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We conducted a randomized phase III trial to compare the efficacy and safety of two purine analogs, cladribine and fludarabine, with high-dose chlorambucil, in patients with previously untreated chronic lymphocytic leukemia (CLL). Between 1997 and 2004, 223 patients with CLL were randomly assigned to cladribine, fludarabine or chlorambucil, for six cycles of therapy with frequent health-related qu
Postnatal gut maturation in neonatal mammals, either at natural weaning or after precocious inducement, is coinciding with enhanced enzymes production by exocrine pancreas. Since the involvement of enzymes in gut functional maturation was overlooked, the present study aimed to investigate the role of enzymes in gut functional maturation using neonatal rats.
The complement system is fundamental to both innate and adaptive immunity and can be initiated via the classical, lectin or alternative pathways. Cleavage of C4 by MASP-2, the initiating protease of the lectin pathway, is a crucial event in the activation of this pathway, preceding the eventual formation of the C3 convertase (C4bC2a) complex on the pathogen surface. Interactions required for the c
Characterized tissue with pathological grading and blood samples as well as other biofluids forms the basis for all biobanks as a resource in modern life science. Biobanks are accessed to measure biological components that can be used to monitor the status of health and disease in individual samples and population groups. The biomarker diagnostics area, predicting drug efficacy, stratification of
Rapporten sammanfattar en studie om äldres mobilitet i en skånsk landsbygdskommun. Kommunen karakteriseras av en hög andel äldre, boendes i utkanten av en expansiv region, samt ett betydande inslag av personer som i senare medelåldern väljer att bosätta sig permanent i sina fritidshus. Fokusgruppsdiskussioner visar på skillnader och likheter i hur man ser på sina resmöjligheter både idag och i mor
The few-picosecond (ps) decay of terahertz (THz) photoconductivity typically observed for conjugated polymer:fullerene blends (at excitation fluencies ∼10(15) photons/cm(2) per pulse) is shown to be a result of charge pair annihilation for two polymer:PCBM blends. At a factor of 100 lower excitation density, the THz decay is in the hundreds of ps time scale, implying that very high carrier mobilit
Since the early 1990s, the European Union (EU) has presented itself as a leader on climate change. Recently, however, this picture has been challenged in the media and by non-governmental organization representatives. The aim of our article is to evaluate the Union's present role in the area of international climate politics. We do this by scrutinizing the EU's own role conception, but also, and p
An experiment was carried out to examine the subjective estimation of fire growth for young adults and their perceived ability to extinguish fires. In the experiment, participants filled out a questionnaire consisting of two parts. The first part involved prediction of fire growth, and the participants were asked to estimate the times between different stages of fires. The second part involved est
Artikel om de första svenska filmerna i Kristianstad 1908-1910.
The aim of this study was to investigate a combination of satellite images of leaf area index (LAI) with process-based vegetation modeling for the accurate assessment of the carbon balances of Swedish forest ecosystems at the scale of a landscape. Monthly climatologic data were used as inputs in a dynamic vegetation model, the Lund Potsdam Jena-General Ecosystem Simulator. Model estimates of net p
Popular Abstract in English Atherosclerosis is a disease of medium and large sized vessels of our bodies that is mainly characterized by the deposition of lipids in the vessel walls. Increased lipid levels in the blood of an individual, because of lifestyle habits but also because of genetics, can lead to the formation of an “atherosclerotic plaque”. Thus, although lipids are important for the norAtherosclerosis is a chronic inflammatory disease of medium and large vessels of the body which is mainly characterized by the formation of lipid rich plaques within the arterial tissue. It is the most common cause of cardiovascular disease leading to clinical manifestations of coronary artery and cerebrovascular disease. Immune responses targeting modified low density lipoprotein (LDL) play an im
Twelve fossil species of Proteaceous pollen, predominantly attributable to Proteacidites and Beaupreaidites, were recovered from the Maastrichtian-Paleocene sedimentary succession of the Garden Cove Formation on Campbell Island, the southernmost landmass of the Zealandia continent. Among these are two new species, Proteacidites campbellensis and Proteacidites hortisinus. The high diversity of Prot
This article critically studies the hegemonic discursive construction of the EU’s current (2012) economic crisis, as it is articulated by political and economic elites and by mass media. The study focuses on the political economy of the particular crisis and through the critical concept of reification, the study emphasizes the hegemonic naturalization of the economic crisis by the “free market” ec
Charge generation and recombination are studied in blend films of poly-3-hexylthiophene (P3HT) and [6,6']phenyl C61 butyric acid methyl ester (PCBM) using ultrafast transient absorption spectroscopy. We find that the charge generation yield depends upon both blend film composition and thermal annealing. The data suggest that recombination occurs over a wide range of time scales and that, in the le
The ATLAS Transition Radiation Tracker (TRT) is the outermost of the three sub-systems of the ATLAS Inner Detector at the Large Hadron Collider at CERN. It consists of close to 300,000 thin-wall drift- tubes (straws) providing on average 30 two-dimensional space points for charged particle tracks. The straws have 0.13 mm resolution and measure tracks with vertical bar eta vertical bar < 2 and p(T)
