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Plant major intrinsic proteins - functional implications of expression and localisation studies

Popular Abstract in Swedish Vattentransporten i växter är viktig för en mängd olika processer. De flesta fritidsodlare vet att vattentillgången påverkar växternas utveckling i stor utsträckning. För att solros ska kunna gro, växa, vända sig mot solen och bilda nya frön, behöver vatten flöda på ett kontrollerat sätt genom olika celltyper i växten. Växter transporterar vatten på olika sätt. Över lånPlant water channels are members of the very old Major Intrinsic Protein (MIP) family, with representatives in bacteria, fungi, animals, and plants. The genome of the model plant Arabidopsis thaliana contains 35 MIP genes. Based on protein sequence comparisons, the MIP family has been divided in four subfamilies: the PIP (Plasma membrane Intrinsic Protein), the TIP (Tonoplast Intrinsic Protein), t

Characterization of a novel brain barrier ex vivo insect-based P-glycoprotein screening model.

In earlier studies insects were proposed as suitable models for vertebrate blood-brain barrier (BBB) permeability prediction and useful in early drug discovery. Here we provide transcriptome and functional data demonstrating the presence of a P-glycoprotein (Pgp) efflux transporter in the brain barrier of the desert locust (Schistocerca gregaria). In an in vivo study on the locust, we found an inc

Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population.

Objectives. The aim of this study was to confirm the implication of macrophage migration inhibitory factor (MIF) gene in SSc susceptibility or clinical phenotypes in a large European population.Methods. A total of 3800 SSc patients and 4282 healthy controls of white Caucasian ancestry from eight different European countries were included in the study. The MIF -173 single nucleotide polymorphism (S

Kissingstents in the Aortic Bifurcation - a Valid Reconstruction for Aorto-iliac Occlusive Disease.

OBJECTIVE: To evaluate outcome and patency predicting factors of kissingstent treatment for aorto iliac occlusive disease (AIOD). METHODS: Patients treated with kissingstents for AOID between 1995 and 2004 at a tertiary referral center were identified through local databases. Chart review and preoperative images were used for TASC and Fontaine classification. Follow-up consisted of clinical exams,

Phenotypes in Defined Genotypes Including Siblings with Usher Syndrome.

Objective: To characterize visual function in defined genotypes including siblings with Usher syndrome. Methods: Thirteen patients with phenotypically different subtypes of Usher syndrome, including 3 families with affected siblings, were selected. Genetic analysis and ophthalmological examinations including visual fields, full-field electroretinography (ERG), multifocal electroretinography (mf ER

Antibiotic prophylaxis in oral healthcare - the agreement between Swedish recommendations and evidence.

BACKGROUND: Almost all (17/20) Swedish counties have pharmaceutical committees that establish recommendations for the use of antibiotic prophylaxis in oral healthcare.Objective To evaluate the evidence for the use of antibiotic prophylaxis in oral healthcare and the agreement between Swedish recommendations and evidence. MATERIAL AND METHODS: We conducted a systematic literature search in PubMed a

Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke.

Apolipoprotein E (ApoE), a cholesterol transporter and an immunomodulator, is brain protective after experimental stroke and implicated in brain repair. Here, we study the involvement of ApoE in the restoration of brain function after experimental stroke, by using animal housing conditions that differentially improve recovery after occlusion of the middle cerebral artery occlusion (MCAO). We found

Survival in cancer patients with previous hospitalization for sarcoidosis: a Swedish population-based cohort study during 1964-2006.

BACKGROUND: Sarcoidosis has been reported to be associated with an increased risk of cancer; however, little information is available about the prognosis for sarcoidosis patients diagnosed with cancer. PATIENTS AND METHODS: A population-based cohort of sarcoidosis patients was identified from Swedish registers. Cause-specific and overall hazard ratios (HRs) were estimated by using Cox regression m

Decoupling of multiple antennas in terminals with chassis excitation using polarization diversity, angle diversity and current control

Excitation of the chassis enables single-antenna terminals to achieve good bandwidth and radiation performance, due to the entire chassis being utilized as the main radiator. In contrast, the same chassis excitation phenomenon complicates the design of multiple antennas for MIMO applications, since the same characteristic mode of the chassis may be effectively excited by more than one antenna, lea

Scale-up of pervaporation for the recovery of natural aroma compounds in the food industry Part 2: optimisation and integration

