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Background: Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy (PD). DGE causes prolonged hospital stay and a decrease in quality of life. This study analyzes predictive factors for development of DGE after PD, also in the absence of surgical complications. Method: Data from the Swedish National Pancreatic Cancer Registry for patients undergoing standard and pyloru

OBJECTIVE: Determine whether there is a relationship between the number of different lower-limb resistance exercises prescribed in a program and outcomes for people with knee osteoarthritis.METHODS: Systematic review with meta-regression. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase up to 4th January 2024. We included randomised controlled trials th

Purpose: We aimed at analysing the risk of congestive heart failure (CHF) among first- and second-generation immigrants in younger age groups. Methods: All individuals aged 18–54 years, n = 3 973 454 in the first-generation study and n = 3 817 560 in the second-generation study, were included. CHF was defined as at least one registered diagnosis in the National Patient Register between 1 January 1

Neuroendocrine tumours (NETs) of the small intestine (siNET) are slow-growing malignancies often diagnosed at an advanced stage. Despite their indolent nature, patients frequently experience significant symptoms, including carcinoid syndrome (CS) with diarrhoea, which impact their health-related quality of life (HRQoL). This thesis investigates the determinants of HRQoL in siNET patients, its prog

BACKGROUND: Individuals with neovascular age-related macular degeneration (AMD) have altered number and distribution of retinal macrophages and show changes in circulating antibodies. We wanted to investigate the corresponding precursors, with subpopulations. We therefore measured monocyte and B-lymphocyte populations in individuals with neovascular AMD.DESIGN: This was an observational case-contr

Introduction: Cardiotomy suction blood is used in cardiopulmonary bypass (CPB) surgery to maintain blood volume in the CPB system, although it is known to contain micro emboli, cytokines and free plasma hemoglobin. Our aim was to investigate whether cell saver washing the cardiotomy suction blood before re-transfusing it is safe. Methods: This is a retrospective study of 1671 elective coronary art

BACKGROUND: Serious illness communication is a key element of high-quality care, but it is difficult to implement in practice. The Serious Illness Care Program (SICP) is a multifaceted intervention that contributes to more, earlier, and better serious illness conversations and improved patient outcomes. This qualitative study examined the organizational and implementation factors that influenced i

Background: Patients with relapsing remitting multiple sclerosis (RRMS) treated with the high-efficacy drugs natalizumab (NTZ) or rituximab (RTX) generally show no evidence of disease activity. Currently, there is no head-to-head comparison between NTZ and RTX of neurodegenerative and neuroinflammatory biomarkers in cerebrospinal fluid (CSF). Objectives: To compare CSF biomarkers in a stable RRMS

Due to the large-scale production of lignin, continuous flow reactors are preferred for its further valorization through depolymerization. However, there is limited literature on their use in lignin depolymerization, especially concerning feedstock pretreatments and catalyst deactivation. Therefore, in this study, the impact of a batch solvolysis pretreatment on the mild reductive catalytic depoly

Global warming has greatly stimulated vegetation growth through both extending the growing season and promoting photosynthesis in the Northern Hemisphere (NH). Analyzing the combined dynamics of such trends can potentially improve our current understanding on changes in vegetation functioning and the complex relationship between anthropogenic and climatic drivers. This study aims to analyze the re

Background: Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway inflammation and thus the development of COPD; while the absense of such upregulation would over time lead to chronic inflammation and COPD. We hypothesized that—among COPD patients—t

Objective: Following the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden. Methods: All patients with sp

Background: There are differences in oesophageal cancer care across Sweden. According to national guidelines, all patients should be offered equal care, planned and administrated by regional multidisciplinary team meetings. The aim of the study was to investigate differences between regional multidisciplinary team meetings in Sweden regarding clinical staging and treatment recommendations for oeso

Background: Middle Eastern (ME) immigrants to Europe have a heavy burden of metabolic disorders including a higher prevalence of insulin resistance, T2D and obesity as compared to native-born Europeans. Vitamin D insufficiency and deficiency are prevalent conditions in people originating from the ME. Aims: To study the differences in the levels of 25(OH)D and parathyroid hormone (PTH) across ME an

The Cretaceous–Palaeogene (K–Pg) mass extinction about 66 Ma ago was one of Earth’s largest mass extinction events. The demise of calcifiers, among others, influenced biogeochemical cycles and changed the conditions for carbonate depo sition in the global ocean. This study addresses the sedimentology and carbonate microfacies of the Cerithium Limestone Member of the Rødvig Formation within the ren

In the CONVINCE trial, the primary analysis demonstrated a survival benefit for patients receiving high-dose hemodiafiltration (HDF) as compared with high-flux hemodialysis (HD). A secondary objective was to evaluate effects on health-related quality of life (HRQoL); assessed in eight domains (physical function, cognitive function, fatigue, sleep disturbance, anxiety, depression, pain interference