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Solvation of protein surface charges plays an important role for the protonation states of titratable surface groups and is routinely incorporated in low dielectric protein models using surface accessible areas. For many-body protein simulations, however, such dielectric boundary methods are rarely tractable and a greater level of simplification is desirable. In this work, we scrutinize how charge
Field experiments with ISA (intelligent speed adaptation) were carried out in Hungary and Spain in 2003 and 2004, respectively. Twenty private vehicles in each country were equipped with two kinds of systems: (1) support via an active accelerator pedal (AAP) and (2) warning via beep signals and a flashing red light when the speed limit was exceeded (BEEP). The test drivers drove for a month with b
Collagen-induced arthritis (CIA) is induced in H-2(q) mice after immunization with rat type II collagen (CII). The immunodominant T cell epitope on heterologous CII has been located to CII256-270. We have previously shown that TSC transgenic mice, which express the heterologous epitope in type I collagen (CI), e.g. in skin, are tolerized against rat CII and resistant to CIA. In this study we trans
Let ${\bold D}$ denote the unit disk in the complex plane and let $m$ be the area Lebesgue measure on ${\bold D}$. Given a positive integrable function $w$ (a weight) on ${\bold D}$, let $L^p_{\rm a}(w)$ denote the collection of analytic functions $f$ on ${\bold D}$ such that $|f|^pw$ is integrable. Given an analytic function $g$ on ${\bold D}$, the operator $T_g$ is defined by $T_g f(z) = \int_
This paper illustrates a novel method to analyze artificial neural networks so as to gain insight into their internal functionality. To this purpose, we will show analysis results of some feed-forward-error-back-propagation neural networks for image processing. We win describe them in terms of domain-dependent basic functions, which axe, in the case of the digital image processing domain, differen
An in-house-made alignment system for deep X-ray lithography is presented that features low costs, low weight and little demand in space. Synchrotron radiation illuminates alignment marks on mask and substrate. The radiation transmitted through these alignment marks is detected by X-ray-sensitive diodes. The mask is fixed to the vacuum chamber, whereas the substrate is mounted on a six-axis kinema
We recommend prophylaxis in haemophilic children with an inhibitor as a way of preventing the musculoskeletal impairment that is likely to affect them. This approach has been used for children without inhibitors with excellent results. If prophylaxis is not feasible, we suggest that intensive on-demand treatment should be given. Two agents, recombinant activated FVII (rFVIIa) and activated prothro
Stellar clusters are highly useful as tools for determination of distances, ages and abundances of heavy elements of galaxies, also at larger distances. Their utility for these purposes has, so far, been severely limited, mainly due to image crowding. The introduction of Extremely Large Telescopes (ELTs) with full adaptive optics (AO) and near diffraction limited performance should imply a drastic
Many models currently discussed in PR studies lack a supporting meta-theory of what managing communication is about, and consequently paint a simplistic picture of what communicating with publics or managing phenomena such as reputation actually means. While it is common to speak of “building” trust or “constructing” images, “cultivating” seems a more appropriate metaphor. Publics are complex, dyn
The capillary filtration coefficient (CFC) is assumed to reflect both microvascular hydraulic conductivity and the number of perfused capillaries at a given moment (precapillary sphincter activity). Estimation of hydraulic conductivity in vivo with the CFC method has therefore been performed under conditions of unchanged vascular tone and metabolic influence. There are studies, however, that did n
How do different levels of sibling competition affect nestling growth strategies? We investigated this through the effect of different levels of per capita feeding rate on the average growth rate of nestlings and on individual growth strategies within broods. To manipulate sibling competition, we transferred marsh tit nestlings between nests creating broods with fewer (reduced) or more (enlarged)
Purpose: The aim of this study was to validate the conceptual definitions of accessibility and usability, and to explore differences between objective accessibility assessments and subjective ratings of usability in different client groups. Method: The Housing Enabler and the Usability in My Home instruments were used for 131 persons above 18 years of age, living in ordinary housing and receiving
Objective: The objective was to analyse relationships between inspiratory and expiratory static and dynamic elastic pressure-volume (P-el/V) curves in healthy pigs. Design: The modulated low flow method was developed to allow studies also of the expiratory P-el/V curves. Static P-el/V (P-el,P-st/V) and dynamic P-el/V (P-el,P-dyn/V) loops were studied in healthy pigs. Setting: Animal research labor
Objectives: The strategies used to support smoking cessation among quitters were investigated according to year of smoking cessation and sociodemographic characteristics. Methods: The 2004 public health survey in Skane, Sweden, is a cross-sectional study. A total of 27 757 people aged 18-80 answered a postal questionnaire. The participation rate was 59%. Different strategies to support smoking ces
Autumn migration of adult Eurasian hobbies Falco subbuteo from Europe to southern Africa was recorded by satellite telemetry and observed routes were compared with randomly simulated routes. Two non-random features of observed routes were revealed: (i) shifts to more westerly longitudes than straight paths to destinations and (ii) strong route convergence towards a restricted area close to the equ
The aim of the present study was to investigate whether current smoking, ex-smoking, or amount of current smoking among postmenopausal women was associated with plasma levels of testosterone, and rostenedione, and DHEAs. About 65,000 women in Sweden have participated in two population-based prospective cohort studies where blood samples were collected at baseline, and information on life-style, re