In this study the integration and optimisation of hydrophobic pervaporation for the recovery of natural aroma compounds in the food industry has been studied. The simulation developed in the first part of this study was applied to the design and scale-up of pervaporation units for the recovery of natural apple juice aroma. Both semi-batch and continuous process configurations were considered and t

Geographical variation in incidence of prostate cancer in Sweden - Survey from the National Prostate Cancer Register

Objective. To investigate the geographical variation in prostate cancer incidence in Sweden, in particular the incidences of screening-detected tumours and curative treatment of prostate cancer. Material and methods. Data were retrieved from the National Prostate Cancer Register of Sweden for all cases of prostate cancer diagnosed in the year 2000-01. There were a total of 14 376 cases of prostate

Lexical and Acoustic Modelling of Swedish Prosody

Popular Abstract in Swedish Prosodi och intonation är viktiga delar i det mänskliga talet. I system för text-till-talomvandling och automatisk taligenkänning måste prosodiska modeller inkluderas för att uppnå acceptabla resultat. Denna avhandling bidrar till modelleringen av svensk prosodi ur lexikalt och akustiskt perspektiv. Tre aspekter av lexikal modellering av prosodi studeras. Vi skisserar Prosody and intonation are very important ingredients of human speech. In speech technology, text-to-speech (TTS) and automatic speech recognition (ASR) systems must incorporate prosodic models in order to reach acceptable performances. We contribute to the modelling of Swedish prosody in a speech technology context from lexical and acoustic angles. Three aspects of lexical prosodic modelling are

Non-germ-line encoded residues are critical for effective antibody recognition of a poorly immunogenic neutralization epitope on glycoprotein B of human cytomegalovirus.

The capability of the antibody (Ab) repertoire to mount a response to appropriate epitopes on infectious agents will strongly affect the ability of the immune system to provide protection against disease. Certain epitopes may be poor inducers of immunity but are nevertheless able to promote biologically important protection when recognized by the immune repertoire. We have investigated the recogni

Riboflavin and Ultraviolet A Collagen Crosslinking of the Cornea for the Treatment of Keratitis.

PURPOSE:: To describe riboflavin and ultraviolet light (UV) collagen crosslinking as an effective treatment for infectious keratitis. METHODS:: A 25-year-old previously healthy female contact lens user was diagnosed with unilateral severe keratitis with unclear pathogenesis, although the clinical presentation suggested acanthamoeba as the infectious agent. A 4-mm diameter, annular, semi-opaque inf

Convective vaporization in micro-fin tubes of different geometries

An experimental investigation was performed for convective vaporization of R22 and R410A inside one smooth tube and five micro-fin tubes with the same outer diameter of 5 mm. Data are for mass fluxes ranging from 100 to 620 kg/m2 s at 279 K saturation temperature. The results suggest that the tube with fin height of 0.15 mm, apex angle of 25° and 38° starts has the best thermal performance for con

Absolute Risk Reductions for Local Recurrence After Postoperative Radiotherapy After Sector Resection for Ductal Carcinoma In Situ of the Breast.

PURPOSE: Evaluate the effects of radiotherapy after sector resection for ductal carcinoma in situ of the breast (DCIS) in patient groups as defined by age, size of the lesion, focality, completeness of excision and mode of detection. PATIENTS AND METHODS: A total of 1,067 women in Sweden were randomly assigned to either postoperative radiotherapy (RT) or control from 1987 to 1999, and 1,046 were f

Renal effects of aspirin are clearly dose-dependent and are of clinical importance from a dose of 160 mg.

BACKGROUND: High doses of aspirin counteract the beneficial effects of angiotensin-converting enzyme (ACE) inhibitors. It is not known how low-dose aspirin, with concomitant ACE-inhibitor treatment, affects renal function. AIM: To study renal effects of different doses of aspirin in elderly healthy volunteers who had an activated renin-angiotensin system. METHODS: Sixteen subjects each received tw

Impact of exercise intensity and duration on insulin sensitivity in women with T2D.

BACKGROUND: Clinical guidelines seldom provide in depth information about the most suitable type and intensity of exercise to obtain optimal benefit in different subgroups of T2D individuals. The aim of this study was to examine the effect of group exercise training on exercise capacity, insulin sensitivity and HbA1c in women with diabetes. METHODS: Twenty-two women with T2D participated in a supe