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Introduction: FLASH radiotherapy (RT) has emerged as a promising modality, demonstrating both a normal tissue sparing effect and anticancer efficacy. We have previously reported on the safety and efficacy of single fraction FLASH RT in the treatment of oral tumors in canine cancer patients, showing tumor response but also a risk of radiation-induced severe late adverse effects (osteoradionecrosis)
Background: Despite accumulating evidence of an association between air pollution and renal disease, studies on the association between long-term exposure to air pollution and renal function are still contradictory. This study aimed to investigate this association in a large population with relatively low exposure and with improved estimation of renal function as well as renal injury biomarkers. M
Context. White-light stellar flares are proxies for some of the most energetic types of flares, but their triggering mechanism is still poorly understood. As they are associated with strong X and ultraviolet emission, their study is particularly relevant to estimate the amount of high-energy irradiation onto the atmospheres of exoplanets, especially those in their stars’ habitable zone. Aims. We u
Background: International guidelines recommend placement of intrauterine devices immediately after second-trimester medical abortion, but evidence concerning the optimal time for intrauterine device placement is lacking from clinical trials. Objective: This study aimed to investigate effectiveness, safety, and acceptability of intrauterine device placement within 48 hours, compared with placement
Phosphoglucomutase-1-congenital disorder of glycosylation (PGM1-CDG) is a rare genetic disorder caused by biallelic variants in the PGM1 gene, leading to the deficiency of the PGM1 enzyme. The most common clinical presentations include muscle involvement, failure to thrive, cleft palate, and cardiac involvement. Abnormal serum N-glycosylation, hypoglycemia, and liver function abnormalities includi
Background: In recent years, fighting arts (e.g., Karate, Judo, Jujitsu, Boxe) have gained broader attention due to their multiple benefits, involving both physical and psychological enhancements for practitioners. Despite that, studies revolving around specific psychological characteristics such as personality traits are scarce. This study explored potential connections between the personality tr
Background: Single diffusion encoding is a widely used, noninvasive technique for probing the tissue microstructure in breast tumors. However, it does not provide detailed information about the microenvironmental complexity. This study investigated the clinical utility of tensor-valued diffusion encoding for evaluating microstructural changes in breast cancer after neoadjuvant chemotherapy (NAC).
Background: Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regard to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs),
Land cover governs the biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene temperature conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Prog
The rheological properties of bituminous binders tested with a dynamic shear rheometer (DSR) as a function of loading time and temperature can more accurately represent real road situations with rising traffic loads and densities combined with climatic change. This method is more effective than traditional methods such as measuring the softening point and penetration. Complex shear modulus and pha
Syftet med denna uppsats är att undersöka förslaget att införa en ny form av uppgiftsskyldighet, Mandatory Disclosure Rules, i skatteförfarandelagen. Förslaget består dels av en implementering av EU-direktivet DAC 6, dels av en inhemsk reglering som saknar motsvarighet i DAC 6. Det huvudsakliga syftet med förslaget är att motverka aggressiv skatteplanering. I uppsatsen används den rättsdogmatiska The purpose of this thesis is to review the proposal to introduce a new reporting obligation, Mandatory Disclosure Rules, in the Swedish Tax Procedures Act. The proposal consists partly of an implementation of the EU directive DAC 6, partly of a domestic regulation without parallel in DAC 6. The main purpose of the proposal is to counter aggressive tax planning. In the thesis, the traditional lega
The road 111 that runs past Helsingborg is an important connecting road to a larger road network for the towns and areas outside of Helsingborg. The purpose of this essay is to do a research to see whether a measure is needed from an accessibility perspective and to give a proposal for an appropriated measure. The analysis is limited to the distance between the traffic point Brohult and the exit p
