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Restarting anticoagulation early versus late in patients with chronic subdural hematoma and atrial fibrillation (RELACS) : a phase III international multicenter, randomized controlled, two-arm, assessor-blinded trial

Background: Chronic subdural hematoma (CSDH) is a rapidly growing neurosurgical condition, driven primarily by an aging population and the increasing use of antithrombotic medications. Approximately 25% of CSDH patients are on anticoagulants due to atrial fibrillation (AF). The postoperative management of these patients presents a significant clinical challenge, as clinicians must balance the risk

Investigation of methods for quantifying sitting postures in cars

Understanding and being able to quantify sitting postures is a central asset in car safety evaluations. This is due to the fact that passengers can choose a range of different sitting positions. Studying and understanding how passengers choose to sit to obtain some comfort is important for increased safety in futures cars and is particularly challenging facing a heterogeneous population. Data is a

Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study.

AIMS: Atrial fibrillation (AF) is a frequent co-morbidity in heart failure (HF) associated with increased mortality, but little is known about the mechanisms underlying AF onset in HF patients. We evaluated the association of cardiovascular and genetic risk factors with AF in HF patients. METHODS AND RESULTS: Individuals hospitalized for HF (n = 1040; 500 with AF) were identified from a large, pop

Can a "state of the art" chemistry transport model simulate Amazonian tropospheric chemistry?

We present an evaluation of a nested high-resolution Goddard Earth Observing System (GEOS)-Chem chemistry transport model simulation of tropospheric chemistry over tropical South America. The model has been constrained with two isoprene emission inventories: (1) the canopy-scale Model of Emissions of Gases and Aerosols from Nature (MEGAN) and (2) a leaf-scale algorithm coupled to the Lund-Potsdam-

Four decades of satellite observations reveal climate-driven shifts and spatial heterogeneity in shallow lake Chlorophyll-a dynamics

Shallow lakes worldwide face escalating pressures from eutrophication and climate change, yet comprehensive monitoring of Chlorophyll-a (Chl-a) spatiotemporal dynamics remains challenging due to the high costs and logistical constraints of traditional sampling approaches across large, heterogeneous water bodies. Lake Balaton, a large shallow lake system (80 km long, 7 km wide, 3.7 m mean depth) in

Motion and Eddy-Current Correction in Diffusion MRI

Subject motion and eddy-current distortions represent significant challenges in diffusion MRI, particularly for clinical protocols utilizing "half-sphere" sampling. While the current gold standard, FSL’s eddy, employs Gaussian Process (GP) predictions to correct these artifacts, its performance can degrade under specific acquisition constraints, most notably when sampling lacks antipodal

The micrometeorite flux in the Albian–Aptian age (ca. 103–117 Ma): A search for Tycho ejecta in pelagic sediments using chrome spinels

Numerical models of meteorite delivery from impacts on the Moon have demonstrated that the impact event forming the lunar crater Tycho (~85 km diameter; ca. 109 Ma age) would have delivered considerable amounts of ejected material to Earth. The ejecta, containing lunar Ti- and V-rich chrome spinels, would have been distributed globally and admixed with seafloor sediments over a few meters of a typ

Den allmänna rösträttens utveckling - En komparativ uppsats om kampen för allmän rösträtt i Sverige, USA och Storbritannien med särskilt fokus på kvinnlig rösträtt

Den allmänna rösträtten har genom historien varit något som människor be-hövt kämpa för. Idag kan man tycka att det ska vara en självklarhet att alla människor är berättigade lika och allmän rösträtt, men så har fallet långt ifrån alltid varit. Så sent som 1965 såg man till att alla svarta medborgare i USA tilläts utöva sin rätt att rösta. I Sverige, Storbritannien och USA finns det många likhetUniversal suffrage has throughout history been something people have had to fight for. Today, it may seem self-evident that all people are equally entitled to universal suffrage, but this has far from always been the case. As recently as 1965, measures were taken to ensure that all Black citizens in the United States were allowed to exercise their right to vote. In Sweden, Great Britain, and the

