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Introduction: Emergency departments (ED) globally are addressing the coronavirus disease 2019 (COVID-19) pandemic with varying degrees of success. We leveraged the 17-country, Emergency Medicine Education & Research by Global Experts (EMERGE) network and non-EMERGE ED contacts to understand ED emergency preparedness and practices globally when combating the COVID-19 pandemic. Methods: We elect
AIMS: To characterize changes in patterns of adolescent substance use in Sweden between 1988 and 2011, and to assess whether sex and psychosomatic problems were associated with substance use and whether these associations changed over time.DESIGN: Secondary analysis of repeated cross-sectional survey data. Survey data were collected eight times and analyzed as four cohorts (1988-91, 1995-98, 2002-
We investigate whether number of episodes (NoEs) meaningfully reflect genetic risk and genetic heterogeneity for five primary disorders—Drug Use Disorder (DUD), Alcohol Use Disorder (AUD), Major Depression (MD), Bipolar Disorder (BD), and Schizophrenia (SZ) ascertained from Swedish population registries. We utilize Genetic Risk Ratios (GRR)—defined as the ratio of the genetic risk for secondary di
Purpose: To analyse graft detachment rates after Descemet stripping automated endothelial keratoplasty (DSAEK) using surgeon-cut grafts and pre-cut grafts transported in different mediums. Methods: A retrospective study of graft detachment rates including 265 surgeries (240 patients) performed between 2019 and 2023. The DSAEK grafts were either surgeon-cut (n = 135) or pre-cut and transported in a
The new evil demon problem amounts to a difficult challenge for the externalist about epistemic justification. Many solutions to the problem have been proffered in the almost 40 years since its first appearance in the literature. Among the more promising responses is indexical reliabilism, a combination of two versions of actual world reliabilism where “actual” denotes either the world of utteranc
Large increases in regional cerebral blood flow (rCBF) have been measured in patients with Parkinson's disease (PD) following the administration of L-DOPA, but the underlying mechanisms have remained unknown. In this study, we have used rats with unilateral 6-hydroxydopamine (6-OHDA) lesions as a model of PD in order to compare the patterns of rCBF and regional cerebral glucose utilisation (rCGU)
Objective: Most methods to detect copy number variation (CNV) have high false positive rates, especially for small CNVs and in real-life samples from clinical studies. In this study, we explored a novel scatterplot-based method to detect CNVs in microarray samples. Methods: Illumina SNP microarray data from 13,254 individuals were analyzed with scatterplots and by PennCNV. The data were analyzed w
This article analyzes the artistic exploration of machine vision in the video installation Modern Escape (2018) by Danish artist duo Hanne Nielsen and Birgit Johnsen. The artwork recreates a modern Western home pervaded by surveillance technologies and the automated vision of a robotic vacuum cleaner. The main conceptual idea of the work is the automated gaze, and with few exceptions, all the scen
During recent years the increasing power of computers and communications has led to the development and use of more advanced analysis techniques. Design of Experiment (DOE) has been used together with Finite Element (FE) analysis software such as ANSYS, see e.g. Johnson and Heald (1998) and Eriksson et al. (1998). Predictive Design Analysis (PDA) is an mechanical engineering design, or design for
Den nuvarande svenska arbetsrätten kan vara på kollisionskurs med EU-rätten avseende tidsbegränsade anställningar när det gäller implementeringen av direktiv 99/70/EG. EU-kommissionen anser att det finns en kollision mellan direktivet och sättet det införlivats i nationell rätt. Det finns bärkraftiga argument att samma skyddsnivå som avses i direktivet uppfylls indirekt genom de svenska arbetsrättCurrent Swedish labor rules may be on a collision with the European legal rules concerning time-limited employments arising from the EU directive 99/70/EC. The view of the European commission is that the directive has not been fulfilled and properly incorporated in the national rules. There are valid arguments that the level of protection as intended in the directive is achieved, regardless of the
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology.METHODS: We conducted a nested case-control study within the Syncope S
This paper examines the structural response of cold-formed steel-framed building lateral force-resisting systems under combinations of simulated earthquake and fire loading. Full-scale experiments with gypsum-sheet steel composite panel sheathed walls, oriented strand board sheathed walls, and steel strap braced walls are presented. Twenty-two test specimens are subjected sequentially to combinati
Identification of prostate gold fiducial markers in magnetic resonance imaging (MRI) images is challenging when CT images are not available, due to misclassifications from intra-prostatic calcifications. It is also a time consuming task and automated identification methods have been suggested as an improvement for both objectives. Multi-echo gradient echo (MEGRE) images have been utilized for manu
Background: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. Methods: In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly
This master thesis investigates the legal foundations for training of artificial intelligence (AI) models using personal data, with an emphasis on compliance with the European Union’s General Data Protection Regulation (GDPR). The core issue addressed is the lack of clear legal basis for AI training processes that involve the collection and use of personal data (gathered directly or indirectly thr
Introduction Systemic inflammation is postulated to mediate heat stroke and heat-related organ injury, yet acute inflammatory responses among heat-stressed workers remains poorly understood. We aimed to describe neutrophil mobilisation and potential release of DNA during heat stress in multiple hot occupational settings and a controlled experimental setting. Methods Neutrophil:lymphocyte ratio (NL
Populärvetenskaplig sammanfattning: En verksamhet eller åtgärd kan ha stor inverkan på människor, djur, växter, mark, vatten, luft, klimat, landskap och kulturmiljö. För att fatta bästa möjliga beslut om en projekt-ut-formning som tar hänsyn till konsekvenserna för olika berörda miljövärden åter-finns kravet på miljökonsekvensbeskrivning, MKB, i svensk lagstiftning. Syftet med en MKB är att identiAn activity or a measure might have a great impact on people, animals, plants, soil, water, air, climate and landscape. In order to describe the direct and indirect effects an intended activity might have an Environmental Impact Assessment (EIA) must be carried out. This demand is regulated in Swedish legislation and makes it possible to achieve as small impact on the environment as practicable. A
Since the Maastricht Treaty the European Parliament has gained competence in the decision-making process and the Parliament is today one of two decision-making institution, next to the Ministers of Council. In this study the main focus has been to shed light over the negotiation culture within the European Parliament, which up till now has been a neglected research area. This is of great significa
In the credit derivatives market, the observed default correlation smile, implied by the Gaussian copula, constitutes a major problem when we want to price bespoke CDO tranches. The industry standard approach for countering this dilemma is to use the concept of base correlation to try to estimate the ingoing default correlation parameters for non-standard tranche intervals. However, this approach
India's buildings sector accounts for 41% of national electricity consumption, yet studies incorporating calibrated whole-building energy simulation with thermal comfort evaluation of manufacturing facilities to reduce the industry’s electricity consumption remain scarce, leaving designers without evidence to prioritise passive strategies for this building typology. This study characterises th
