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To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective
Context. Studies of the internal kinematics of the LMC have provided a detailed view of its structure, largely thanks to the exquisite proper motion data supplied by the Gaia mission. However, line-of-sight (LoS) velocities, the third component of the stellar motion, are only available for a small subset of the current Gaia data, thus limiting studies of the kinematics perpendicular to the LMC dis
ImportanceThe genetic variation in patients with sensorineural hearing loss (SNHL) in the Nordic countries has not been previously reported.ObjectivesThe aim was to describe the genetic variation in a Swedish population and identify factors in favor of a high diagnostic yield.DesignThis was a prospective cohort study. Children with bilateral SNHL and adults with bilateral SNHL and clinically suspe
Purpose: To investigate the rates of knee reoperation and medical complications after meniscal repair versus partial meniscectomy (APM) up to 10 years after surgery. Methods: All patients ≥ 15 years old operated for a meniscal tear with meniscus repair or partial meniscectomy at Scania University Hospital were included, between year 2010 and 2014. Information was retrieved from patient records unt
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ-diversity), either due to reduced β-diversity amplifying diversity loss or increased β-diversity dampening diversity loss. Additionall
Motivation Efforts to address health disparities are often limited by the lack of robust computational tools for inferring genetic ancestry by calculating an individual's genetic similarity to continental groups. We have already shown that a preferred alternative to self-described race is using ancestry-informative markers (AIMs) that can be classified into ancestral components and used to estimat
Magnetic resonance imaging (MRI) enables non-invasive monitoring of healthy brain development and disease. Widely used higher field (>1.5 T) MRI systems are associated with high energy and infrastructure requirements, and high costs. Recent ultra-low-field (<0.1 T) systems provide a more accessible and cost-effective alternative. However, it remains uncertain whether anatomical ultra-low-field neu
This study examines the effectiveness of LU-PZE, a web-based interactive tool designed to help students visualize and interact with fundamental concepts in automatic control. A total of 200 students enrolled in an introductory course on automatic control had the option to use LU-PZE as an additional resource for learning. LU-PZE offers users randomized quizzes, structured assignments, and real-tim
Introduction As care and rehabilitation poststroke are increasingly moving into persons’ home environment, the importance of support from social networks in self-management and rehabilitation has emerged as an important topic for research and practice. While there are instruments used to assess social support and collective efficacy, a clearer scope of the availability and quality of these instrum
We investigated the element-specific electronic structure and charge-carrier dynamics of a single-crystal ferromagnet CoS2 with complementary x-ray spectroscopy techniques. Hard x-ray photoemission (HAXPES) is used to provide crucial information on the bulk electronic structure and chemical bonding in CoS2 that is compared against the isoelectronic paramagnet CoSe2. The Co 1s core-level line shows
Purpose: This systematic literature review aims to develop a comprehensive understanding of effort as a multidimensional construct in individuals with impaired swallowing and/or spoken communication. Method: A comprehensive literature search was conducted across three data-bases: PubMed/MEDLINE, Embase, and CINAHL, covering publications from 1966 to 2024. The search included terms related to commu
Importance: Developing disease-modifying treatments is a priority for Alzheimer disease research. Objective: To determine the potential of plasma phosphorylated tau 217 (p-tau217) and tau positron emission tomography (PET) to assess disease modification in treatment trials. Design, Setting, and Participants: This diagnostic/prognostic study used longitudinal data from the Anti-Amyloid Treatment in
This article explores efforts to integrate human rights into Swedish education during the early post-war era (1948–1966). Focusing on how human rights were conceptualized and justified, the study addresses a significant gap in the historiography of human rights education by investigating its development prior to the 1970s.By examining materials from the National Board of Education, and the first tThis article explores efforts to integrate human rights into Swedish education during the early post-war era (1948–1966). Focusing on how human rights were conceptualized and justified, the study addresses a significant gap in the historiography of human rights education by investigating its development prior to the 1970s.By examining materials from the National Board of Education, and the first t
This Letter presents the first measurement of event-by-event fluctuations of the net number (difference between the particle and antiparticle multiplicities) of multistrange hadrons Ξ- and Ξ¯+ and its correlation with the net-kaon number using the data collected by the ALICE Collaboration in pp, p-Pb, and Pb-Pb collisions at a center-of-mass energy per nucleon pair sNN=5.02 TeV. The statistical ha
First measurements of hadron-Λ (h-Λ) azimuthal angular correlations in p-Pb collisions at sNN =5.02 TeV using the ALICE detector at the Large Hadron Collider are presented. These correlations are used to separate the production of associated Λ baryons into three different kinematic regions, namely those produced in the direction of the trigger particle (near side), those produced in the opposite d
