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Background: Patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HCT) often face complex and evolving needs throughout recovery. Person-centred nursing (PCN) is essential in this context yet remains underexplored in specialised care settings. In Sweden, the Assessment of Rehabilitation Needs Checklist (ARNC) is commonly used in cancer care, but its role in supporting perso
Background: Current guidelines for the treatment of severe TBI recommend maintaining a cerebral perfusion pressure (CPP) at 60–70 mmHg. In our institution, as well as others, an alternative algorithm—originally named the Lund concept—has been used. This treatment algorithm employs metoprolol and clonidine to limit CPP, accepting levels below 60 mmHg, with the aim of reducing cerebral edema. Previo
Background Parathyroid surgery is an appropriate alternative for renal hyperparathyroidism (rHPT) in patients in whom medical therapy fails. European morbidity and outcome data for clearly defined cohorts, potentially reflecting contemporary clinical practice, remain scarce. Method Data were extracted from the EUROCRINE® database on all operations for secondary rHPT between 1 January 2015 and 31 D
Globally, suicide is a leading cause of mortality among teenage children and adolescents. Alcohol and other substances of abuse may influence both the decision to commit suicide and the choice of method. However, only few studies focused on toxicological findings in child suicides. The aim of this study was to map postmortem toxicological findings in child suicides in Sweden. Data on age, sex, sui
The IELSG37 trial enrolled 545 patients with primary mediastinal B-cell lymphoma (PMBCL) and demonstrated that consolidation radiotherapy (RT) can be omitted in patients with complete metabolic response, defined by the Lugano classification as Deauville score (DS) 1 to 3. This report evaluates outcomes after different frontline rituximab- and doxorubicin-based immunochemotherapy regimens chosen ac
Lung function monitoring and prompt diagnosis of lung impairment are essential for optimal patient care. During surgery, anesthesia and ventilator assistance are standard, and mechanical ventilation is often required in severe cases, as highlighted during the recent COVID-19 pandemic. There is a clear need for powerful, real-time lung surveillance techniques that can provide feedback to ventilator
Objectives: To assess the existence of international, scientifically validated methods for manual surgical skills training and assessment. The aim was to create a descriptive chronological summary of the existing evidence and conclusions in the included articles. Methods: PubMed and Scopus were searched twice for reviews published between 1997 and October 2023 and between 1997 and January 2024. Th
In primary Sjögren's disease (pSjD), there is a well-documented increased risk of hematological malignancies, particularly lymphomas, whereas studies examining the incidence of solid tumors have often yielded conflicting results. Data concerning the incidence of breast and gynecological cancers are similarly inconsistent. The aim of this study was to further investigate the incidence of these so-c
OBJECTIVE: To describe the distribution of HIV-1 variants in population-based national surveys conducted in sub-Saharan African countries between 2015 and 2022.DESIGN: Multicountry analysis.METHODS: Sixteen population-based national surveys, conducted between 2015 and 2022, were analyzed. Survey participants were eligible if HIV genotyping was successful. In most countries, people with HIV (PWH) w
Background Approximately one-third-of patients with transient new-onset atrial fibrillation (AF) during hospitalization for noncardiac surgery or medical illness will have recurrent AF within 1 year when assessed using two 14-day ECG monitors. The proportion of patients that would be diagnosed with recurrent AF with less monitoring is unknown. Methods We used data from a prospective cohort of part
Background: Laparoscopic cholecystectomy (LC) is performed by surgeons from various specialties and remains central to minimally invasive surgical training. This study assessed whether surgeon subspecialty affects patient outcomes and explored aspects of LC education. Methods: This population-based study included 46,700 LCs performed between 2020 and 2023, using data from the Swedish Registry for
Diffuse nitrate pollution remains a persistent threat to drinking-water resources, yet current predictive frameworks rarely capture how the spatial composition (land-cover fractions) and configuration (landscape fragmentation) of land systems jointly modulate leaching. This study presents a novel multiscale framework integrating hydro-climatic, soil and anthropogenic predictors with land-cover fra
Polyphagy is an adaptative strategy allowing species to develop and survive on multiple diets. Phytophagous insects can be exposed to sub-optimal resources, as host plants vary in nutritional quality. Some insects may rely on symbiotic bacteria to better utilize less favorable substrates. The invasive fruit fly Drosophila suzukii is a highly successful pest worldwide. The use of ripening and ripe
Background: There is limited data on the organisation of paediatric echocardiography laboratories in Europe. Methods: A structured and approved questionnaire was circulated across all 95 Association for European Paediatric and Congenital Cardiology affiliated centres. The aims were to evaluate: (1) facilities in paediatric echocardiography laboratories across Europe, (2) accredited laboratories, (
CD40 is a member of the tumor necrosis factor receptor super-family and has been suggested to play a role in the metabolism of beta-amyloid (Abeta) in Alzheimer's disease (AD). However, the role of CD40-signalling in incipient AD has not yet been studied. We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand (sCD40L) at baseline in 136 subjects with mild cognitive i
BACKGROUND: The method of treatment of aortic valve stenosis in early infancy is still controversial. This study was performed to evaluate short-term and long-term outcome in our center during a 14-year period.METHODS: Between 1991 and 2004, 64 consecutive patients younger than 3 months old underwent open surgical commissurotomy because of aortic valve stenosis. Median age was 18 days (range, 1 to
BACKGROUND: Traditionally oocytes have been exposed to sperm overnight, for 16-20 h. This long period of co-incubation, however, has been shown to create problems with high levels of reactive oxygen species (ROS), which may affect embryo viability and cause hardening of the zona pellucida. Recently, a positive effect of reducing the co-incubation time to 90-120 min was reported. The objective of t
Objectives The aim of the present study was to test whether construction workers, who are known to have a relatively higher risk of cardiovascular disease (CVD), had higher concentrations of cortisol in saliva and a lower relative variability when compared with white-collar workers. Methods Data from two groups of male construction workers with physically demanding job assignments, with either reg
Telomerase activity has been suggested to be critically involved in hematopoietic stem cell (HSC) self-renewal. However, it has been unclear whether human HSCs have telomerase activity and how telomerase activity is regulated within the HSC and progenitor pool. Here, we isolated living cord-blood (CB) CD34+ cells with up-regulated human telomerase reverse transcriptase (hTERT) expression by using
