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INTRODUCTION: Anaemia in patients having surgery is associated with worse postoperative outcomes. Management with intravenous iron is an attractive therapeutic option, however, pre-operative intravenous iron administration is challenging. Evidence from interventional trials suggests that the greatest benefit is after hospital discharge. As anaemia is common after surgery, this meta-analysis aimed
Background: Bile leakage is a severe complication after cholecystectomy and is associated with an increased risk of morbidity and mortality. The aim of this study was to evaluate the incidence of bile leakage post-cholecystectomy and to identify potential risk factors and their association with changes in the incidence of bile leakage over time. Methods: Demographic and perioperative data of all p
INTRODUCTION: Intracranial haemorrhage (ICH) is the most serious complication in infants and children with severe congenital bleeding disorders causing substantial mortality and long-term neurological morbidity. The neonatal period carries the highest risk, particularly in severe haemophilia and rare factor deficiencies. We review the epidemiology, risk factors, prevention, recognition, management
PurposeTürkiye ranks among the highest in antibiotic consumption within OECD countries and faces growing challenges from multidrug-resistant uropathogens. Nationwide, resistance-guided treatment data remain scarce. The main objective of this work is to provide a comprehensive nationwide data on antibiotic resistance patterns among uropathogens to guide treatment options in urinary tract infections
OBJECTIVE: To assess structural changes at peripheral entheses and the association with spinal bone formation in patients with long-standing radiographic axial spondyloarthritis (r-axSpA) overall and stratified by sex. METHODS: Peripheral entheses were examined cross-sectionally using ultrasound (US) in patients fulfilling the modified New York criteria for ankylosing spondylitis (AS) and assessed
From the Wunderkammern of Renaissance Europe to the curated vaults of today’s natural history museums, millions of insect specimens have been preserved, capturing an irreplaceable chronicle of biodiversity, including lineages that are rare, highly specialized, or already extinct. Yet their fragility has historically constrained genomic inquiry. Here, we apply museomic methodology to a >40-year-old
Studying the full universe of nearly 390,000 French patents filed between 1791 and 1900, I show that the nineteenth-century gender patenting gap arose less at the patent office than through unequal access to practical knowledge, collaborators, and time across the life course. I identify 4,165 women inventors using gender-specific honorifics, classify patents with machine learning, reconstruct the
Background Severe exacerbations (SevEx), the typical endpoint when evaluating asthma therapies, may provide incomplete assessment, as it relies on patient perception of disease and physician action. CompEx, a composite outcome that includes SevEx and acute worsening events (AWEs) (evaluated from e-diary entries using deterioration in peak expiratory flow (PEF), reliever medication use and worsenin
BACKGROUND AND OBJECTIVES: – The prognosis for functional independence after aneurysmal subarachnoid hemorrhage (aSAH) relies largely on patients' initial clinical status, age, and extent of the bleeding. However, some patients have poor outcome despite initially being in good clinical condition. The aim of this study was to analyze factors related to unfavorable outcome in patients with good clin
Trauma-induced hemorrhagic shock (HS) plays a decisive role in the development of immune, coagulation, and organ dysfunction often resulting in a poor clinical outcome. Imbalanced complement activation is intricately associated with the molecular danger response and organ damage after HS. Thus, inhibition of the central complement component C3 as turnstile of both inflammation and coagulation is h
BACKGROUND AND AIM: Hepatorenal syndrome (HRS) occurs in about 20 % of patients with liver cirrhosis and ascites and is characterized by intensive renal vasoconstriction, low glomerular filtration rate but preserved tubular function and normal renal histology. The potential of terlipressin and albumin to reverse HRS after a time period of 14 days has already been shown. However, intravenous albumi
Background: Direct oral anticoagulants (DOACs) reduce the rate of thromboembolism in patients with atrial fibrillation but the benefits and risks in survivors of intracerebral haemorrhage are uncertain. We aimed to determine whether DOACs reduce the risk of ischaemic stroke without substantially increasing the risk of recurrent intracerebral haemorrhage. Methods: PRESTIGE-AF is a multicentre, open
Studies on mantle cell lymphoma (MCL) emphasize that patients with progression of disease (POD) ≤24 months have inferior prognosis compared to patients with later POD. This population-based study assessed the impact of POD on overall survival (OS) by timing of progression and first-line treatment. A total of 1186 MCL patients diagnosed 2006–2018 were identified in the Swedish lymphoma register. PO
Background: Employment rates are lower in adults with cerebral palsy (CP). Even though reduced manual ability is associated with limitations in daily activities, it is unclear whether employment rates are associated with manual ability in adults with CP. Objective: To analyze regular employment and employment rates (hours/week) in adults with CP and estimate their associations with manual ability
Background Colorectal cancer (CRC) remains a major global health challenge with high morbidity and mortality despite advances in detection and treatment. Dietary polyphenols are secondary metabolites widely found in plant-derived foods and beverages, and have gained attention for their potential in CRC prevention and therapy due to their diverse biological activities. Methods This review synthesiz
BACKGROUND: Chronic obstructive pulmonary disease (COPD) has many known dysregulated inflammatory proteins. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that sheds several proteins involved in COPD pathogenesis. The aim was to investigate ADAM17, its phosphorylated form (pADAM17) and its substrates in bronchoalveolar lavage (BAL) and blood from COPD and control subjects. METHODS:
Bakgrund: Ett mått på följsamhet till paleolitisk kost som inte baseras på populationsrelativa intag av livsmedelsgrupper har hittills saknats. Syftet med denna avhandling var att utvärdera användbarheten av Paleolithic Diet Fraction (PDF), ett nytt mått på följsamhet till paleolitisk kost, beräknat som andelen av det totala intaget av livsmedelsgrupper som utgörs av paleolitiska livsmedelsgrupperAbstract: Background: A measure of adherence to the Paleolithic diet not based on population-relative food group intakes was lacking. The aim of this thesis was to evaluate the usefulness of the Paleolithic Diet Fraction (PDF), a novel measure of adherence to the Paleolithic diet, calculated as the fraction of total food group intake derived from Paleolithic food groups. Methods: PDF was calculate
Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children
Epilepsy is a prevalent neurological disorder characterized by spontaneous recurrent seizures (SRS). Epileptogenesis is a multifaceted pathophysiological process that transforms a normal brain into one prone to chronic seizures. Targeting epileptogenesis is a compelling line of epilepsy therapy. Thus, discovering new drugs that oppose, mitigate, or modify epileptogenesis is a significant challenge
Background: Studies in breast cancer patients have consistently shown that physical activity improves survival. We examined if change in physical activity from before to after a breast cancer diagnosis is associated with outpatient specialist care use and hospitalisations in women with type 2 diabetes mellitus (T2DM). Methods: This register-based cohort study included 2145 women with T2DM who self
