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Background: Gene expression (GEX) signatures in breast cancer provide prognostic information, but little is known about their predictive value for tamoxifen treatment. We examined the tamoxifen-predictive value and prognostic effects of different GEX signatures in premenopausal women with early breast cancer. Methods: RNA from formalin-fixed paraffin-embedded tumor tissue from premenopausal women
Background: Early detection of treatment response is important for the management of patients with malignant brain tumors such as glioblastoma to assure good quality of life in relation to therapeutic efficacy. Aim: To investigate whether parametric response mapping (PRM) with diffusion MRI may provide prognostic information at an early stage of standard therapy for glioblastoma. Materials and met
Ongoing consumption of fossil-based fuels generates a massive amount of greenhouse gases. This may lead to global warming that is currently threatening human society and wild animal habitats. Hydrogen is an energy carrier with the highest energy content per weight compared to other all fuels and no carbon dioxide is released when combusted. Thermophilic bacteria belonging to the genus of Caldicell
Background: Haematopoietic stem cells expressing the CD34 surface marker have been posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis infection. Our aim was to determine whether M tuberculosis complex DNA is detectable in CD34-positive peripheral blood mononuclear cells (PBMCs) isolated from asymptomatic adults living in a setting with a high tuberculosis
Epilepsy is one of the most common neurological disorders worldwide, affecting 1% of the general population, and is characterized by a predisposition for the generation of epileptic seizures. Despite having several different aetiologies, a common underlying cause of epilepsy seems to be an acquired imbalance between excitatory and inhibitory circuits in the brain, which leads to hyperexcitability
Context: The first therapeutic cancer vaccine demonstrating effectiveness in a phase 3 study was approved by the US Food and Drug Administration on 29 April 2010. The pivotal trial demonstrated overall survival (OS) benefit in patients treated with antigen-loaded leukapheresis cells compared with a control infusion. Results of other prostate cancer (PCa) vaccination strategies are awaited, as this
Ett grundläggande mål för EU är att skapa en inre marknad där fri rörlighet för varor, personer, tjänster och kapital skall säkerställas enligt artikel 2 EU och artikel 14 EG. Dessa fyra friheter kompletteras av bestämmelser om etableringsfrihet för såväl fysiska som juridiska personer i artiklarna 43 och 48 EG. Det finns även ett antal bolagsrättsliga direktiv, som syftar till att upphäva de hind
I denna framställning behandlas framförallt två problemområden med anknytning till överlåtelse av aktie. I den första delen utreds frågan om aktiesäljaren har en köp- eller avtalsrättslig skyldighet att upplysa köparen om sådana väsentliga förhållanden i bolaget som säljaren känner till och som är av avgörande betydelse för en korrekt värdering av aktierna. I den andra delen företas en undersöknin
Background: Animal studies suggest that the arginine vasopressin (AVP) system plays a role in glucose and fat metabolism, but data from humans are limited. Method and results: We analysed plasma copeptin (copeptin), a stable C-terminal fragment of the AVP pro-hormone in the large, Swedish, population-based cohort Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC, n=6103). Using baseline
As stated in Article 26 of ICCPR, ''all persons are equal before the law and are entitled without any discrimination to the equal protection of the law.'' The pursuit of equality and non-discrimination has been widely accepted not only as a formal principle but also binding substantive human rights. In 2003, the first Global Report by ILO on discrimination, Time for equality at wor
Abstract Toxic cyanobacterial blooms can form in both freshwater and marine environments, which could threaten the health of human beings and animals. The genera that are known for causing the scums in freshwater are Anabaena, Microcystis, Cylindrospermopsis and Planktothrix. In order to control lake water quality and minimize the potential health risk associated with the cyanobacterial blooms, th
In Sweden, the tramway was introduced in the late 19th century as horse tramways. Entrepreneurs around the country saw advantages of the new mean of transport which, due to low frictional resistance could transport a large amount of passengers with low traction force. In the beginning of the 20th century the horses were replaced by electric motors and the tramway spread to more cities. The entry o
Background & Problem: In previous years, there has been low focus on inventory control. Due to high margins on the products, a high inventory level has been kept to reduce the risk for lost sales. Today, the company is expanding, and therefore need to improve the inventory control to reduce tied-up capital. Purpose: The main purpose of this thesis is to reduce capital tied-up in inventories. B
Recent droughts from 2017 to 2020 induced significant stress on woodland canopies across eastern Australia, resulting in widespread tree browning and mortality. However, the trajectory of post-drought recovery remains unclear, with uncertainty about whether canopy conditions are improving or continuing to decline. Identifying the key local environmental and climatic factors influencing drought-ind
Importance: Alzheimer disease (AD) predominates in females at almost twice the rate relative to males. Mounting evidence in adults without AD indicates that females exhibit higher tau deposition than age-matched males, particularly in the setting of elevated β-amyloid (Aβ), but the evidence for sex differences in tau accumulation rates is inconclusive. Objective: To examine whether female sex is a
With the ongoing developments in the field of anti-amyloid therapy for Alzheimer’s disease, it is crucial to better understand the longitudinal associations between amyloid-β deposition and altered network activity in the living human brain. We included 110 cognitively unimpaired individuals (67.9 ± 5.7 years), who underwent [18F]flutemetamol (amyloid-β)-PET imaging and resting-state magnetoenceph
STUDY QUESTION: What is the risk of death among men with oligospermia, unspecified male factor and azoospermia in the years following fertility treatment? SUMMARY ANSWER: No significantly elevated risk was observed among men with oligospermia and unspecified male factor, while an increased risk was found among men with azoospermia. WHAT IS KNOWN ALREADY: Previous studies have shown associations be
Silk fibers offer untapped internal structures to template the formation of nano-objects and active coatings. So far, access to all or part of the internal and organized structures has been a significant challenge. The aim of the thesis is, therefore, to identify and exploit silk templating ability to create value-added multifunctional hybrid materials with enhanced conductive and catalytic proper
Computational approaches are essential to study the effects of inborn and somatic variations. Results from such studies contribute to better diagnosis and therapies. Primary immunodeficiencies (PIDs) are rare inborn defects of key immune response genes. Somatic variations are main drivers of most cancers. Large and diverse data on PID genes and proteins can enable systems biology studies on their
BACKGROUND: Osteopenia, osteoporosis, and low bone mineral density are frequent in patients with HIV. We assessed the 96 week loss of bone mineral density associated with a nucleoside or nucleotide reverse transcriptase inhibitor (NtRTI)-sparing regimen.METHODS: Antiretroviral-naive adults with HIV were enrolled in 78 clinical sites in 15 European countries into a randomised (1:1), open-label, non
