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Beijing has been experiencing severe particulate pollution accompanying the fast growing population and economy. This study investigated the impact of PM2.5 and its water soluble organic and inorganic constituents on visual impairment in Beijing under different meteorological conditions. According to the analysis of PM2.5 samples collected in Spring 2012, water soluble species took up 38.1% of PM2
Primary immunodeficiencies (IDs) are caused by inherited genetic defects leading to intrinsic defects in cells of the immune systems. Most IDs are rare diseases and can be difficult to diagnose because similar symptoms characterize several disorders. Mutation detection is the most reliable method in such cases. These tests are not available at most centers and physicians can have difficulties in f
Homeodomains are one of the key families of eukaryotic DNA-binding motifs and provide an important model system for DNA recognition. We have determined a high-quality nuclear magnetic resonance (NMR) structure of the DNA-binding homeodomain of the insulin gene enhancer protein Isl-1 (Isl-1-HD). It forms the first solution structure of a homeodomain from the LIM family. It contains a well-defined i
Millimeter-Wave (mmWave) massive multiple-input multiple-output (MIMO) has been considered as a key enabler for the fifth-generation (5G) communications. It is essential to design and test mmWave 5G devices under various realisticscenarios since the radio propagation channels pose intrinsic limitations on the performance. This requires emulating realistic dynamic mmWave channels in a reproducible
Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term
In this study an algorithm was developed for calculating maximum detectable distance (MDD) for mobile gamma-ray detection of lost sources in-situ for some common mobile spectrometer systems and gamma sources (137Cs and 60Co). The MDD is a function of detector efficiency, vehicle speed, acquisition time interval, radiation background level and accepted frequency of false alarms. To test its accurac
Bio-based 5-hydroxymethylfurfural (HMF) serves as an important platform for several chemicals, among which 2,5-furan dicarboxylic acid (FDCA) has attracted considerable interest as a monomer for the production of polyethylene furanoate (PEF), a potential alternative for fossil-based polyethylene terephthalate (PET). This study is based on the HMF oxidizing activity shown by Mycobacterium sp. MS 16
The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 outbreak on pediatric transplant activity and healthcare practices in both solid o
We analyze the size evolution of pebbles accreted into the gaseous envelope of a protoplanet growing in a protoplanetary disk, taking into account collisions driven by the relative sedimentation speed as well as the convective gas motion. Using a simple estimate of the convective gas speed based on the pebble accretion luminosity, we find that the speed of the convective gas is higher than the sed
The ability of the total extract from Physalis angulata; three fractions after partitioning with n-hexane, ethyl acetate (TBE), and water; and four withanolides (compounds 1 – 4) to phosphorylate 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells was evaluated. The TBE fraction (50 μg/mL) activated p-ACC and p-AMPK expression most strongly. C
With the increasing global awareness about the impacts of climate change on the built environments, the need for improving the climate resilience of buildings is being more acknowledged. Despite the high number of relevant studies, there is a lack of frameworks to assess the resiliency of buildings and urban areas. This study presents a multi-objective framework to optimize the form of buildings a
Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four souther
We exhibit families of 4-CNF formulas over n variables that have sums-of-squares (SOS) proofs of unsatisfiability of degree (a.k.a. rank) d but require SOS proofs of size nΩ ( d ) for values of d = d(n) from constant all the way up to nδ for some universal constant δ. This shows that the nO ( d ) running time obtained by using the Lasserre semidefini
A 27-47-GHz differential cascode power amplifier for millimeter-wave 5G new radio applications is presented. The PA is a three-stage design using inductively coupled impedance transformers with 31-dB nominal power gain. A device periphery ratio of 1:2:6 is adopted for predriver, driver, and final stage, respectively. A gain equalization technique was used in the interstage transformers to obtain t
The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES an
