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Background: Adolescent major depressive disorder (MDD) is highly prevalent and associated with lifelong adversity. Evidence-based treatments exist, but accessible treatment alternatives are needed. We aimed to compare internet-based psychodynamic therapy (IPDT) with an established evidence-based treatment (internet-based cognitive behavioural therapy [ICBT]) for the treatment of adolescents with d
STUDY QUESTION: Does previous bariatric surgery (BS) in women affect cumulative live birth rate in IVF?SUMMARY ANSWER: Women having had BS seem to have the same cumulative live birth rate as non-operated women of the same BMI at IVF treatment.WHAT IS KNOWN ALREADY: Because of the perinatal risks of obesity to mother and infant as well as impaired outcomes of IVF, obese women are advised to reduce
The increase of the consumer electronics market the last couple of decades has been one of the main drivers of IC process technology development. The majority of the ICs are used in digital applications, and for these CMOS is the choice of technology. The urge to squeeze more transistors on to a given area has led to shrinking feature sizes. It has resulted in higher transition frequencies and red
Background and objective: The pharmacokinetics of mycophenolic acid (MPA) are complex, with large interindividual variability over time. There are also well documented interactions with ciclosporin, and assessment of MPA exposure is therefore necessary when reducing or stopping ciclosporin therapy. Here we report on the pharmacokinetic and pharmacodynamic behaviour of MPA in renal transplant patie
Popular Abstract in Swedish Stroke, eller slaganfall, är en sammanfattande benämning på sjukdomar som drabbar blodförsörjningen i hjärnan. Varje år insjuknar cirka 30000 personer i Sverige i stroke, av dessa drabbas cirka 15% av blödningar medan resterande 85% får infarkter, dvs blodpropp i hjärnan. Stroke upptar fler vårddagar i slutenvården än någon annan somatisk sjukdom. Medianåldern för insjuBackground Stroke is a serious vascular disorder that comprises intracerebral hemorrhages, subarachnoid hemorrhages and ischemic stroke (IS). The etiology of stroke, including hereditary components induced by cellular mechanisms, is therefore a research field of vital importance. The aim of this thesis was to assess possible genetic impact on stroke risk. We thus evaluated family history of strok
Popular Abstract in Swedish Resultatet efter en höftprotesoperation är otvetydigt gott med smärtfrihet och god funktion ofta livet ut hos de flesta. 2012 opererades i Sverige cirka 16000 patienter med höftprotes och siffran stiger. 3-4% av patienterna drabbas av en proteslossning under de första tio åren och behöver opereras om, en så kallad revision. Den gamla protesen avlägsnas då och ersätts meThe clinical success of primary hip replacement is paramount but the need for revisions will continue to increase due to the increasing number of operated individuals. In Sweden, the number of hip revisions in 2012 exceeded 2,300. During implant loosening, some of the bone in the femur is lost, which can make the revision more difficult. One way of handling bone loss has been the impaction techniq
During the last decades the need to control the paper production process has grown, due to the technological development and the continuing increases in quality demands. Recent development of sensors and fast, high-capacity computers open up new possibilities for the development of high capacity monitoring systems for the paper industry. Optical methods have advantages for performing fast and high
As current silicon-based microelectronic devices and circuits are approaching their fundamental limits, the research field of nanoelectronics is emerging worldwide. With this background, the present thesis focuses on semiconductor nanoelectronic devices based on ballistic and quantum effects.
The main material studied was a modulation doped In0.75Ga0.25As/InP semiconductor two-dimensional el
Popular Abstract in Swedish Helicobacter pylori är en spiralformad Gramnegativ human-specifik patogen, som kan penetrera magsäckens slemlager och kolonisera epitelskiktet. H. pylori infektion är en högriskfaktor för utvecklandet av kronisk gastrit, magsår och ventrikelcancer. Både aktivt växande spiralformer av H. pylori och dess runda viloformer framkallar kronisk magkatarr (gastrit) i BALB/cA möHelicobacter pylori is a human pathogen strongly associated with chronic type B gastritis, peptic ulcer disease, gastric cancer and MALT lymphoma. Our aims were to establish a mouse model of H. pylori infection, to study pathogenesis of gastritis and gastric cancer and to investigate new treatment strategies in this model. Both spiral and coccoid forms of H. pylori strains 17874, 25 and 553/93 cau
Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association betwee
Contributions of changes in soil moisture to the projected climate change in the tropics at the end of the twenty first century are quantified using the simulations from five different global climate models, which contributed to the GLACE–CMIP5 experiment. “GLACE” refers to the Global Land Atmosphere Coupling Experiment and “CMIP5” to the fifth phase of the Coupled Model Intercomparison Project. T
Objective. To evaluate 10 biomarkers in magnetic resonance imaging (M RI)-determined, pre-radiographically defined osteoarthritis (pre-ROA) and radiographically defined OA (ROA) in a population-based cohort of subjects with symptomatic knee pain. Methods. Two hundred one white subjects with knee pain, ages 40-79 years, were classified into OA subgroups according to MRI-based cartilage (MRC) scores
1. The distribution of the carbon monoxide (CO) producing enzymes haem oxygenase (HO)-1 and -2 was studied by immunohistochemistry in the pig's lower urinary tract, including bladder extramural arteries, and the oesophagogastric junction (OGJ). In isolated smooth muscle from the urethra and the OGJ, the mechanisms for CO-induced relaxations were characterized by measurement of cyclic nucleotide le
Background Sick leave due to neck, shoulder and back disorders (NSBD) is higher among health-care workers, especially nursing aides/assistant nurses, compared with employees in other occupations. More information is needed about predictors of sick leave among health care workers. The aim of the study was to assess whether self-reported factors related to health, work and leisure time could predict
This study aimed to find out how the insulation of the footwear changes over one week of use. A thermal foot model with 8 measuring zones and 5 “sweat glands” was used for tests. A thin sock was donned on the model to allow better water distribution all over the foot surface. Four boots were tested over a period of 5 days. Each day was divided into 9 hour measurement period and 15 hour conditionin
Square-wave (SQW) ultraviolet-B (UV-B: 280–315 nm) radiation supplementation systems continue to be used in outdoor experimental locations due to the economically restrictive installation and maintenance costs, and technical expertise required to effectively operate more advanced modulated (MOD) delivery systems. However, continued yet contentious criticisms of SQW delivery systems risk creating p
Whether risk factors for epithelial ovarian cancer (EOC) differ by subtype (i.e., dualistic pathway of carcinogenesis, histologic subtype) is not well understood; however, data to date suggest risk factor differences. We examined associations between reproductive and hormone-related risk factors for EOC by subtype in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A
The purpose of this study was to evaluate 10 process-based terrestrial biosphere models that were used for the IPCC fifth Assessment Report. The simulated gross primary productivity (GPP) is compared with flux-tower-based estimates by Jung etal. [Journal of Geophysical Research 116 (2011) G00J07] (JU11). The net primary productivity (NPP) apparent sensitivity to climate variability and atmospheric
It is now becoming increasingly clear that free radicals contribute to brain damage in several conditions, such as hyperoxia and trauma. It has been more difficult to prove that free radical production mediates ischemic brain damage, but it has often been suggested that it may be a major contributor to reperfusion damage, observed following transient ischemia. Recent results demonstrate that cereb
Based on a large number of new boreholes in northern Denmark, and on the existing data, a revised event-stratigraphy is presented for southwestern Scandinavia. Five significant Late Saalian to Late Weichselian glacial events, each separated by periods of interglacial or interstadial marine or glaciolacustrine conditions, are identified in northern Denmark. The first glacial event is attributed to
