The development of biotechnological products is becoming more and more expensive. One type of protein attracting a great deal of attention in the biopharmaceutical industry is antibodies, which was used in this work. The cost of producing antibodies is, however, high, mainly due to the downstream processing, which constitutes 50–80% of the total cost. This work describes model-based methods to des

The concept of personality is scrutinized as used both in common parlance and in more sophisticated frames of reference. Current multidimensional models are criticized for their reliance on self-descriptive questionnaires and for their lack of a hierarchical dimension, differentiating more or less decisive determinants of behavior. A possible psychoanalytic model is viewed with more benevolence bu

Modelling of 2D resistivity imaging was done in order to understand the principle resolution of the technique in different geological situations, and for assessing the behaviour of the interpretation methods under controlled circumstances. The Wenner array was used throughout. The results show that the 1D approximation only provides reasonable results in environments with very gradual lateral resi

We propose and investigate a unifying class of sparse random graph models, based on a hidden coloring of edge-vertex incidences, extending an existing approach, random graphs with a given degree distribution, in a way that admits a nontrivial correlation structure in the resulting graphs. The approach unifies a number of existing random graph ensembles within a common general formalism, and allows

The article discusses the sociocultural dimensions to the Chinese courtesy titles 'nüshi' (ladies) and 'xiansheng' (gentlemen).

This paper reflects how anti-islanding protection has developed with increasing DG penetration. Starting from a local issue it has developed to possibly affect system security. The focus here is on how islanding detection methods and anti-islanding protection settings relate to distribution level and TSO requirements. It is confirmed using field measurements and simulations that the most common pa

The reaction of [Co2{μ-C2(CO2Me)2}(CO)6] with the ligand diphenyl-2-thienylphosphine, PPh2(C4H3S), yields the complexes [Co2{μ-C2(CO2Me)2}(CO)5{PPh2(C4H3S)}] (1) and [Co2{μ-C2(CO2Me)2}(CO)4{PPh2(C4H3S)}2] (2). The related complex [Co3(μ3CMe)(CO)9] reacts with the same ligand to give [Co3(μ3-CMe)(CO)8{PPh2(C4H3S)}] (3) and [Co3(μ3-CMe)(CO)7{PPh2(C4H3S))2] (4). Thermolysis of 1 at 80°C leads to part

Antigenic variation of surface proteins allows microorganisms to evade the immune system of the infected host. This phenomenon represents an apparent paradox, because the variable protein must retain an important function, while its antigenic properties vary extensively. The surface associated M protein of Streptococcus pyogenes, a common human pathogen, exhibits antigenic variation due to an N-te

All-trans retinoic acid deficiency resulting from ethanol's interference with the synthesis of all-trans retinoic acid from retinol was recently suggested to cause the malformations of the fetal alcohol syndrome. Phenytoin, carbamazepine and valproate, might be teratogenic because they lower the concentration of all-trans retinoic acid in serum, by inducing the enzyme systems in the liver responsi

This thesis is divided into two separate parts. The first part is about Dynamic Programming for non-trivial optimal control problems. The second part introduces some useful tools for analysis of stability and performance of systems with time-varying delays. The two papers presented in the first part attacks optimal control problems with finite but rapidly increasing search space. In the first pap

A feed control strategy, based on estimated sugar concentrations, was developed with the purpose of avoiding severe inhibition of the yeast Saccharomyces cerevisiae during fermentation of spruce hydrolyzate. The sum of the fermentable hexose sugars, glucose and mannose, was estimated from on-line measurements of carbon dioxide evolution rate and biomass concentration by use of a simple stoichiomet

Branhamella catarrhalis was isolated from the nasopharynx in 55% of 40 noncompromised adult patients suffering from acute laryngitis. Diplococcus pneumoniae and haemophilus influenzae were found in another 5 and 8%, respectively; one patient had group A streptococci in the throat specimen. In 90% of the patients the laryngitis complaints were preceded by symptoms of an acute respiratory tract infe

The ECL cells in the oxyntic mucosa secrete histamine in response to gastrin, stimulating parietal cells to produce acid. Do they also operate under nervous control? The present study examines histamine mobilization from rat stomach ECL cells in situ in response to acute vagal excitation and to food or gastrin following vagal or sympathetic denervation. Applying the technique of microdialysis, we

This article highlights the old wisdom that technology is socially constructed. By using examples from a study of how German machinery manu-facturing firms and North American user industries act and think while developing and implementing advanced technology, and reflecting on these examples to elucidate Swedish manufacturing culture, the study highlights how knowledge about industrial behaviour c

Objective: To investigate the role of anti-cyclic citrullinated peptide antibody (anti-CCP) for the prediction of radiological outcome in patients with early rheumatoid arthritis. Methods: Anti-CCP was assessed at baseline in 379 patients with early rheumatoid arthritis ( disease duration

Rapporten behandlar politiska åtgärder för att miljöanpassa batterier, så att läckage av bland annat kvicksilver och kadmium till naturen kan förhindras. Olika typer av styrmedel såsom lagstiftning, frivilliga åtaganden från branschen, ekonomiska åtgärder och informationskampanjer analyseras med avseende på hur effektiva de varit samt vilka problem och hinder som funnits för att uppnå de formulera