UNLABELLED: Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.CLINICAL TRIALS REGISTRAT

Pulmonary arterial hypertension (PAH) is a rare disease that affects the pulmonary vasculature. Characterized by increased pulmonary arterial pressures and vascular resistance, it causes right heart failure (HF), and premature death. The main symptom, exertional dyspnoea, is non-specific where patient’s and doctor’s delay often lead to diagnosis in advanced stages. Despite development of PAH speci

Vilka föremålstyper finns samlingen? Ger de oss en ny kunskap? Varför samla på gamla fornsaker? Vad gör samlaren till en samlare? Hur påverkar samlarens livsbiografi samlandet? Vilken roll har tidens värderingar och lagstiftning? Vilken relevans har fornsakssamlingar idag?Samlaren och friherren Carl Gyllenstiernas fornsakssamling på Krapperup i nordvästra Skåne är utgångspunkten för denna arkeolog

We propose a novel hybrid approach that integrates Neural Ordinary Differential Equations (NODEs) with Bayesian optimization to address the dynamics and parameter estimation of a modified time-delay-type Susceptible-Infected-Removed (SIR) model incorporating immune memory. This approach leverages a neural network to produce continuous multi-wave infection profiles by learning from both data and th

The transition towards a circular economy (CE)relies on a supporting policy framework. TheEU is currently recognised as a global leader inclimate action and has adopted a comprehensivepolicy package to reach the objectives set outin its Circular Economy Action Plan. This paperexamines current and planned CE policies, theirkey impact on industries – with a focus on es-tablished manufacturing indust

This chapter explores and compares the different uses of images of human fetuses in a number of Swedish television programs dealing with the controversial issue of fetal research in the period from the late 1960s to the late 1980s. Drawing on previous discussions on fetal imagery and ‘the public fetus,’ the analysis focuses on the different representational strategies used in a sample of programs

BACKGROUND: Malaria remains a significant public health concern, especially for the deadliest parasite, Plasmodium falciparum. During acute malaria, various cytokines, including osteopontin (OPN), regulate the immune response. OPN has been shown to be protective against malaria in mice. Nonetheless, its precise function and potential ability to control parasites during acute malaria in humans rema

Odlingstekniken monokultur bygger på en ekonomisk rationalism som säger att hela odlingsytan ska upptas av den gröda eller det trädslag som är föremål för markägarens kommersiella intresse. Därtill ska all annan växtlighet betraktas som ett ogräs som konkurrerar med odlingsverksamheten om ljus, näring och utrymme. Monokulturen, samt dess ekonomiskt-rationella motivering, dominerar idag odlingsland

This paper presents the experimental verification of a cooling concept based on hollow direct air cooling windings for the rotor of an electrically excited synchronous machine (EESM) with the application of traction drive for electric vehicles (EVs). Developing the performance of EESMs is important for the EV industry since it is today so reliant on permanent magnets. The idea behind the cooling c

BACKGROUND: Most trials that have shown a benefit of beta-blocker treatment after myocardial infarction included patients with large myocardial infarctions and were conducted in an era before modern biomarker-based diagnosis of myocardial infarction and treatment with percutaneous coronary intervention, antithrombotic agents, high-intensity statins, and renin-angiotensin-aldosterone system antagon

Background: Measuring and interpreting vital signs in pediatric patients recovering from anaesthesia, particularly those up to 36 months old, is challenging. Nurses’ decision-making regarding the level of monitoring must balance patient safety with individualized care. This study aimed to explore the perceptions of critical care nurses and registered nurse anesthetists regarding their experiences

Grassroots innovations are seen as important contributors to sustainability transitions, however, given their dependence on place-specific conditions they face diffusion challenges. Responding to previously outlined gaps regarding conceptualisation and exploration of the spatiality of grassroots innovations, this paper introduces a conceptualisation of nomadic grassroots innovations. These are gra

India's ongoing energy transitions are a systemic response to addressing critical challenges associated with climate change. Importantly, it leverages decarbonization as a strategic pivot to simultaneously mitigate and adapt to climate risks. The decarbonization agenda is largely skewed towards mitigation, struggling with adaptation alignments. Energy justice is a core dimension of adaptation inte

Exposure time to heat is increasing with climate change. Heat exposure thresholds are important to inform heat early warning systems, and legislation and guidance for safety in the workplace. It has already been stated that thresholds can be lower for vulnerable groups, including the elderly, pregnant women, children, and those with pre-existing medical conditions due to their reduced ability to t

A neurological dogma is that the contralateral effects of brain injury are set through crossed descending neural tracts. We have recently identified a novel topographic neuroendocrine system (T-NES) that operates via a humoral pathway and mediates the left-right side-specific effects of unilateral brain lesions. In rats with completely transected thoracic spinal cords, unilateral injury to the sen