cancers has been crucial to this success. Mammography is the standard imaging technique for follow-up, but its sensitivity is affected by breast density and post-treatment changes. This article discusses the role of mammography in the follow-up of women after breast cancer treat
Debattartikel: Forskningen krockar allt oftare med politiken. Sveriges forskare varnar nu för utvecklingen. Och deras oro är befogad.
The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important but structurally elusive intrinsically disordered protein. In this study, we investigate the conformational ensemble of a 35-residue AICD segment encompassing the conserved YENPTY motif using molecular
