Sökresultat

Background: Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regard to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs),

Land cover governs the biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene temperature conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Prog

The rheological properties of bituminous binders tested with a dynamic shear rheometer (DSR) as a function of loading time and temperature can more accurately represent real road situations with rising traffic loads and densities combined with climatic change. This method is more effective than traditional methods such as measuring the softening point and penetration. Complex shear modulus and pha

Background: Dietary risks today constitute the largest proportion of disability-adjusted life years (DALYs) globally and in Sweden. An increasing number of people today consume highly processed foods high in saturated fat, refined sugar and salt and low in dietary fiber, vitamins and minerals. It is important that dietary trends over time are monitored to predict changes in disease risk. Methods:

Området som undersöktes i denna studie ligger i västra delen av Hamrångesynklinalen. I studien har bergarter, bergartsgränser och strukturer karterats i fält. Tunnslip undersöktes med optisk mikroskopi i avseende på petrografi och förekomst av mikrostrukturer. Flera av tunnslipen har punkträknats för bergartsklassificering. Några bergarter har Rietveldanalyserats för närmare bestämning av mineralsThe studied area is located in the western part of the Hamrånge syncline. In this area, the rocks, contacts and structures were mapped . Thinsections were investigated regarding petrography and microstructures, and representative thinsections were pointcounted. Three samples were selected for Rietveld analysis to receive the chemical compositions. Minerals from both the syncline and the area outsi

Introduction: This work aims to evaluate the possibility to transfer electrical power from a metal plate to the steel-cord within a car tire. If the tire stands on the plate, a connecting surface occurs which can be interpreted as a capacitor, where the rubber compound acts as a dielectric. Method: First the impedance of the tire is evaluated: An analytical model is set-up to describe the system;

Populärvetenskaplig sammanfattning: Drunkningsrisk för skogen? Att mängden vatten i marken är viktig för att granen ska kunna ha så god tillväxt som möjligt är ingen nyhet. Är det för fuktigt drunknar rötterna, på grund av att de inte får en tillräckligt mycket syre. I denna studie har två markberedningsmetoder, högläggning och ingen markberedning, jämförts för att se vilket alternativ som är mestNorway spruce is a coniferous tree with many different fields of application. For an example, they are used as Christmas trees, decoration and as timber or pulpwood. The reason why many foresters in Sweden tend to choose spruce as their main species for plantation is partly because of their fast growth rate and partly because the main products are derived from the actual tree trunks. In the forest

This paper analyses the causes and effects of tenure security in rural China. Using original survey data gathered in Hebei province in the summer of 2009, it begins by assessing the causes of tenure security among China’s rural landholders. It finds that within the sample, possession of a contract and faith in the legal system have the most pronounced effect on determining tenure security. Contrar

The subject of this thesis is theoretical examination of freezing phenomena inside fire sprinkler systems during activation at low temperatures in the surroundings. Many sprinkler systems are installed in environments such that they must be operable at subfreezing temperature conditions. During activation of such a system, water is assumed to penetrate a significant distance and without interrupti

Översiktliga beräkningar visar att ca 2 miljoner människor utsätts för trafikbullernivåer överstigande de riktvärden som riksdagen ställt sig bakom. Ungefär 500 000 av dessa utsätts för buller från tågtrafiken. Trafikbuller har betydelse för vår hälsa och de negativa effekterna kan vara störning av dagliga aktiviteter, stress sömnsvårigheter, koncentrationsproblem och högt blodtryck. Detta arbete Roughly 2 million Swedish citizens are exposed to traffic noise from roads, railways and aircrafts at levels higher than those approved by the government. As many as 500 000 of these are subject to railway noise. Exposure to traffic noise can have negative effects and cause irritation and disturbance of daily activities and also create general health problems such as lack of sleep, stress, concent

Oatly is a company that produces and sells oat based products. Their most selling product is the oat drink, which is a substitute to milk, and over 80 percent of the annual sales volume comes from this product. Since the foundation of Oatly, the main idea has been to sell their products on markets with low milk availability and milk consumption. Most recently, Oatly identified the Chinese market a

Populärvetenskaplig sammanfattning: Examensarbetet har gått ut på att med hjälp av satellitbilder göra markanvändningsdata för att förbättra en modell som beräknar vart de luftburna föroreningarna tar vägen. Föroreningarna svavel och kväve deponeras med olika hastighet över olika marktyper, därför vill man använda sig av markanvändningsdata i modellerna. Svavelutsläppen har ökat dramatiskt under Sulphur emissions during the last century has led to major acidification of the environment. The acidity of soil and water is a threat to health and economic interests of man, e.g. the food and paper/wood production in the agricultural and silvicultural industries. The Black Triangle region suffers from severe damage caused by acidification and actions to decrease the acid rain over fields and for

BACKGROUND: Acute myocardial infarct (AMI) size depicted by late gadolinium enhancement cardiovascular magnetic resonance (CMR) is increasingly used as an efficacy endpoint in randomized trials comparing AMI therapies. Infarct size is quantified using manual planimetry (MANUAL), visual scoring (VISUAL), or automated techniques using signal-intensity thresholding (AUTO). Although AUTO is considered

Background: Abdominal obesity is on the increase worldwide and ethnic minority groups are at high risk. However, studies of the underlying causes are scarce. The aims of this study were to investigate the prevalence of abdominal obesity and to identify metabolic, lifestyle and socio-demographic risk factors associated with abdominal obesity in male and female residents of Malmö, a city in southern

IMPORTANCE Timing of surgical aortic valve replacement (SAVR) in patients with aortic valve stenosis and previous stroke for the risk of recurrent stroke is insufficiently investigated. OBJECTIVE To evaluate the association of time elapsed between previous stroke and SAVR with the risk of recurrent perioperative stroke, major adverse cardiovascular events (MACE), and mortality among patients with

Cancer är den näst vanligaste dödsorsaken i världen idag och en tredjedel av Sveriges befolkning blir diagnosticerade med cancer under sin livstid. Av alla cancerfall i Sverige, så är prostatacancer den vanligaste och bröstcancer den näst vanligaste, medan hos enbart kvinnor så är bröstcancer den vanligaste med 29,2 % av cancerfallen. Överlevnaden efter en cancerdiagnos har i Sverige ökat sedan 70Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. Today, many assays use end-point analysis of large populations of cells, to evaluate the research question. However, there are many cases when

Background To benefit from the increasing clinical evidence, organisational changes have been among the main drivers behind the reduction of ICU mortality during the last decade. Increasing demand, costs and complexity, amplifies the need for optimisation of clinical processes and resource utilisation. Thus, multidisciplinary teamwork and critical care processes needs to be adapted to profit fro

Existing oculoplastic reconstructive surgical techniques are based on empirical knowledge and were established long before perfusion monitoring was possible. It is believed that an avascular graft should always be placed on a vascular bed or flap and also that the viable length of a flap depends on the width of its pedicle. The actual role of the length, width and thickness of a random flap in its