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OBJECTIVE: During the past few decades, a rapidly increasing incidence of childhood type 1 diabetes (T1D) has been reported from many parts of the world. The change over time has been partly explained by changes in lifestyle causing rapid early growth and weight development. The current study models and analyzes the time trend by age, sex, and birth cohort in an exceptionally large study group.RES

The building permit is usually the final decision of urban governance for public authorities, whereby the private actor is given the right to construct at the urban plot. But in urban areas there is an urban context, which calls the attention to the need of a planning perspective of the assembled built environment. Detailed plans are required, and they ought to be considered in a total urban or mu

Over the years, with advances in our understanding of soft tissue tumors, availability of an increasing number of diagnostic ancillary tests, and matured biopsy techniques with or without image guidance, needle biopsy investigation of a soft tissue lesion has largely replaced open excisional biopsy as the primary diagnostic tool to establish malignancy and to assess histologic type and grade. Fine

In 1952, plans to convert Lake Sanabria (Zamora) into a reservoir for hydroelectric production sparked a press campaign that reached the front pages of the Spanish national press. At the intersection of environmental and political history, this article examines the controversy surrounding the protection of the lake and its designation as a «Picturesque Site» («Paraje Pintoresco») in 1953, under th

Based on material collected with sweep nets, malaise traps and through rearing, the knowledge of the Swedish Chalcidoidea fauna is enhanced by new data on taxa occurring here, including new information on the biology for some of the species. Taxa reported as new to Sweden include one family (Neodiparidae), one genus (Neodipara Erdös) and 33 species in six families: Encyrtidae: Homalotylus platynas

This chapter describes the different types of non-continent urinary diversions, discusses indications, and summarizes common general and specific complications as well as the issue of quality of life. Non-continent urinary diversions are frequently used for lower urinary tract reconstruction after radical cystectomy. Ileal conduits are the most common form of incontinent diversion, followed by col

A large panorama of lesions is accessible to fine-needle aspiration cytology (FNAC). This chapter focuses on lesions of the salivary glands, as well as tumors of the tongue and oral and nasal cavities. Some unusual lesions of the neck will also be presented. Aspiration cytology of thyroid, parathyroid, and lymph nodes is dealt with in other chapters. When confronted with a mass lesion in the head

Instantaneous wave free ratio (iFR) may be a viable alternative to FFR. iFR is a novel measurement of the hemodynamic relevance of coronary lesions which doesn’t require the use of hyperemic agents.

Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and neurodegeneration in ischemic stroke. Inhibition of plasma kallikrein (PK) – a key component of the KKS – in the acute phase of ischemic stroke has been reported to reduce thrombosis, inflammation, and damage to the blood-brain barrier. However, the role of PK during the recovery phase after cerebral ischemia is

Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal d

Street experiments are proliferating in cities worldwide and have emerged as an approach to transform urban mobility and public space. Previous research attests to the broad spectrum of street experimentation and its variety of stakeholders, aims, methods, and impacts. In this article, we probe this multi‐faceted nature through a study of the landscape of street experimentation as it evolved in on

(1) Background: Patients’ experiences and satisfaction with their treatment are becoming increasingly important in the context of quality assurance, but the measurement of these parameters is accompanied by several disadvantages such as poor cross-country comparability and methodological problems. The aim of this review is to describe and summarize the process of measuring, publishing, and utilizi

Background: Glatiramer acetate (GA) is a well-established treatment option for patients with clinically isolated syndrome and relapsing–remitting multiple sclerosis (MS) with few side effects. The double transgenic mouse model spontaneous opticospinal encephalomyelitis (OSE), based on recombinant myelin oligodendrocyte glycoprotein35-55 reactive T and B cells, mimicks features of chronic inflammat

Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) are antibody mediated CNS disorders mostly affecting the optic nerve and spinal cord with potential severe impact on the visual pathway. Here, we investigated inflammation and degeneration of the visual system in a spontaneous encephalomyelitis animal model. We used double-tra