Filtyp
Both high-mountain rivers and wet-based mountain glaciers are considered effective erosion agents. They acted alternatively or simultaneously during the late Quaternary in the Tatra Mountains (West Carpathians) thus producing a vast amount of clastic material that was subject to deposition, reworking and transportation downstream. A small fraction of that amount of the material is still preserved
Seagrass meadows are recognized for their coastal protection services in terms of reducing the wave runup level and limiting coastal erosion. This study aims to quantify these services for a dense seagrass meadow located in a non-tidal, fetch-limited sea. A year-long field campaign was conducted to collect data on wave statistics along the cross-shore direction of the seagrass meadow, bathymetry,
BACKGROUND: Alterations in ribosomal DNA copy number (rDNA-CN) and global DNA methylation have been associated with genomic instability and various diseases. However, their relevance in myocardial infarction (MI) has not been fully investigated.METHODS: We measured rDNA-CN and global DNA methylation in blood samples from MI patients ( n = 100) and healthy controls ( n = 109) using Droplet Digit
Human calcitonin (hCT) is a peptide hormone with therapeutic potential for bone-related disorders, yet its clinical application is hindered by a strong propensity to form amyloid fibrils. Strategies that effectively suppress hCT aggregation are therefore essential for enabling its reintroduction into pharmaceutical development. In our previous work, heme emerged as a potent inhibitor of hCT fibril
We present the structural and functional characterization of a single-stranded DNA-binding protein (SSB-M5) identified from a hot spring metagenome in Vatnajökull National Park, Iceland. This small protein (136 aa; 15,695 Da) shares 100% amino acid sequence identity with two previously uncharacterized SSBs from hyperthermophilic Fervidobacterium species. Functional complementation assay demonstrat
Interactions between amyloidogenic proteins are emerging as critical drivers of neurodegenerative diseases. Among others, in Alzheimer’s disease (AD) and severe forms of chronic traumatic encephalopathy (CTE), codeposition of tau and amyloid-β (Aβ) leads to worsening of clinical outcomes and disease progression. Despite the importance of such heterotypic interactions, the underlying molecular mech
BACKGROUND: Long COVID has emerged as a global health challenge, with increasing evidence of cardiovascular sequelae. Most previous studies have focused on hospitalised cohorts, whereas cardiovascular risk in community-managed long COVID cases remains less explored. We aimed to investigate the incidence of major cardiovascular events in individuals with long COVID compared to those without long CO
Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS. T
This short documentary film narrates the socio-environmental conflict triggered by a large-scale copper mining project aimed at extracting critical minerals for the global Energy Transition from the heart of the Andean Amazon. Through Theatre of the Oppressed and the voice of Soraida Chindoy Buesaquillo, indigenous territorial defender, the film narrates the process of the Tent of Resistance in P
This article explores the potential of full-count historical census microdata to enhance our understanding of occupational activity and retirement among older men and women in Sweden between 1880 and 1910 – a period preceding the introduction of a universal pension system. Drawing on the SwedPop infrastructure, we examine how occupational information was recorded, coded, and interpreted in the Swe
BACKGROUND: The aim was to improve the realism of patient models for Monte-Carlo based evaluation of image-based quantification of tumour volume and activity in [68Ga]Ga-DOTA-TOC PET and [177Lu]Lu-DOTA-TATE SPECT images.METHODS: Three phantoms from the XCAT population were used as basis. Tumour structures were obtained from segmentation of patient 68Ga-PET images and positioned at relevant positio
The article examines Starbucks as a global cultural symbol whose success varies sharply across contexts, contrasting its exceptional growth in South Korea with its near failure in Sweden. In Korea, Starbucks has thrived by pioneering localized marketing and spatial design strategies, enjoying unusual autonomy from headquarters and shaping new consumption patterns; however, recent controversies hav
Short overview over possibilities top use archives of artistich research within film studies, in ordert to study uncompleted works
The collagen triple helix assembles hierarchically into bundled oligomers, solvated networks, and fibers. Synthetic peptide assemblies, driven by supramolecular interactions, can form single triple helices through intrahelical amino acid pairs; however, the principles guiding interhelical associations into higher-order structures remain unclear. Here, we incorporate cation−π and electrostatic char
In the fast-evolving arena of climate finance, equitable access to and allocation of funds for adaptation continue to pose a significant and urgent challenge. In theory, to prepare for the impacts of climate change in an equitable way, regional, national, and European Union (EU) funding tenders on climate adaptation should prioritize the most climate-vulnerable local administrations. However, evid
Packaging-free grocery shopping enables consumers to avoid single-use packaging and buy specific quantities tailored to their needs. Despite its benefits, it faces challenges such as limited product variety and availability. This qualitative study explores the motivations, behaviors, and strategies of individuals who engage in or discontinue packaging-free shopping, including how they combine pack
