NADH:quinone oxidoreductase or complex I is a large membrane bound enzyme complex that has evolved from the combination of smaller functional building blocks. Intermediate size enzyme complexes exist in nature that comprise some, but not all of the protein subunits in full size 14-subunit complex I. The membrane spanning complex I subunits NuoL, NuoM and NuoN are homologous to each other and to tw

A correntropy-based technique is proposed for the characterization and classification of respiratory flow signals in chronic heart failure (CHF) patients with periodic or nonperiodic breathing (PB or nPB, respectively) and healthy subjects. The correntropy is a recently introduced, generalized correlation measure whose properties lend themselves to the definition of a correntropy-based spectral de

Knowledge of the forest biomass and its change in time is crucial to understanding the carbon cycle and its interactions with climate change. LiDAR (Light Detection and Ranging) technology, in this respect, has proven to be a valuable tool, providing reliable estimates of aboveground biomass (AGB). The overall goal of this study was to develop a method for assessing AGB using a synergy of low poin

Popular Abstract in Swedish Sepsis, blodförgiftning, är ett potentiellt allvarlgt och komplicerat kliniskt syndrom samt är en av de vanligaste orsakerna till döden på intensivvårdsavdelningar. Cirka 200 per 100,000 invånare i Sverige drabbas årligen av svår sepsis. Sepsis är systemisk inflammatorisk reaktion mot mikrobiell invadering. Svår sepsis är den sepsis som associerad med en eller flera orgSepsis and subsequent organ failure remain the major cause of mortality in intensive care units in spite of significant research efforts. The lung is the most vulnerable organ affected by early hyper-inflammatory immune response in septic patients. On the other hand, the septic insult induces immune dysfunction in later phases of sepsis which in turn increases susceptibility to infections. The aim

Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin

When differential-algebraic equations of index 3 or higher are solved with backward differentiation formulas, the solution in the first few steps can have gross errors, the solution can have gross errors in the first few steps, even if the initial values are equal to the exact solution and even if the step size is kept constant. This raises the question of what are consistent initial values f

Over the past few decades, significant social and economic transformations had a relevant correspondence in processes of territorial complexification, urban fragmentation and spatial injustice. Literature and research shows that these processes have also a very important temporal dimension, associated to a transition from an industrial society of synchronized rhythms to more heterogeneous everyday

This paper focuses on hybrid organisations, which have both public and private sector elements. Therefore, stakeholders of hybrid organisations have different views regarding what to expect from the organisation and the role of stakeholders tend to be multifaceted. This creates ambiguity that imposes demands on the management of hybrid organisations. In this paper a stakeholder approach is used in

This study was performed between 2004 and 2011 at mail sorting facilities in Sweden. During this time, different interventions were performed. The first was a lighting intervention that had a positive impact on the postal workers, especially those with eyestrain. A new lighting system also improved the illuminance and gave better light distribution. The second intervention involved new personal sp

A global warming of 2 degrees C relative to pre-industrial climate has been considered as a threshold which society should endeavor to remain below, in order to limit the dangerous effects of anthropogenic climate change. The possible changes in regional climate under this target level of global warming have so far not been investigated in detail. Using an ensemble of 15 regional climate simulatio

Popular Abstract in Swedish Celiaki, även kallat glutenintolerans, är en tarminflammation orsakad av vissa sädesslag i kosten och förekommer hos både barn och vuxna. Sjukdomen drabbar ca 1% av befolkningen i västvärlden och betraktas som en av de vanligaste kroniska sjukdomarna bland svenska barn. Många individer med sjukdomen är oupptäckta och kan bara hittas via s.k. screening, d.v.s. att man leObjectives: Celiac disease is a common immune mediated enteropathy strongly associated with HLA-DQB1*02 (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical signs or being asymptomatic rendering screening a method for identification. However, less is known

Phytase is used as a feed additive for degradation of antinutritional phytate, and the enzyme is desired to be highly thermostable for it to withstand feed formulation conditions. A Bacillus sp. MD2 showing phytase activity was isolated, and the phytase encoding gene was cloned and expressed in Escherichia coli. The recombinant phytase exhibited high stability at temperatures up to 100 degrees C.

The aim of this paper is to introduce n-ary Hom-algebra structures generalizing the n-ary algebras of Lie type including n-ary Nambu algebras, n-ary Nambu-Lie algebras and n-ary Lie algebras, and n-ary algebras of associative type including n-ary totally associative and n-ary partially associative algebras. We provide examples of the new structures and present some properties and construction theo

Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function

PURPOSE. To examine in rodent models of retinitis pigmentosa (RP) the expression of the neuroprotectants metallothionein-I and -II and of megalin, an endocytic receptor that mediates their transport into neurons. METHODS. Gene and protein expression were analyzed in retinas of rd1 and rds mice and in those of RCS (Royal College of Surgeons) rats of various ages. Glial cell markers (cellular retina