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Aims/hypothesis: Mutations in hepatic nuclear factor 1alpha cause a monogenic form of diabetes, maturity onset diabetes of the young type 3 (MODY3). Our aim was 1) to assess the uptake of genetic testing for MODY3 and to determine factors affecting it, and ( 2) to compare attitudes to predictive genetic testing between families with MODY3 and a previously studied group at risk of hereditary nonpol
The aim of this study was to evaluate the role of thromboxane A2 in bradykinin-induced airflow obstruction in guinea pig in vivo. Airway insufflation pressure (Pi) was measured to assess airflow obstruction and the thromboxane B2 (a stable metabolite of thromboxane A2) concentration in bronchoalveolar lavage fluid was determined by radioimmunoassay. The animals were pretreated with propranolol (1
Giant cell tumor of bone (GCTB) is a benign but locally aggressive tumor with metastatic potential. We performed cytogenetic analysis on 10 1 GCTB from 92 patients. Karyotypes were obtained from 95 tumors, 47 of which had clonal aberrations. The majority of the cytogenetically abnormal GCTB had multiple, up to 28 per tumor, clones. Clonal telomeric associations (tas) and other structural and numer
This study reports carbon and water fluxes between the land surface and atmosphere in eleven different ecosystems types in Sub-Saharan Africa, as measured using eddy covariance (EC) technology in the first two years of the CarboAfrica network operation. The ecosystems for which data were available ranged in mean annual rainfall from 320 mm (Sudan) to 1150 mm (Republic of Congo) and include a spect
Inflammatory challenges of the airway mucosa cause luminal entry of bulk plasma. Extravasation of plasma is well described but the routes for epithelial passage of plasma are largely unknown. Using colloidal gold (5 nm) as tracer we have now examined the fate of extravasated plasma in the airways. The tracer was given intravenously to anaesthetized, ovalbumin-sensitized guinea-pigs 2min prior to a
Understanding the reasons for nonparticipation in cancer screening may give clues about how to improve compliance. However, limited cooperation has hampered research on nonparticipant profiles. We took advantage of Sweden's comprehensive demographic and health care registers to investigate characteristics of all participants and nonparticipants in a pilot program for colorectal cancer screening wi
Popular Abstract in Swedish Urininkontinens är en utbredd folksjukdom och ett stort folkhälsoproblem. Omkring 500 000 människor i Sverige, mest kvinnor (2/3) är drabbade. Förekomsten av inkontinens ökar med stigande ålder. Ofrivilligt urinläckage orsakar många gånger både medicinska och sociala handikapp med minskad livskvalitet som följd. Undersökningar har visat att endast 25% av de inkontinentaDysfunction of the pelvic floor can lead to incontinence and different forms of lower urinary tract symptoms (LUTS). Urinary incontinence is a common problem and about 500 000 persons in Sweden, mostly (2/3) women, suffering from incontinence. The general aim of this thesis was to characterize the function and dysfunction of the pelvic floor muscles in healthy and incontinent women. Vaginal EMG, p
Popular Abstract in Swedish Samhällets stöd, service och vård till människor med psykiska funktionshinder har under de senaste decennierna genomgått stora förändringar. Det har skett en övergång från slutna till samhällsbaserade öppna vårdformer. De kraftiga nedskärningarna av den sjukhusbaserade psykiatriska vården har emellertid långt ifrån alltid ersatts med ett heltäckande och fungerande vård-
Context: Insulin resistance in skeletal muscle is a major risk factor for the development of type 2diabetes in women with polycystic ovary syndrome (PCOS). Despite this, the mechanisms underlyinginsulin resistance in PCOS are largely unknown.Objective: To investigate the genome-wide DNA methylation and gene expression patterns inskeletal muscle from women with PCOS and controls and relate them to
The purpose of this study was to evaluate the effects of two alternative chemotherapy regimes on the quality of life (QoL) of patients with advanced breast cancer. In a multicentre trial, 283 patients were randomised to receive either docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). QoL was assessed at baseline and before each treatment using the European Organization for Research
BACKGROUND: Historically, a reduced serum sodium concentration has been used to diagnose absorption of electrolyte-free irrigating fluid during transurethral resection of the prostate (TURP). In bipolar TURP, the irrigating solution contains electrolytes, thus invalidating the serum sodium method. In this study, we investigated whether glucose can be used to diagnose the absorption of irrigating f
Extensive areas of old forests have declined all over the temperate regions of Europe mainly due to extensive forestry. This is likely to have negative impact on bats that roost in trees, such as the western barbastelle Barbastella barbastellus. We investigated its selection of summer roosts in a commercially used landscape in southern Sweden. We captured and radio-tracked 14 bats and found 17 occ
OBJECTIVE: The aim of this study was to compare the prevalence of heart failure (HF) in relation to age, multimorbidity and socioeconomic status of primary healthcare centres in southern Sweden.DESIGN: A cross-sectional study.SETTING: The data were collected concerning diagnoses at each consultation in all primary healthcare centres and secondary healthcare in the southernmost county of Sweden at
An increasing proportion of penicillin-susceptible Staphylococcus aureus (PSSA) has been reported over the last years. The aim of this retrospective study was to compare penicillin G with cloxacillin in the treatment of PSSA bloodstream infections. The primary outcome was the mortality rate after 90 days and the secondary outcome was the development of treatment complications of varying severity.
Background: Increasing evidence suggests a link between type 1 diabetes (T1D) and intake of gluten, but no controlled trials have examined whether a gluten-free diet (GFD) has positive effects on glycemic control in children with T1D. Methods: We conducted a non-randomized feasibility study. Twenty-three children with newly diagnosed T1D were included and either followed a GFD (n = 14) or a normal
Microbial stoichiometry has become a key aspect in ecological research as shifts in microbial C:N, C:P and N:P ratios upon nutrient addition are presumed to give insight into relative nutrient limitations for soil microorganisms–with far-reaching implications for biogeochemical processes. However, this expectation has never been tested against direct methods of microbial growth responses to nutrie
Warmer or cooler spring in northern high latitudes will, for the most part, directly impact gross primary productivity (GPP) of ecosystems, but also carry consequences for the upcoming seasonal GPP. Spatiotemporal patterns of these legacy effects are still largely unknown but important for improving our understanding of how plant phenology is associated with vegetation dynamics. In this study, imp
It can be difficult to engage colleagues with the findings and recommendations of an externally-funded project, even when, or perhaps particularly when, it has major implications for institutional processes. The authors were involved with a large single-institution Higher Education change project that aimed to make the university more responsive to changes in curriculum needs, the student voice, e
The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (≥18 years) who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests to create a symptom-based model to estimate the individual probability of
