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SREBP transcription factors are key regulators of lipid metabolism and play a central role in metabolic dysfunction-associated steatotic liver disease (MASLD). In a recent issue of Molecular Cell, Nie et al. 1 have discovered that Drosha, known for microRNA processing, regulates the maturation and activation of SREBP1 in the liver, and this seems to be important in MASLD.
The dominant narrative on equity, diversity, and inclusion in U.S. medical research emphasises the underrepresentation of Black and Hispanic participants in clinical trials, largely based on therapeutic phase 2 and 3 trials. Far less attention has been paid to phase 1 trials—particularly those involving healthy volunteers who assume health risks without therapeutic benefit, often for money. Focusi
Challengers struggle against more powerful elites and authorities to resolve environmental problems driven by social forces, but can sustainability research contribute to such collective action while remaining scientific? After five years of movement-relevant sustainability research using Burawoy’s extended case method, I seek to make three contributions. Empirically, I present strategic alliances
Reflective practice serves as an important mechanism for developinginterpersonal skills in communication training. This paperreports on an online chat-based exercise conducted ata university in Sweden since 2021 as part of social work communicationtraining. The exercise responds to a growing demand fordigital communication training for future social workers and aims tostimulate students’ reflectio
Most flowering plants depend on insect pollinators for their reproduction, yet these pollinators have been facing considerable losses in abundance and diversity in recent decades. The ongoing pollinator declines, caused by stressors including land-use and climate change, have raised concerns for species-rich plant communities such as those found in semi-natural grasslands. These communities contai
Objective. High-frequency oscillations (HFOs) are a potential biomarker of the epileptogenic zone (EZ) in patients with focal epilepsy. Previous research has estimated that HFOs arise from regions as small as a single cortical column (1 mm3), making events difficult to detect with the coarse spatial sampling of clinical-standard electrocorticographic (ECoG) arrays. We tested whether high-resolutio
Glycobiology has undergone a profound conceptual transformation from a largely descriptive discipline to a central framework for understanding biological regulation in health and disease [...].
Understanding migration strategies in closely related species is essential to assess population-specific threats and to identify the ecological drivers of speciation. To compare migration strategies and environmental conditions across the annual cycle, we tracked Western Black-eared Wheatears, Eastern Black-eared Wheatears and Pied Wheatears. Individual migration routes were reconstructed from mul
Background: Win statistics offer an alternative approach to clinical trials that use survival analysis to analyze composite endpoints. Our objective was to re-analyze data from previously published registry-based randomized controlled trials that produced hazard ratios using win statistics to evaluate the correspondence between them. Good correspondence was defined as both results being positive,