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease

Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous. Although biomarkers for amyloid-beta (Aβ) and tau proteins, the hallmark AD pathologies, have improved pathology-based diagnosis, they explain only 20–40% of the variance in AD-related cognitive impairment (CI). To discover novel biomarkers of CI in AD, we performed cerebrospinal fluid (CSF) proteomics on 3,397 ind

Harnessing the Generative AI Wave Towards Fair and Diverse Higher Education Assessments : A Comprehensive Analysis through an Innovative Lens of Students

While Generative Artificial Intelligence (GAI), particularly tools powered by Large Language Models (LLMs), offer benefits in teaching and learning, they also raise critical concerns about academic integrity, fairness in examinations d ue to their potential for generating educational content. This evolving landscape requires higher education institutions to rethink their assessment models, ensurin

A global map of groundwater-dependent vegetation in the Mediterranean biome

Groundwater-dependent vegetation (GDV) plays a vital role in maintaining biodiversity and ecosystem services in the Mediterranean biome but is increasingly threatened by climate and land use change. Large-scale GDV mapping in arid regions is critical for effective conservation and water resource management but remains challenging due to limited ground-truth data and the lack of high-resolution rem

Development of a Microfluidic DEP-enhanced DLD Method for Sorting Bone Marrow Adipocytes

Isolating fragile and heterogeneous cell populations from complex tissues remains a core challenge in biomedical research. In the bone marrow (BM), bone marrow adipocytes (BMAds) are key regulators of hematopoiesis and metabolism, yet their large size, fragility, and lack of specific surface markers have hindered their isolation using conventional methods such as fluorescence-activated cell sortin

Integrating Tumor-Intrinsic and Immunologic Factors to Identify Immunogenic Breast Cancers from a Low-Risk Cohort : Results from the Randomized SweBCG91RT Trial

PURPOSE: The local immune infiltrate's influence on tumor progression may be closely linked to tumor-intrinsic factors. The study aimed to investigate whether integrating immunologic and tumor-intrinsic factors can identify patients from a low-risk cohort who may be candidates for radiotherapy (RT) de-escalation.EXPERIMENTAL DESIGN: The SweBCG91RT trial included 1,178 patients with stage I to IIA

Toward Super-Resolution Reconstruction of Diffusion–Relaxation MRI Using Slice Excitation With Random Overlap (SERO)

Purpose: Diffusion MRI probes tissue microstructure, but low SNR and limited resolution hinder detection of features and parameter estimates. We introduce slice excitation with random overlap (SERO), which enables variable repetition times (TRs) and diffusion weighting within a single shot. This acquisition supports super-resolution reconstruction of baseline signal ((Formula presented.)), diffusi

Unlocking Creativity: Integrating Electronic Digital Instruments in Music Education

The EDI Guidelines (https://www.ediguidelines.se), an outcome of the Swedishgovernment funded practice-based school research project “The Digital Student -Challenges and Opportunities with the Computer as an Instrument in Music Education” (2021-2024), provide a valuable resource for integrating Electronic Digital Instruments (EDI) into music education in upper secondary school. This workshop is de

Plasma GDF-15 and PSP-D Predict the Development of Pulmonary Arterial Hypertension in Systemic Sclerosis

Patients with pulmonary arterial hypertension (PAH) experience long diagnostic delays, high functional class at diagnosis and poor prognosis. We aimed to study the differentiative and predictive value of 90 inflammatory and immunomodulatory related proteins in idiopathic and hereditary PAH (IPAH/HPAH) and systemic sclerosis-associated PAH (SSc-APAH). Cohort 1 comprised patients with SSc-APAH ( n =

Novel membrane processes for water treatment : From wastewater treatment to desalination and stormwater harvesting

Global water scarcity requires innovative treatment solutions. This presentation explores three membrane-based concepts advancing from idea to pilot scale: stormwater harvesting with micro-/ultrafiltration (MF/UF), direct membrane filtration (DMF) for wastewater treatment, and a hybrid forward osmosis (FO), membrane distillation (MD), and nanofiltration (NF) system for seawater desalination.The EU