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We present a non-contact platelet functional analysis platform based on acoustic trapping of platelet clusters and activation monitoring using impedance spectroscopy. The system was characterized using polystyrene particles and human platelets. The system was also capable of transferring platelets from plasma into a controlled buffer. Trapped platelets were activated using 20 and 40 μM TRAP and th
Studies of nanoconfined circular DNA are of interest both from a biological as well as a fundamental polymer physics perspective. We here present the use of nanofluidic channels as a tool for comparing statics and dynamics of the linear and circular configuration of the same DNA molecule.
The theme of innovation (understood as the introduction of new products, processes, or organizational forms in the marketplace) is interdisciplinary in nature. Economic geographers started participating in the field early, but scholars from fields such as economics and innovation studies have also contributed to understanding the geography of innovation. Core topics have been to examine how innova
BACKGROUND: Chronic leg ulcers remain a challenge to the treating physician. Such wounds often need skin grafts to heal. This necessitates a readily available, fast, simple, and standardized procedure for grafting.OBJECTIVES: The aim of this work was to test a novel method developed for outpatient transplant procedures.METHODS: The procedure employs a handheld disposable dermatome and a roller min
Objective. To describe the effects of implementing a robotic surgical program within gynecologic oncology and gynecology at a tertiary referral hospital. Design: Prospective study. Setting: University Hospital, Lund and Lund University, Sweden. Methods. Based on prospective data retrieved for all patients, we evaluated intraoperative times, estimated blood loss, rate of conversion and rate of intr
Field choice was recorded during counts of geese in South-west Scania, South Sweden in autumn (October and November) and in winter (January), 1977/1978-2011/2012. Sugar beet spill was the most important field type in autumn and during the last ten years also in winter. Bean Geese Anserfabalis used this food source when the study started while Canada Geese Branta canadensis, Greylag Geese Anser ans
Aim: The aim of this study was to explore and understand the complexity of ageing in relation to factors of importance for extending working life. Method: Discourse analysis of documents was used in an integrative review including 128 articles. Result: Four different conceptualisation of ageing are shown to affect older workers’ ability to extend their working life: (a) biological ageing people’s
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key ques
Support of the anterior and posterior vaginal wall is related to the support and position of the vaginal apex. Therefore, support of the vaginal apex, with or without a concomitant procedure to prevent the formation of an enterocele, is the base for prolapse surgery. A number of surgical approaches, vaginal, open or laparoscopic have been described with or without preservation of the uterus. The u
This paper presents an investigation of a skeleton based coupling technique used for the assembly of different modules, i.e. walls and floors, in a modular finite element model. For simplicity the skeleton is introduced in the intersections of the panels. In this way all panels can be constrained to the global skeleton, leading to a removal of the constrained degrees of freedom (DOFs) in the indiv
The objectives were to evaluate possible associations between the SLC30A8 R325W polymorphism and gestational diabetes mellitus (GDM) as well as postpartum development of type 2 diabetes. Furthermore, we wanted to confirm the prevalence of zinc transporter 8 autoantibodies (ZnT8A), as previously reported, in a larger population and study its predictive value in relation to other β cell specific aut
Genetic and epigenetic factors may predispose women to polycystic ovary syndrome (PCOS), a common heritable disorder of unclear etiology. Here we investigated differences in genome-wide gene expression and DNA methylation in adipose tissue from 64 women with PCOS and 30 controls. In total, 1720 unique genes were differentially expressed (Q < 0.05). Six out of twenty selected genes with largest exp
OBJECTIVE: The aim of this investigation was to describe tumour characteristics, treatments and survival in patients with urinary bladder cancer (UBC) in a national population-based cohort, with special reference to gender-related differences.MATERIAL AND METHODS: All primary UBC patients with urothelial pathology reported to the Swedish National Registry of Urinary Bladder Cancer (SNRUBC) from 19
AIMS: Myocardial salvage, determined by cardiac magnetic resonance imaging (CMR), is used as end point in cardioprotection trials. To calculate myocardial salvage, infarct size is related to myocardium at risk (MaR), which can be assessed by T2-short tau inversion recovery (T2-STIR) and contrast-enhanced steady-state free precession magnetic resonance imaging (CE-SSFP). We aimed to determine how T
Streptococcus pneumoniae commonly inhabits the nasopharynx as a member of the commensal biofilm. Infection with respiratory viruses, such as influenza A virus, induces commensal S. pneumoniae to disseminate beyond the nasopharynx and to elicit severe infections of the middle ears, lungs, and blood that are associated with high rates of morbidity and mortality. Current preventive strategies, includ
Our hypothesis was that carbohydrate, fat, and protein contents of meals affect satiety, glucose homeostasis, and hormone secretion. The objectives of this crossover trial were to examine satiety, glycemic-insulinemic response, and plasma peptide levels in response to 2 different recommended diabetes diets with equivalent energy content. One traditional reference breakfast and one test breakfast,
Treatment of high-risk childhood neuroblastoma is a clinical challenge hampered by a lack of reliable neuroblastoma mouse models for preclinical drug testing. We have previously established invasive and metastasising patient-derived orthotopic xenografts (PDXs) from high-risk neuroblastomas that retained the genotypes and phenotypes of patient tumours. Given the important role of the tumour microe
