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In the presence of high concentrations of inert macromolecules, the self-association of proteins is strongly enhanced through an entropic, excluded-volume effect variously called macromolecular crowding or depletion attraction. Despite the predicted large magnitude of this universal effect and its far-reaching biological implications, few experimental studies of macromolecular crowding have been r

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An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Protein profiles of human cerebrospinal fluid samples from AD patients (n = 95) and population-based healthy controls (n = 72) were analyzed by SELDI-TO

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Time-resolved and spatially resolved measurements of the diffuse reflectance from biological tissue are two well-established techniques for extracting the reduced scattering and absorption coefficients. We have performed a comparison study of the performance of a spatially resolved and a time-resolved instrument at wavelengths 660 and 785 nm and also of an integrating-sphere setup at 550-800 nm. T

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Most structured latex particles are formed in the nonequilibrium state as a result of the reaction kinetics proceeding faster than the phase separation kinetics. Of the many factors controlling such morphologies, the polarity and glass transition temperature (Tg) of the seed polymer are important. In order to study the direct effect of the seed polymer Tg on morphology, we produced a series of pol

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We have performed a comparison of ten models that predict the temporal behavior of laser-induced incandescence (LII) of soot. In this paper we present a summary of the models and comparisons of calculated temperatures, diameters, signals, and energy-balance terms. The models were run assuming laser heating at 532 nm at fluences of 0.05 and 0.70 J/cm(2) with a laser temporal profile provided. Calcu

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Dynamic characterization of elastomers, i.e. laboratory testing and fitting of constitutive models, is quite complicated. The demands on the laboratory equipment and the skill of the personal handling the test equipment are high. Stationary harmonic testing is an established method for evaluating dynamic properties of elastomers. However, it is demanding experimentally when it comes to high freque

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Simultaneous OH- and formaldehyde planar-LIF measurements have been performed in an optical engine using two laser sources working on 283 and 355 nm, respectively. The engine used for the measurements was a car diesel engine converted to single-cylinder operation and modified for optical access. The fuel, n-heptane, was injected by a direct injection common-rail system and the engine was also fitt

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Popular Abstract in Swedish Gummi är inte enbart olinjärt elastiskt, det är också beroende av töjningshastighet och töjningsamplitud. Kombinationen av de olinjära elastiska egenskaperna och amplitudberoendet behandlas av de modeller som föreslås i avhandlingen. Modellerna är utformade så att de snabbt ska kunna implementeras i industrin.Rubber is not only a non-linear elastic material, it is also dependent on strain rate, temperature and strain amplitude. The non-linear elastic property and the strain amplitude dependence give a non-linear dynamic behavior that is covered by the models suggested in this thesis. The focus is on a finite element procedure for modelling these dynamic properties of rubber in a way that is easy to ado

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A section through the Upper Cambrian black shales and limestones at Kakeled on Kinnekulle, Vastergotland, Sweden, extends from the lower-middle part of the Agnostus pisiformis Zone into the Peltura scarabaeoides Zone. Fossils are usually preserved only in the stinkstones, but in the A. pisiformis Zone trilobites can be found also in the shales. Lithologically, the stinkstones can be subdivided int

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Dynamic mode I fracture initiation in impact loaded single edge bend specimens with a quarter notch is investigated by numerical modelling and the results are compared with sets of experimental data from two different steel qualities. The finite element analysis include 2D (two-dimensional) plane strain, 2D plane stress and 3D models. No crack growth is included in the calculations. The impact vel

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Popular Abstract in Swedish The last period of life among older people has been very little explored, even though it is well known that for the majority of the population death will occur in old age, both in Sweden and in other western countries. The intention in Swedish society is to provide high quality end of-life care for everyone (SOU 2001:6), not just to those receiving care in a hospital orThe aim of this thesis was to investigate old people's care and quality of life during the last period of life, but also to investigate their own and next-of-kin's experience of this phase. The thesis is based on four studies using separate samples. The sample (n=1198) in study I was drawn from the care and services part of the sub-study ?Good Aging in Skåne? (GAS). The criteria for inclusion in s

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This article is based on an analysis of Lund University that took place during the summer and autumn of 2004 (available for download at www.iiiee.lu.se, click library and publications). The university had experienced a loss of momentum in their progress regarding environmental issues. The purpose of the study was to identify barriers to including sustainability-related content throughout Lund Univ

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An efficient scheme for the simulation of quasi-static crack growth in two-dimensional linearly elastic isotropic specimens is presented. The crack growth is simulated in a stepwise manner where an extension to the already existing crack is added in each step. In a local coordinate system each such extension is represented as a polynomial of some, user specified, degree, n. The coefficients of the

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Modernitet och intermedialitet is the first major study of the Swedish modernist writer Erik Asklund (1908-1980) and his works. The thesis consists of an introductory chapter and three close readings of Asklund’s early novels Kvinnan är stor (The Woman is Great, 1931), Lilla land (A Small Country, 1933), and Fanfar med fem trumpeter (A Fanfare with Five Trumpets, 1934). In these novels, Asklund de

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The flow behavior in rib-roughened ducts is influenced by the inclination of ribs and the effect is investigated in the present study by Particle Image Velocimetry (PIV). The local flow structures between two adjacent ribs were measured. The Reynolds number was fixed at 5800. The flow field description was based on the PIV results in planes both parallel and perpendicular to the ribbed walls at va

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We analysed 57 years’ uninterrupted trapping data of autumn migrating Ruddy Turnstones Arenaria interpres at Ottenby, south-eastern Sweden (1593 full-grown birds in 1947–2003; of them 574 birds with standardised trapping in 1976–2003). Numbers trapped decreased significantly for both adult and juvenile birds in the total dataset (–0.34 and –0.57 ringed birds per year), and for juveniles in the 197