Sverige är ett tämligen unikt land när det kommer till den offentliga förvaltningen. Regeringens underlydande myndigheter har lydnadsplikt, samtidigt som myndigheterna ska vara självständiga. Sverige har inget ministerstyre, utan det är regeringen som kollektivt kan ge direktiv till sina myndigheter. Uppsatsen ämne berör i vilken mån regeringen kan använda sig av så kallade informella kontakter, ”Sweden is a rather unique country when it comes to public administration. The government agencies must show obedience towards the government, but the government agencies are at the same time independent from the government. Sweden does not allow ministerial rule, instead the governmet is forced to give directives collectively. The main subject of the essay is to ascertain in what way the governmen
Den digitala utvecklingen har förändrat detaljhandelsbranschen i stor utsträckning. Priserna på e-handelsmarknaden är normalt sett lägre än priserna i fysiska butiker till följd av hård konkurrens, prismedvetna konsumenter och dynamisk prissättning (en prissättningsmodell som innebär att priserna på en produkt varierar flera gånger om dagen). Prismarknadsföring (realisationer, slutförsäljningar, uDigitalisation has had a significant impact on the retail industry. Due to strong competition, price-conscious consumers and dynamic pricing (a pricing strategy in which prices varies several times throughout the day) prices in E-commerce are usually lower than prices in traditional commerce. Under these circumstances, price reductions (sales, clearance sales and finale sales) and price comparison
Sammanfattning Instansordningsprincipen är en förvaltningsrättslig princip som huvudsakligen medför att parterna i ett förvaltningsmål är förhindrade att tillföra nytt processmaterial i högre instanser. Principen är, emellertid, inte uttryckligen lagstadgad i Förvaltningsprocesslagen (1971:291), FPL. Istället är det upp till förvaltningsdomstolarna att tolka de uttalande som finns i förarbetena tiSummary The principle of the court hierachy is a principle within administrative law whose intention is to prevent the parties to add new case material in the higher instances. The principle, however, is not explicitly stated in the Administrative Court Procedure Act (1971: 291), FPL. Instead, the administrative courts are given the task to interpret various statements contained in the legislative
Kiselalger, vattenlevande, mikroskopiska organismer med kiselskal, används som bioindikatorer för vattenkvalitet eftersom de är artrika och påverkas av sin omgivning. Processen kallas Kiselalgsmetoden och utförs genom en standard, en standard jag valde att analysera. Proven tas från stenar i vattendrag och sedan görs ett preparat som är fixerat på objektglas som kan undersökas i mikroskop genom aDiatoms, water living, microscopic organisms with silicon shells, are used as bioindicators of water quality because they are diverse and influenced by their surroundings. The process is called The Diatom Method and is accomplished through a standard, a standard I have chosen to analyze. The samples are taken from stones in water streams and then a preparation is made to fix the algae on slides t
The focus of this work is to investigate and apply the remote sensing method of object-based image analysis (OBIA) for vegetation classification of a permafrost underlain peatland in sub-arctic Sweden, by using aerial imagery of high resolution. Since the northern landscapes are an important source of naturally stored CH4 and CO2, their contribution to the global carbon cycle is a focus in researc
Denna uppsats tar sin utgångspunkt i den livliga debatt som har förts inom advokatsamfundet sedan april 2004 angående intressekonflikter. Bakgrunden är den att advokatsamfundet utfärdade ett vägledande uttalande som förbjöd representation av flera klienter vid en viss typ av köpeprocess av företag, kallad controlled auctions. Advokatsamfundet och flertalet svenska advokater hävdade att detta bara
Lagen om anställningsskydd infördes år 1974 för att trygga anställningen för alla enskilda arbetstagare på den svenska arbetsmarknaden. Tidigare hade arbetstagarnas rättigheter reglerats i kollektivavtal och endast vissa arbetstagares rättigheter var reglerade i lag. Några regler som infördes i 1974 års lag var bland annat saklig grund för uppsägning enigt 7 § LAS. För att saklig grund skulle anseThe Employment Protection Act from 1974 was implemented in to Swedish law as a way to secure the employments of the employees. Before the implementation of the Act, the rights of the employees were regulated in collective agreements. By then there were only some rights regulated in the law. Some of the regulations that were implemented in to the Employment Protection Act was the 7§. The 7 § states
The building industry accounts for a large part of the world’s carbon dioxide emissions. At the same time the awareness of sustainable construction and production phase has increased and focus has been directed towards the material wood. Likewise, continuing urbanisation requires multi-storey buildings made of wood which brings along certain difficulties and challenges. Due to the low mass of wood
