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BACKGROUND.: The proliferation signal inhibitor everolimus offers the potential to reduce calcineurin inhibitor (CNI) exposure and alleviate CNI-related nephrotoxicity. Randomized trials in maintenance thoracic transplant patients are lacking. METHODS.: In a 12-month, open-labeled, multicenter study, maintenance thoracic transplant patients (glomerular filtration rate >/=20 mL/min/1.73m and <90 mL
Normvärdet 0,5 luftomsättningar per timme är för lågt under den varma årstiden och onödigt hög på vintern. Ventilationen bör variera med årstiden. Helst bör styrningen ske automatiskt via ånghalten i luften. Rekommendationerna i SBN och nuvarande Nybyggnadsregler om hur platta på mark bör utföras har varierat under åren. Men konsekvent har man prioriterat uttorkning av byggfukt och därmed dragit
Symptom relief through spinal cord stimulation (SCS) based on the gate-control theory and enhanced external counterpulsation (EECP) through improved coronary perfusion is two treatments in angina pectoris refractory to medication and surgery. The overall aim was to evaluate and compare the initial and longterm effects, utilization and cost of EECP compared to SCS. The effects were also compared to
Progression to metastasis is the proximal cause of most cancer-related mortality. Yet much remains to be understood about what determines the spread of tumor cells. This paper describes a novel pathway in breast cancer that regulates epithelial-to-mesenchymal transition (EMT), motility, and invasiveness. We identify two transcription factors, nuclear factor 1-C2 (NF1-C2) and Forkhead box F1 (FoxF1
Poor nonword repetition is considered as a clinical marker of specific language impairment (SLI). In children with expressive language problems, the analysis and scoring procedures are often insufficiently described. We argue for a combined analysis of segmental and suprasegmental accuracy in nonword repetition tasks as well as an appreciation of gender differences. The view is taken based on empi
The production of municipal solid waste is one central concern for environmental policy, and the socio-materiality of waste – how the organisation of waste streams affects households and other waste producers – is an important issue for sustainability. This article shows how the application of European Union waste policy through its waste hierarchy affects the socio-material status of waste. The w
The aim of this study was to describe the everyday life experience of being an experienced active wheelchair user in Sweden.
Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both
En biografi över Christina och Carl Piper, deras liv och verksamhet.
If legal positivists wish to sustain their account of the international legal system, arguably, they have yet to explain how jus cogens obligations can derive from the usual norm-creating processes recognized by international law. This article provides such an explanation exactly. The explanation builds on the distinction between first order rules of jus cogens (commanding or prohibiting some cert
Kulturartikel om ett planerat svenskt projekt att skriva en ny svensk filmhistoria och en möjlig förebild i det amerikanska projektet History of the American Cinema på University of California Press.
Critical review of Caroline Ranby, "Skånes kyrkor. En kulturhistorisk resa genom 1000 år" (2014)
Enterohemorrhagic Escherichia coli (EHEC) infection leads to marked intestinal injury. Sigmoid colon obtained from two children during EHEC infection exhibited abundant TUNEL-positive cells. To define which bacterial virulence factors contribute to intestinal injury the presence of Shiga toxin-2 (Stx2), intimin and the type III secretion system were correlated with symptoms and intestinal damage.
Bone marrow sinusoidal endothelial cells have a specific function as a site of transmigration of hematopoietic stem and progenitor cells and mature blood cells between bone marrow and blood stream. However, the specific characteristics of bone marrow sinusoidal endothelial cells are still largely unclear. We here report that these cells express stabilin-1 and stabilin-2, which in liver sinusoidal
