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Importance Even within individuals who are amyloid positive, clinical symptoms can be impacted by Alzheimer pathology, other pathologic proteins, and cognitive reserve or resilience. Understanding how each of these factors contributes to a patient’s clinical presentation is crucial for prognosis and treatment decisions in the era of disease-modifying therapies. Objective To evaluate tau-clinical m
Building resilient and sustainable energy systems is a critical challenge for disaster-prone regions in the Global South. This study investigates the energy management of a networked microgrid (NMG) system on Lombok Island, Indonesia, a region frequently exposed to natural disasters (NDs) and characterized by vulnerable grid infrastructure. A multi-objective optimization framework is developed to
Sustainability has received increasing attention in recent years, particularly surrounding concerns of poverty in the Global South, the climate emergency, the loss of biodiversity, and the COVID-19 pandemic. Competition and public authorities are more frequently encountering sustainability questions, while states are more generally called upon to foster sustainability by the UN Resolution 70/1. Ag
It remains unclear how transformative innovation policies can be implemented across various regional contexts. Through policy review, interviews and focus group interviews with key actors, this paper investigates industrial regions’ design and implementation of transformative innovation policies in three Nordic countries. We find that the characteristics of the regional innovation system, unique t
Gastrointestinal (GI) interventional endoscopy has evolved into a cornerstone of modern gastroenterology, offering minimally invasive solutions for complex conditions. However, these procedures are not without risk, particularly with respect to post-procedural infections. While rare, such infections can have significant clinical consequences and are increasingly recognized as a public health conce
A biorefinery can operate with various plant materials as feed stock, (in contrast to fossil-based oil refineries). It has been defined by the International Energy Agency, Task 42, as “the sustainable processing of biomass into a spectrum of marketable bio-based products (chemicals, materials) and bioenergy (biofuels, power, heat)”. One of the challenges in operating large-scale facilities is that
Human papillomavirus (HPV) vaccination may eventually eradicate oncogenic vaccine-targeted HPVs but only with a strategy that also protects unvaccinated individuals. We compared the impact of gender-neutral and girls-only vaccination strategies on the indirect and direct protection of unvaccinated and vaccinated young women against HPV16/18 infection using HPV16/18 seropositivity and PCR positivit
Laila Lalami’s novel The Moor’s Account reclaims the erased historical voice of the Moorish slave Estebanico, one of the first Arab Africans on the American continent in the 1500s. While Lalami explicitly positions her novel as a postcolonial revision of Cabeza de Vaca’s colonial report on the fate of Estebanico, this essay argues that a significant part of the novel’s literary resistance to Arab
This article presents a theoretical framework for deriving simple analytical expressions for spurs resulting from second and third order nonlinearities in fractional-N phase locked loops (PLL). Furthermore, a previously proposed linearization technique where several sigma-delta modulators (SDMs) operate in parallel with relative time offsets between them, is further analyzed using the periodic non
PurposeWelfare technology (WT) intends to promote engagement in everyday activities and the well-being of older adults at risk of developing or already having impairments. However, its effectiveness depends on how older adults experience and interact with WT. In this study, we aimed to investigate the relationship between various forms of WT user experience (perceived usability, perceived control,
The new year in Sweden began with some record-breaking cold temperatures. Temperatures in the village of Kvikkjokk in the northern Swedish part of Lapland dropped to -43.6°C, the lowest recorded since records began in 1887.Yet for the majority of Swedish households, heating is not an issue. Those living in the multi-household apartment blocks that characterise Sweden’s towns and cities enjoy avera
With the urgent need to address climate change, it is critical to confront fossil fuel dependency, particularly in the Global North. This requires confronting the spatio-cultural dimensions of fossil fuels, including how they have become embedded in those locations most closely tied to the fossil fuel industry. This article integrates insights from energy geographies with Hein's concept of petrole
This thesis studies reproducing kernels that are realized as pointwise quotients of two other kernels, including far-reaching generalizations of de Branges–Rovnyak spaces. In the first article, we study reproducing kernels arisingfrom the well-known multiplier criterion. They are intimately connected to certain operator inequalities, such asthe famous inequality of Shimorin in sub-Bergman spaces,
Despite a wealth of sophisticated CFD-methods, most designs are still based on one-dimensional and two-dimensional inviscid analytical tools. In such methods, realistic loss and angle assessment are indeed critical in order to arrive at correct loading, flow coefficient and reaction. The selected values are normally retained through the detailed design sequence for each iteration. This means that
With a significant impact on turbomachinery blade performance, surface curvature distribution becomes one of the essential factors in the design of high-efficiency blades. This study focuses on applying computational fluid dynamics (CFD) to evaluate turbine rotor blade performance. The main aim is to analyze the influence of incidence and geometry shape on the performance of a gas-turbine blade in
In this work, numerical analysis was performed to predict the behaviour of high Reynolds number turbulent cross-flows used in film cooling applications. The geometry included one row of three discrete coolant holes inclined at 30 degrees to the main flow. In the computational model, the width of the channel was cut into one sixth and symmetry boundaries were applied in the centreline of the coolan
A numerical and experimental study of partial admission in a low reaction two-stage axial air test turbine is performed in this paper. In order to model one part load configuration, corresponding to zero flow in one of the admission arcs, the inlet was blocked at one segmental arc, at the leading edge of the first stage guide vanes. Due to the unsymmetrical geometry, the full annulus of the turbin
In this paper, the effects of axial gap distance between the first stage stator and rotor blades and multiblocking on aerodynamics and performance of partial admission turbines are analyzed numerically. The selected test case is a two stage axial steam turbine with low reaction blades operating with compressed air. The multiblocking effect is studied by blocking the inlet annulus of the turbine in
