Lipid nanoparticles of reversed internal phase structures, such as cubic micellar (I2) structure show good drug loading ability of peptides and proteins as well as some small molecules. Due to their controllable small size and inner morphology, such nanoparticles are suitable for drug delivery using several different administration routes, including intravenous, intramuscular and subcutaneous inje

Purpose: To compare clinicians and a trained artificial neural network (ANN) regarding accuracy and certainty of assessment of visual fields for the diagnosis of glaucoma. Methods: Thirty physicians with different levels of knowledge and experience in glaucoma management assessed 30-2 SITA Standard visual field printouts that included full Statpac information from 99 patients with glaucomatous

Feedforward control from measurable disturbances can significantly improve the performance in control loops. However, tuning rules for such controllers are scarce. In this paper design rules for how to choose optimal low-order feedforward controller parameter are presented. The parameters are chosen so that the integrated squared error, when the system is subject to a step disturbance, is minimize

La chimie des otolithes de poissons sert a associer les poissons a des environnements specifiques. La chimie des otolithes peut aussi potentiellement servir d'outil dans la recherche phylogenetique, comme nous le demontrons ici chez les poissons salmonides et les taxons apparentes. Des cartes bidimensionnelles de la chimie de Zn:Ca dans les otolithes montrent des oscillations annuelles d'amplitude

Packaging has a fundamental role in ensuring safe delivery of goods throughout supply chains to the end consumer in good condition. It also has great potential to contribute to sustainable development. This paper explores and provides insights on Swedish consumer perceptions and knowledge of environmental aspects of food packaging and elaborates on how these can contribute to or counteract environ

The therapeutic potential of baicalein against hepatoma cells was evaluated in vitro and in vivo. In cell viability assays, baicalein showed significant cytotoxicity against the hepatocellular carcinoma cell lines H22, Bel-7404, and Hep G2 and moderate cytotoxicity against immortalized human hepatocytes. Baicalein induced G0/G1-phase arrest in hepatocellular carcinoma cells, inhibited AKT, and pro

The recognition of carbohydrates by proteins is a fundamental aspect of communication within and between living cells. Understanding the molecular basis of carbohydrate-protein interactions is a prerequisite for the rational design of synthetic ligands. Here we report the high- to ultrahigh-resolution crystal structures of the carbohydrate recognition domain of galectin-3 (Gal3C) in the ligand-fre

Fast-track (FT) programmes are multimodal, evidence-based approaches to optimize patient outcome after surgery. The aim of this study was to evaluate the safety, clinical outcome and patients' experience of a FT programme after pancreaticoduodenectomy (PD) in a high-volume institution in Sweden.

Aim: To examine the incidence of post-lumbar puncture headache (PLPH) in patients admitted for cognitive disturbances. Methods: The incidence of PLPH and other general (subdural hematoma, meningitis, encephalitis) or local (local pain, spinal hematoma, local infection) complications was evaluated in 1,089 consecutive patients (aged 23-89 years) who underwent lumbar puncture as a part of the routin

To assess the association between diabetes family history and infant feeding patterns.

Our knowledge about males’ perceptions about causes of eating disorder is very limited, but can be useful in the treatment planning for males. The aim of this study was to describe how male former patients perceived causes of onset of their eating disorder. Fifteen males previously treated for eating disorders and now considering themselves as recovered where interviewed at ages 19 - 52. All inter

Branched endografts are a new option to treat arch aneurysm in high-risk patients.

The development of cellulose dissolution/regeneration strategies constitutes an increasingly active research field. These are fundamental aspects of many production processes and applications. A wide variety of suitable solvents for cellulose is already available. Nevertheless, most solvent systems have important limitations, and there is an intense activity in both industrial and academic researc

Abstract in UndeterminedA method for solving the change in capacitance (or charge) if an object is introduced in a parallel plate capacitor is developed. The integral representation of the potential is exploited in a systematic way to solve the potential everywhere inside the capacitor. In particular, the change in capacitance is extracted. The method shows similarities with the null field approac

The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e. g. osteoarthritis, OA). Responses of chondrocytes to tissue loading are modulated by the structure. Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis. To be able to evaluate cell responses and factors affecting the onset and prog