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Full-field Electroretinography in Age-related Macular Degeneration : can retinal electrophysiology predict the subjective visual outcome of cataract surgery?

Purpose: Predicting the visual gain from cataract surgery when the main cause of vision loss is age-related macular degeneration may be difficult and warrants the need for an objective predictor of subjective outcome. Full-field electroretinography is an objective measure of overall retinal function. We therefore wanted to study if full-field electroretinography can predict subjective visual outco

The relationship between red cell distribution width and all-cause and cause-specific mortality in a general population

Red Cell Distribution Width (RDW) could be a risk factor for developing various chronic diseases, and seems to be a prognostic marker in patients with cardiovascular disease (CVD) or cancer. Our aim was to explore the association between RDW and all-cause and cause-specific mortality in a general population. RDW was measured in 27,063 participants (aged 45-73 years) from the population-based Malmö

Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case-Control and Case-Crossover Settings : A Systematic Review and Meta-Analysis

Objective: The aim of this systematic review and meta-analysis (SR-MA) was to identify signaling molecule profiles and blood-derived biomarkers in migraine and cluster headache (CH) patients. Background: Currently no migraine and CH valid biomarkers are available. Blood tests based on biomarker profiles have been used to gather information about the nervous system. Such tests have not yet been est

The Swedish National Pediatric Cataract Register (PECARE) : incidence and onset of postoperative glaucoma

Purpose: The aim was to report cumulative incidence and time of onset of postoperative glaucoma in a paediatric early cataract surgery cohort. Methods: Data were retrieved from the Pediatric Cataract Register (PECARE), a prospective register of Swedish cataract operations before 8 years of age. All eyes with surgery between January 2007 and December 2014 and a registered follow-up were included. C

Problemet med unga i grupp

Recension av Martin Ericsson och Andrés Brink Pintos, Den bråkiga staden. Ungdomsupplopp och ungdomspolitik i efterkrigstidens Stockholm

Ground-based remote sensing of the shallow subsurface : Geophysical methods for environmental applications

Noninvasive methods for the characterization of shallow subsurface have been used routinely for some 20–30 years. The growth in these methods has been driven by a variety of breakthroughs in the use of electrical, electromagnetic, and seismic methods, to mention only the most common techniques. Increasing field capabilities and computational power have yet to yield all their potential fruits. In t

Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal

Volatile compounds emitted by bacteria are often sensed by other organisms as odours, but their ecological roles are poorly understood1,2. Well-known examples are the soil-smelling terpenoids geosmin and 2-methylisoborneol (2-MIB)3,4, which humans and various animals sense at extremely low concentrations5,6. The conservation of geosmin biosynthesis genes among virtually all species of Streptomyces

ETV in infancy and childhood below 2 years of age for treatment of hydrocephalus

Purpose: Age and etiology play a crucial role in success of endoscopic third ventriculostomy (ETV) as a treatment of obstructive hydrocephalus. Outcome is worse in infants, and controversies still exist whether ETV is superior to shunt placement. We retrospectively analyzed 70 patients below 2 years from 4 different centers treated with ETV and assessed success. Methods: Children < 2 years who rec

Depression in People With Dementia and Caregiver Outcomes : Results From the European Right Time Place Care Study

Objective: To investigate the cross-sectional associations between depression in people with dementia and both caregiver burden and quality of life in 8 European countries, and to test these associations compared with the presence of other neuropsychiatric symptoms. Design: Cross-sectional study. Setting and Participants: In total, 1223 dyads comprised of informal caregivers and people with dement

Monozygotic twins with myocarditis and a novel likely pathogenic desmoplakin gene variant

Myocarditis most often affects otherwise healthy athletes and is one of the leading causes of sudden death in children and young adults. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically determined heart muscle disorder with increased risk for paroxysmal ventricular arrhythmias and sudden cardiac death. The clinical picture of myocarditis and ARVC may overlap during the early

Computational Studies of Nitrogenase

AbstractNitrogenase is the only enzyme that can convert the inert nitrogen molecule to ammonia, so that it can be used for biomass production and in biosynthetic pathways. It contains a complicated acitve site, composed of eight metal ions, nine sulfur ions and one carbide ion (the FeMo cluster). Although it has been thoroughly studied with crystallographic, biochemical, kinetic, spectroscopic and

Partington-rochelle : When to drain the pancreatic duct and why

Chronic pancreatitis should be managed medically until a surgical correctable complication develops. The ‘ideal’ operation should have a low mortality and morbidity, be easy to perform, provide pain relief, rectify the structural abnormalities such as bile duct obstruction, and not augment exocrine and endocrine insufficiency. Direct measurements made at the time of laparotomy have shown that at l

Curatively intended surgery for exocrine pancreatic cancer

Resective surgery for exocrine pancreatic cancer can currently be performed with little or no hospital mortality. The operation is most often performed as a Whipple resection, but several modifications (e.g., subtotal pancreatectomy) have been advocated. The pylorus-preserving modification has gained in popularity, although its ability to remove all lymph nodes has been questioned. Total pancreate

Exploring the enzymatic and antibacterial activities of novel mycobacteriophage lysin b enzymes

Mycobacteriophages possess different sets of lytic enzymes for disruption of the complex cell envelope of the mycobacteria host cells and release of the viral progeny. Lysin B (LysB) enzymes are mycolylarabinogalactan esterases that cleave the ester bond between the arabinogalactan and mycolic acids in the mycolylarabinogalactan-peptidoglycan (mAGP) complex in the cell envelope of mycobacteria. In

1,2 Propanediol utilization by Lactobacillus reuteri DSM 20016, role in bioconversion of glycerol to 1,3 propanediol, 3-hydroxypropionaldehyde and 3-hydroxypropionic acid

The objective of the presented work is to demonstrate the metabolism of 1,2 propandiol by Lactobacillus reuteri and to elucidate the metabolites produced during the process. This Metabolic pathway is crucial for biotechnological applications using L. reuteri in bioconversion of glycerol to industrially important plate-form chemicals. L. reuteri grown on minimal media containing 1,2 propanediol was

Preferential Killing of Tetraploid Colon Cancer Cells by Targeting the Mitotic Kinase PLK1

BACKGROUND/AIMS: Chromosomal instability is a well-known factor in the progression of different types of cancer, including colorectal cancer. Chromosomal instability results in severely rearranged karyotypes and aneuploidy. Tetraploidy constitutes an intermediate phase during the polyploidy/aneuploidy cascade in oncogenesis, and tetraploid cells are particularly resistant to chemotherapy. Whether

International, multicentre, observational study of fluid bolus therapy in neonates

AimTo assess the prevalence, types and indications for fluid bolus therapy in neonates with haemodynamic compromise.MethodsThis was a pragmatic, international, multicentre observational study in neonatal units across Australasia, Europe and North America with a predefined study period of 10–15 study days per participating neonatal unit between December 2015 and March 2017. Infants ≤28 days of age