Introduction of new myeloma therapies offers new options for patients refractory to immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). In this multicenter study, patients with relapsed multiple myeloma, who have received at least three prior lines of therapy, are refractory to both an IMiD (lenalidomide or pomalidomide) and a PI (bortezomib or carfilzomib), and have been exposed to an

Catharina Stenqvist (1950–2014) verkade som religionsfilosof med intresse för frågor om religiös erfarenhet och människans existentiella villkor. Hennes forskning kretsade kring mystik och mening och hon argumenterade för vikten att tala om livshållning snarare än livsåskådning. I föreliggande essä läser Patrik Fridlund en kort och lite annorlunda text av henne. I sitt efterord till denna essä skr

Tools for sound synthesis and acoustic analysis. Performs parametric synthesis of sounds with harmonic and noise components such as animal vocalizations or human voice. Also includes tools for spectral analysis, pitch tracking, audio segmentation, self-similarity matrices, and morphing.

Almost since the birth of electronic music, composers have been fascinated by the prospect of integrating the human voice with its expressiveness and complexity into electronic musical works. This thesis addresses how performing with responsive technologies in mixed works, i.e. works that combine an acoustic sound source with a digital one, is experienced by participating singers,adopting an appro

Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). Aims. In order to test these first parallax measurements of the primary standard candles of the cosmological distance ladder, which involve astrom

Background: Periarticular osteopenia is an early sign of incipient joint injury in rheumatoid arthritis (RA), but cannot be accurately quantified using conventional radiography. Digital X-ray radiogrammetry (DXR) is a computerized technique to estimate bone mineral density (BMD) from hand radiographs. The aim of this study was to evaluate whether decrease in BMD of the hands (BMD loss), as determi

The choice of milling cutter geometry and appropriate cutting data for certain milling application is of vital importance for successful machining results. Unfavorable selection of cutting conditions might give rise to high load impacts that cause severe cutting edge damage. Under some circumstances the radial depth of cut in combination with milling cutter geometry might give unfavorable entry co

Exchange of arguments in a discussion often makes individuals more radical about their initial opinion. This phenomenon is known as Group-induced Attitude Polarization. A byproduct of it are bipolarization effects, where the distance between the attitudes of two groups of individuals increases after the discussion. This paper is a first attempt to analyse the building blocks of information exchang

We study several problems of clearing subgraphs by mobile agents in digraphs. The agents can move only along directed walks of a digraph and, depending on the variant, their initial positions may be pre-specified. In general, for a given subset S of vertices of a digraph D and a positive integer k, the objective is to determine whether there is a subgraph H = (VH, AH) of D such that (a) S ⊆ VH, (b

Two approaches to the macro basis function (MBF) method that target interconnected subdomains have been adapted to finite linear arrays, and benchmarked against each other in order to estimate their performance with respect to the strong near field coupling that occurs under the endfire mode operation. The methods, here referred to as methods A and B, are based on the synthetic function and charac

The evolution of phenotypic plasticity requires a number of conditions. Selection of plasticity is favoured when the organism experience environmental change, costs are low and cues are reliable about the environmental heterogeneity. However, organisms living in stable environments, not showing constitutive traits but a large amount of plasticity, are predicted to demonstrate high rates of gene fl

What can be done to raise awareness of the significance of sense- and soundscape for health, wellbeing and communication? A massive body of research is being conducted in the sound environment field today with important discoveries especially on relationship between noise and health. Outcomes of this research slowly pours up into society, raising warnings of health and environmental risks, not sel