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Background: We aimed to study the long-term effect of smoking on coronary atherosclerosis progression at the segmental level. Methods: Angiographic data (1989-2017) on current, former, and nonsmokers were collected from the Swedish Coronary Angiography and Angioplasty Registry. The Western Denmark Heart Registry was used to validate the results. Patients with clinically indicated angiography with
Jaboticaba (Plinia jaboticaba) is an underutilized Brazilian berry and a source of dietary fiber, cyanidin-3-O-glucoside, and ellagic acid derivatives. Non-clinical studies have shown the potential of jaboticaba to alleviate insulin resistance, low-grade inflammation, and obesity-related cognitive decline, although clinical evidence remains limited. A clinical study was conducted to investigate wh
BACKGROUND: Long COVID and cardiovascular autonomic dysfunction, including postural orthostatic tachycardia syndrome (POTS), present significant healthcare challenges. Long-term monitoring is challenging due to the evolving nature of symptoms and the limited availability of objective diagnostic tools. With over 200 million electrocardiogram (ECG)-enabled smartwatches sold worldwide, these devices
Background: The ability of modern ultrasound machines to detect signs of enthesitis has increased, yet there is a lack of studies on patients with long-standing radiographic axial spondyloarthritis (r-axSpA). Hence, we aimed to investigate the prevalence and clinical significance of Doppler signals indicative of inflammation in peripheral entheses of patients with long-standing disease. Methods: P
Background/Objectives: Intraoperative frozen biopsies are essential during surgery for Hirschsprung’s disease (HD). However, this method has several limitations with the need for a faster and real-time diagnostic alternative. For this, consistent histoanatomical and morphometric differences between aganglionic and ganglionic bowel must be established. The primary objective was to compare dimension
Background Olfactory dysfunction is a common non-motor symptom in Parkinson’s disease (PD). The objective was to evaluate the association between olfaction in PD with cross-sectional and longitudinal assessments of clinical variables and novel cerebrospinal fluid (CSF) markers. Methods Patients with PD and baseline olfactory function assessed using the Brief Smell Identification Test (B-SIT) were
Current electrode technologies are too rigid for safe and effective delivery of electrotherapy in the brain, and patients with glioblastoma continue to face a devastating prognosis, with median survival stalled at 15 months despite intensive treatment with surgery, radiation, and chemotherapy. But these conventional approaches potentially compromise immune function, underscoring the urgent need fo
Background: Peritoneal recurrence (PREC) following nephrectomy for localized renal cancer (RCC) is rare. Our objective was to report a multicenter analysis of PREC to analyze incidence, treatment, survival and risk factors. Methods: Between 1987 and 2023, patients with PREC following radical or partial nephrectomy (PN) for localized RCC across ten European institutions (UroCCR, NKI, IRCCS, Foch an
BACKGROUND: Child abuse continues to pose a significant threat to children's health. The repercussions of abuse are profound, impacting the child's physical, social, and emotional well-being, with potential long-term effects that may extend into adulthood. To assist in identifying health concerns in children associated with exposure to physical abuse, a health questionnaire was developed to be use
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has
Background There is limited knowledge on whether prior knee surgery impacts the clinical profile and treatment outcomes for individuals with knee osteoarthritis (OA). Objectives The study aimed to (i) compare individual and clinical characteristics, and (ii) evaluate whether outcomes of first-line treatment differ between individuals with prior knee surgery and those without. Methods This study us
Objective: To estimate the 12-year risk of radiographic and/or symptomatic knee osteoarthritis following different MRI-confirmed soft-tissue knee injuries. Design: Prospective cohort study including 814 (70 %) of 1129 consecutive patients after acute knee trauma with hemarthrosis in a single hospital. Injuries were classified by sub-acute knee MRI. Follow-up comprised bilateral knee radiography a
Despite significant progress in oncology research, pancreatic cancer remains inherently difficult to treat, and the mechanisms underlying therapeutic resistance remain unresolved. Decorin (DCN), a member of the family of small leucine-rich proteoglycans, has emerged as a versatile actor in various malignant diseases. The aim of this study was to further explore the potential clinical significance
Eddy covariance measurement of species that are co-emitted with carbon dioxide (CO2), such as carbon monoxide (CO) and nitrogen oxides NO and NO2 (NOx), provides an opportunity to attribute a net flux to individual source or sink categories. We present eight months of continuous simultaneous measurements of fluxes (F) of CO2, CO, NOx, methane (CH4), and nitrous oxide (N2O) from a tall tower (112 m
Objectives There is a lack of knowledge about whether occupational exposures increase the risk of emphysema, especially in never-smokers. Our objective was to determine if occupational exposures are associated with emphysema and impaired diffusing capacity. Methods In the Swedish CArdioPulmonary bioImage Study (SCAPIS), persons from the general population aged 50–64 answered a questionnaire and un
During graded exercise, systolic blood pressure (SBP) is expected to increase linearly, but other responses are observed. To date, a framework for algorithmic assessment of the shape of the SBP response is lacking, making its physiological and clinical relevance poorly understood. We aimed to algorithmically identify distinct SBP response shapes and analyze their association with clinical factors
